Suitable bone markers assessing bone status in patients with both coronary artery disease and diabetes

Maghbooli, Zhila; Emamgholipour, Solaleh; Hossein–Nezhad, Arash; Shirzad, Mahmood; Gorgani‐Firuzjaee, Sattar

doi:10.1186/s40200-016-0259-1

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…To the best of our knowledge, this is the first study measuring bone turnover markers in premenopausal women with T2DM. Our findings are in agreement with previous studies which reported lower bone resorption [ 30 – 38 ] and bone formation [ 35 , 39 ] in T2DM individuals.…”

Section: Discussionsupporting

confidence: 94%

Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study

et al. 2017

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BackgroundIndividuals with Diabetes Mellitus (DM) are at increased risk for fracture due to the decrease in bone strength and quality. Serum procollagen type I intact N-terminal (P1NP) and serum C-terminal cross-linking telopeptide of type I collagen (CTX) as markers of bone formation and resorption, respectively, have been reported to be decreased in T2DM. It remains unclear whether diabetes-associated alterations in the bone turnover of T2DM individuals are related to the longer duration of the disease or may occur earlier. Furthermore, previous studies on BTMs in T2DM individuals have mostly been done in postmenopausal women with T2DM, which might have masked the DM-induced alterations of bone turnover with concurrent estrogen deficiency. This study aims to assess the levels of serum P1NP and CTX as markers of bone turnover in premenopausal women with and without T2DM.MethodsThis cross-sectional study involves 41 premenopausal women with T2DM, and 40 premenopausal women without DM. Sampling was done consecutively. P1NP and CTX measurement was done using the electrochemi-luminescence immunoassay (ECLIA) method. Other data collected include levels of HbA1C, ALT, creatinine, eGFR and lipid profile.ResultsMedian (interquartile range) P1NP in T2DM is 29.9 ng/ml (24.7–41.8 ng/ml), while in non-DM is 37.3 ng/ml, (30.8–47.3 ng/ml; p = 0.007). Median (interquartile range) CTX in T2DM is 0.161 ng/ml (0.106–0.227 ng/ml), while in non-DM is 0.202 ng/ml (0.166–0.271 ng/ml; p = 0.0035). Levels of P1NP and CTX in the T2DM group did not correlate with the duration of disease, age, BMI or the levels of HbA1C.ConclusionsPremenopausal women with T2DM indeed have lower bone turnover when compared with non-DM controls. This significantly lower bone turnover process starts relatively early in the premenopausal age, independent of the duration of DM. Gaining understanding of the early pathophysiology of altered bone turnover may be key in developing preventive strategies for diabetoporosis.

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Section: Discussionsupporting

confidence: 94%

Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study

et al. 2017

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“…[16] Elevating of Thai aging population is a trend to increase with the number of osteoporosis in elderly [17] and will be fast increase along with common chronic diseases, such as diabetes mellitus and cardiovascular diseases. [18,19] From Thai nation-wide survey (during 2000-2001), the age-adjusted prevalence of osteoporosis in Thai women ranging in age from 40 to 80 years was 13.6% and 19.8% for femoral neck and lumbar spine, respectively. For men, the age-adjusted prevalence of osteoporosis was 12.6, 4.6, and 3.9% at the femoral neck, lumbar spine, and both sites, respectively.…”

Section: Original Articlementioning

confidence: 99%

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Sudjaroen¹

2018

AJP

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Context: The association of bone turnover markers (BTMs) and cardiovascular disease had been representing. Aims: The study aimed to evaluate the association of osteoporosis status and prehypertension in elders, who were indicated by bone related -and cardiovascular risked -biochemical markers. Settings and Design: A cross-sectional study was carried out in Samut Songkhram, Thailand, and 105 elders were joined. , calcium, phosphorus, and magnesium); lipid profile (cholesterol, triglyceride, high density lipoprotein-cholesterol, and low density lipoprotein); and high sensitive C-reactive protein (hs-CRP) were analyzed using automatic analyzers. Blood pressure measurement was done after resting. Statistical Analysis Used: Descriptive data were represented as a mean ± standard deviation. One-way ANOVA was compared parameters within three elders groups. Pearson's correlation was tested for the relations of BMD with other parameters. Odds ratio was calculated for risk of prehypertension. Results: BMD was significantly correlated to calcium, phosphorus, and triglyceride in high, low, and very low levels, respectively. Inversely correlations of BMD with CTX and hs-CRP were significant in medium level. Risk of prehypertension was increased 1.12-fold with a decrement of T-score < −1.0. Increment of CTX, hs-CRP, and LDL-C was increased 1.93, 1.94, and 1.31-fold of prehypertension risks, respectively. Conclusions: Prehypertension was associated with osteoporosis, which indicated by inversely correlation of hs-CRP and CTX to BMD; and correlation of serum calcium, phosphorus, and triglyceride to BMD.

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“…[5] In Thailand, the increment of life period is a trend to increase the number of elders and the rate of osteoporosis will be rapidly increased [6] along with common chronic diseases, such as diabetic mellitus and cardiovascular diseases. [7][8][9]…”

Section: Introductionmentioning

confidence: 99%

Untitled

Sudjaroen¹

2018

AJP

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Context: Calcaneal quantitative ultrasound (QUS) is attractive as a pre-screening tool for osteoporosis, alternative to dual-energy X-ray absorptiometry. Bone turnover markers (BTMs) are represented as bone formation indicators. QUS and BTM analysis may provide osteoporosis screening and bone turnover status, which provide benefit for osteoporosis management. Aims: The aims of this study were (1) to compare the values of bone mineral density (BMD) and BTMs, including N-terminal extension propeptide of type-I collagen, alkaline phosphatase (ALP), C-terminal telopeptide of type-I collagen (CTX), and osteocalcin (OC), and bonerelating biochemical parameters, such as 25-hydroxyvitamin D (25(OH)D), calcium, phosphorus and magnesium between osteoporotic, osteopenia, and normal BMD elders and (2) to investigate the relationship between serum BTMs and BMD. Materials and Methods: Determination of BMD, BTMs, and bone-related biochemical parameters from 150 of the elders at Amphawa District, Sumut Songkhram, was determined by calcaneal QUS and automatic analyzers, respectively. One-way ANOVA was used to compare continuous variables between three elder groups. Multiple comparisons among groups were used least-significance different. Pearson correlation was used to evaluate the correlation between BMD and BTMs. The statistical significance was considered at P < 0.05. Results and Discussion: BMD, calcium, phosphorus, and CTX levels were significantly different among three elder groups. CTX was significantly inversely correlated to BMD. Calcium, phosphorus, and CTX can be useful with osteoporosis screening by QUS, especially for osteopenia. Conclusions: Combination of calcaneal QUS and biochemical tests, including serum calcium, phosphorus, and CTX measurement as early diagnosis, provides more benefits for osteoporosis management and suitable for mass screening and intervention.

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Suitable bone markers assessing bone status in patients with both coronary artery disease and diabetes

Cited by 4 publications

References 30 publications

Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study

Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study

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