Suitable reference tissues for quantitative susceptibility mapping of the brain

Straub, Sina; Schneider, Till; Emmerich, Julian; Freitag, Martin T.; Ziener, Christian H.; Schlemmer, Heinz Peter; Ladd, Mark E.; Laun, Frederik Bernd

doi:10.1002/mrm.26369

Cited by 87 publications

(94 citation statements)

References 42 publications

(60 reference statements)

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“…We abided by the following principles when drawing the ROIs to avoid containing adjacent brain regions from separate ROIs: (1) draw all successive slices with a clear, visible boundary of the nucleus in the axial plane; (2) remove the first and last layers of the nucleus; (3) draw a pixel point inward to ensure that the region drawn is within the scope of the nucleus; and (4) avoid obvious vascular structures. The QSM values (referenced to the susceptibility in the bilateral posterior limb of the internal capsule, http://www.brainlabel.org) were calculated. Mean QSM values within each ROI in each group are shown in Table .…”

Section: Methodsmentioning

confidence: 99%

Quantitative Evaluation of Iron Content in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Sun

Lai

et al. 2019

Movement Disorders

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Background Idiopathic rapid eye movement sleep behavior disorder is an early sign of neurodegenerative disease. This study aimed to quantitatively evaluate iron content in idiopathic rapid eye movement sleep behavior disorder patients using quantitative susceptibility mapping and to examine the potential of this technique to identify the prodromal stage of α‐synucleinopathies. Methods Twenty‐five idiopathic rapid eye movement sleep behavior disorder patients, 32 Parkinson's disease patients, and 50 healthy controls underwent quantitative susceptibility mapping. The mean magnetic susceptibility values within the bilateral substantia nigra, globus pallidus, red nucleus, head of the caudate nucleus, and putamen were calculated and compared among groups. The relationships between the values and the clinical features of idiopathic rapid eye movement sleep behavior disorder and Parkinson's disease were measured using correlation analysis. Results Idiopathic rapid eye movement sleep behavior disorder patients had elevated iron in the bilateral substantia nigra compared with healthy controls. Parkinson's disease patients had increased iron in the bilateral substantia nigra, globus pallidus, and left red nucleus compared with healthy controls and had elevated iron levels in the bilateral substantia nigra compared with idiopathic rapid eye movement sleep behavior disorder patients. Mean magnetic susceptibility values were positively correlated with disease duration in the left substantia nigra in idiopathic rapid eye movement sleep behavior disorder patients. Conclusions Quantitative susceptibility mapping can detect increased iron in the substantia nigra in idiopathic rapid eye movement sleep behavior disorder, which becomes more significant as the disorder progresses. This technique has the potential to be an early objective neuroimaging marker for detecting α‐synucleinopathies. © 2019 International Parkinson and Movement Disorder Society

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Section: Methodsmentioning

confidence: 99%

Quantitative Evaluation of Iron Content in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Sun

Lai

et al. 2019

Movement Disorders

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“…NAWM masks were generated by subtracting the lesion masks from the supratentorial cerebral hemispheric white matter masks. In order to compare tissue QS between individuals, the CSF QS within the lateral ventricular atrium was selected as an internal reference [26]. …”

Section: Methodsmentioning

confidence: 99%

Characterization of normal-appearing white matter in multiple sclerosis using quantitative susceptibility mapping in conjunction with diffusion tensor imaging

Chiang

Stephens

et al. 2018

Neuroradiology

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Purpose Quantitative susceptibility mapping (QSM) is influenced by iron as well as myelin, which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR sequences that are sensitive to axonal/myelin integrity, such as diffusion tensor imaging (DTI), may provide context for interpreting quantitative susceptibility (QS) signal. The purpose of our study was to investigate alterations in normal-appearing white matter (NAWM) in multiple sclerosis (MS) using QSM in conjunction with DTI. Methods Twenty relapsing–remitting MS patients and 20 age-matched healthy controls (HC) were recruited for this prospective study. QS, radial diffusivity (RD), fractional anisotropy (FA), and R2* maps within the whole brain as well as individual tracts were generated for comparison between NAWM and HC white matter (HCWM). Results MS lesions demonstrated significant differences in QS, FA, RD, and R2* compared to HCWM (p < 0.03). These metrics did not show a significant difference between whole-brain NAWM and HCWM. Among NAWM tracts, the cingulate gyri demonstrated significantly decreased QS compared to HCWM (p = 0.004). The forceps major showed significant differences in FA and RD without corresponding changes in QS (p < 0.01). Conclusion We found discordant changes in QSM and DTI metrics within the cingulate gyri and forceps major. This may potentially reflect the influence of paramagnetic substrates such as iron, which could be decreased along these NAWM tracts. Our results point to the potential role of QSM as a unique biomarker, although additional validation studies are needed.

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“…In the (human) brain, variability has been shown in a number of regions commonly used as references in QSM studies. CSF has been shown to have the smallest variability (mean susceptibility 10 ± 14 ppb), whereas in the same study the mean susceptibility of the white matter ranged from 6 ± 20 ppb to 28 ± 23 ppb depending on the location in which it was measured . Furthermore, it has been shown that the susceptibility of CSF can change under the administration of gases .…”

Section: Discussionmentioning

confidence: 81%

Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI

Finnerty

Ramasawmy

O’Callaghan

et al. 2018

Magnetic Resonance in Med

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Purpose This preclinical study investigated the use of QSM MRI to noninvasively measure venous oxygen saturation (SvO2) in the hepatic and portal veins. Methods QSM data were acquired from a cohort of healthy mice (n = 10) on a 9.4 Tesla MRI scanner under normoxic and hyperoxic conditions. Susceptibility was measured in the portal and hepatic veins and used to calculate SvO2 in each vessel under each condition. Blood was extracted from the inferior vena cava of 3 of the mice under each condition, and SvO2 was measured with a blood gas analyzer for comparison. QSM data were also acquired from a cohort of mice bearing liver tumors under normoxic conditions. Susceptibility was measured, and SvO2 calculated in the portal and hepatic veins and compared to the healthy mice. Statistical significance was assessed using a Wilcoxon matched‐pairs signed rank test (normoxic vs. hyperoxic) or a Mann‐Whitney test (healthy vs. tumor bearing). Results SvO2 calculated from QSM measurements in healthy mice under hyperoxia showed significant increases of 15% in the portal vein ( P < 0.05) and 21% in the hepatic vein ( P < 0.01) versus normoxia. These values agreed with inferior vena cava measurements from the blood gas analyzer (26% increase). SvO2 in the hepatic vein was significantly lower in the colorectal liver metastases cohort (30% ± 11%) than the healthy mice (53% ± 17%) ( P < 0.05); differences in the portal vein were not significant. Conclusion QSM is a feasible tool for noninvasively measuring SvO2 in the liver and can detect differences due to increased oxygen consumption in livers bearing colorectal metastases.

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Suitable reference tissues for quantitative susceptibility mapping of the brain

Cited by 87 publications

References 42 publications

Quantitative Evaluation of Iron Content in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Quantitative Evaluation of Iron Content in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Characterization of normal-appearing white matter in multiple sclerosis using quantitative susceptibility mapping in conjunction with diffusion tensor imaging

Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI

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