Suitability of Vigilance Test Data as a Neurobehavioral Measure of Uremic Status

Abstract

A vigilance/continuous performance test was designed to be used for the serial testing of patients on chronic maintenance hemodialysis therapy. Correct detections, false alarms, and reaction time provided measures of an attentional deficit. A matched sample of 28 patients and 28 controls composed of nondialysands were tested. No significant differences were found between groups in correct detections and false alarms. Reaction time discriminated younger and older subjects and also dialysands and controls. The clinical usage of the test is questioned because patients resist taking the test on a serial basis every 2 wk. Motivational factors or lack of willingness to be compliant outweighed technical accomplishments.

Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis

“…One neuropsychological study documented that partial metabolites and excessive toxins could be removed when undergoing dialysis to retain effective basic life support [5]. Although some researchers pointed out that ESRD patients who are undergoing dialysis have universally been discovered to perform better than non-dialysis patients with ESRD on neuropsychological tests [6][7][8][9][10][11][12], others observed the persistence of cognitive dysfunction in ESRD patients on dialysis [6,7,9,[11][12][13][14][15][16][17][18][19][20][21][22][23]. Hence, it is necessary to explore the effect of dialysis on the pathophysiology of cognitive dysfunction in patients with ESRD.…”

Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis

“…One neuropsychological study documented that the partial metabolites and excessive toxins could be removed undergoing dialysis to retain effective basic life support [5]. Although some researchers pointed out that ESRD patients who are undergoing dialysis have universally been discovered to perform better than non-dialysis patients with ESRD on neuropsychological tests [6][7][8][9][10][11][12], others observed the persistence of cognitive dysfunction in ESRD patients on dialysis [6,7,9,[11][12][13][14][15][16][17][18][19][20][21][22][23]. Hence, it is necessary to explore the effect of dialysis on the pathophysiology of cognitive dysfunction in patients with ESRD.…”