Suivi longitudinal des sujets contacts de cas de tuberculose à Paris

Fournier, A.; Antoun, F.; Ou, Ching-Haei; Müller, G.; Ezri, L.; Morin, P; Faure, A.; Marteau, Didier; Keshtmand, H.; Quélet, S.

doi:10.1016/j.rmr.2014.06.031

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Regular follow-up visits have been recommended for low-incidence countries, while often not being feasible in high-incidence countries [21]. With well-adherent treatment in the context of an infection with a drug-sensitive organism, the risk of progression to disease is low [37,46].…”

Section: Plos Onementioning

confidence: 99%

Management of childhood and adolescent latent tuberculous infection (LTBI) in Germany, Austria and Switzerland

et al. 2021

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Background Majority of active tuberculosis (TB) cases in children in low-incidence countries are due to rapid progression of infection (latent TB infection (LTBI)) to disease. We aimed to assess common practice for managing paediatric LTBI in Austria, Germany and Switzerland prior to the publication of the first joint national guideline for paediatric TB in 2017. Methods Online-based survey amongst pediatricians, practitioners and staff working in the public health sector between July and November 2017. Data analysis was conducted using IBM SPSS. Results A total of 191 individuals participated in the survey with 173 questionnaires included for final analysis. Twelve percent of respondents were from Austria, 60% from Germany and 28% from Switzerland. Proportion of children with LTBI and migrant background was estimated by the respondents to be >50% by 58%. Tuberculin skin test (TST) and interferon-γ-release-assay (IGRA), particularly Quantiferon-gold-test, were reported to be used in 86% and 88%, respectively. In children > 5 years with a positive TST or IGRA a chest x-ray was commonly reported to be performed (28%). Fifty-three percent reported to take a different diagnostic approach in children ≤ 5 years, mainly combining TST, IGRA and chest x-ray for initial testing (31%). Sixty-eight percent reported to prescribe isoniazid-monotherapy: for 9 (62%), or 6 months (6%), 31% reported to prescribe combination therapy of isoniazid and rifampicin. Dosing of isoniazid and rifampicin below current recommendations was reported by up to 22% of respondents. Blood-sampling before/during LTBI treatment was reported in >90% of respondents, performing a chest-X-ray at the end of treatment by 51%. Conclusion This survey showed reported heterogeneity in the management of paediatric LTBI. Thus, regular and easily accessible educational activities and national up-to-date guidelines are key to ensure awareness and quality of care for children and adolescents with LTBI in low-incidence countries.

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Section: Plos Onementioning

confidence: 99%

Management of childhood and adolescent latent tuberculous infection (LTBI) in Germany, Austria and Switzerland

et al. 2021

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S2k-Leitlinie zur Diagnostik, Prävention und Therapie der Tuberkulose im Kindes- und Jugendalter

Feiterna‐Sperling

Brinkmann

Adamczick³

et al. 2017

Pneumologie

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Recently, epidemiological data shows an increase of childhood tuberculosis in Germany. In addition to this, drug resistant tuberculosis becomes more frequent. Therefore, diagnosis, prevention and therapy in childhood and adolescence remain a challenge. Adult guidelines do not work for children, as there are age specific differences in manifestation, risk of progression and diagnostic as well as therapeutic pathways.The German Society for Pediatric Infectious Diseases (DGPI) has initiated a consensus-based (S2k) process and completed a paediatric guideline in order to improve and standardize care for children and adolescents with tuberculosis exposure, infection or disease.Updated dosage recommendations take age dependant pharmacokinetics in the treatment of drug sensitive but also drug resistant tuberculosis in account. In addition to this, there is a detailed chapter on perinatal exposure and disease as well as extrapulmonary manifestations.

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Neither genotyping nor contact tracing allow correct understanding of multidrug-resistant tuberculosis transmission

Fournier¹,

Bernard²,

Sougakoff³

et al. 2017

Eur Respir J

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The control of tuberculosis (TB) is challenged by the progressive increase of cases of multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). A recent European study underlined the need for data showing how TB control can be improved in terms of case finding, contact tracing, infection control and treatment to prevent further spread of MDR-/XDR-TB in the EU [1]. In France, the number of MDR-TB cases has markedly increased in recent years [2]. This increase represents a challenge for the control of MDR-TB in the city of Paris, in which one-third of all national MDR-TB cases are concentrated [3]. We performed a study to investigate if this increase of MDR-TB index cases is accompanied by increased transmission. The study was conducted between January 1, 2010 and September 30, 2013, and was a prospective collaborative study between the Centre de Lutte Anti-tuberculeuse de Paris (CLAT75) and the Centre National de Référence des Mycobactéries (NRC).

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Suivi longitudinal des sujets contacts de cas de tuberculose à Paris

Cited by 3 publications

References 13 publications

Management of childhood and adolescent latent tuberculous infection (LTBI) in Germany, Austria and Switzerland

Management of childhood and adolescent latent tuberculous infection (LTBI) in Germany, Austria and Switzerland

S2k-Leitlinie zur Diagnostik, Prävention und Therapie der Tuberkulose im Kindes- und Jugendalter

Neither genotyping nor contact tracing allow correct understanding of multidrug-resistant tuberculosis transmission

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