Suitability of POC lactate methods for fetal and perinatal lactate testing: considerations for accuracy, specificity and decision making criteria

Orsonneau, Jean-Luc; Fraissinet, François; Sebille, Véronique; Dudouet, D; Bigot‐Corbel, Edith

doi:10.1515/cclm-2012-0201

Cited by 18 publications

(9 citation statements)

References 15 publications

(11 reference statements)

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“…The correlation and categorization of BLAC from both testing methods show that POCT can accurately measure blood lactic acid values in cancer patients. This finding is consistent with those from previous studies that have shown that a POC device can provide reliable blood lactic acid measurements in ED and delivery rooms [8][9][10]. The assessment of lactic acid by POCT in cancer patients can timely identify who is at risk for sepsis.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies have shown that POC devices are able provide reliable measurements of lactate levels in delivery rooms and emergency departments (ED) [8][9][10]. In the study reported here, we shift the focus to cancer patients who not only have cells producing more lactate but may be receiving treatment making them more susceptible to systemic infections.…”

Section: Introductionmentioning

confidence: 98%

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Value Added Impact of Both Point-of-Care and Laboratory Lactic Acid Analysis When Emergently Evaluating Cancer Patients

et al. 2020

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Introduction: Cancer patients are immunosuppressed and may present to an emergency department with atypical symptoms. In the emergency setting, it is important ascertain rapidly if lactic acid levels are high, either due to sepsis or tumor lysis syndrome, to effectively manage symptoms. Therefore, it is critical to determine the blood lactic acid level to timely identify who is at risk of sepsis and provide early intervention. We have compared blood lactic acid concentrations (BLAC) in cancer patients obtained by point-of-care testing (POCT) and those measured by laboratory analysis in blood samples drawn within a short time of each other. Methods: This was a retrospective study in cancer patients whose BLAC had been

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Value Added Impact of Both Point-of-Care and Laboratory Lactic Acid Analysis When Emergently Evaluating Cancer Patients

et al. 2020

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“…Frequently evaluated lactate POCT devices are strip-analyzers, like the Lactate-Pro (Arkray) and StatStrip Lactate (Nova Biomedical), which have been shown to have satisfactory analytical performance. The StatStrip Lactate was found to perform the best, based on interference studies and imprecision (coefficient of variation, CV) measurements [11] , [12] . Recently, these conclusions were confirmed in a large study population resulting in a strong reduction in failure rates, compared with fetal scalp blood sampling, mainly caused by a shortage of sample resulting in no measurement on blood gas analyzers [6] .…”

Section: Introductionmentioning

confidence: 99%

Lactate point-of-care testing for acidosis: Cross-comparison of two devices with routine laboratory results

Horssen

Schuurman

Groot

et al. 2016

Practical Laboratory Medicine

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ObjectivesLactate is a major parameter in medical decision making. During labor, it is an indicator for fetal acidosis and immediate intervention. In the Emergency Department (ED), rapid analysis of lactate/blood gas is crucial for optimal patient care. Our objectives were to cross-compare-for the first time-two point-of-care testing (POCT) lactate devices with routine laboratory results using novel tight precision targets and evaluate different lactate cut-off concentrations to predict metabolic acidosis.Design and methodsBlood samples from the delivery room (n=66) and from the ED (n=85) were analyzed on two POCT devices, the StatStrip-Lactate (Nova Biomedical) and the iSTAT-1 (CG4+ cassettes, Abbott), and compared to the routine laboratory analyzer (ABL-735, Radiometer). Lactate concentrations were cross-compared between these analyzers.ResultsThe StatStrip correlated well with the ABL-735 (R=0.9737) and with the iSTAT-1 (R=0.9774) for lactate in umbilical cord blood. Lactate concentrations in ED samples measured on the iSTAT-1 and ABL-735 showed a correlation coefficient of R=0.9953. Analytical imprecision was excellent for lactate and pH, while for pO2 and pCO2 the coefficient of variation was relatively high using the iSTAT-1.ConclusionBoth POCT devices showed adequate analytical performance to measure lactate. The StatStrip can indicate metabolic acidosis in 1 μl blood and will be implemented at the delivery room.

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“…Previous studies [23][24][25][26] have shown promising results. However, some of the previous studies were undertaken in circumstances that did not adequately represent real labor ward conditions for analyzing fetal scalp blood samples.…”

Section: Discussionmentioning

confidence: 98%

Validation of a point-of-care (POC) lactate testing device for fetal scalp blood sampling during labor: clinical considerations, practicalities and realities

Reif

Lakovschek

Tappauf

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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A POC device which allows for a calibration adjustment to be made following preclinical testing can provide results that will correlate closely to an incumbent lactate method such as a blood gas analyzer. The use of a POC lactate device can address the impracticality and reality of pH sample collection and testing failures experienced in day to day clinical practice. For the StatStrip Lactate meter we suggest using a lactate cut-off of 5.1 mmol/L for predicting fetal acidosis (pH<7.20).

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Suitability of POC lactate methods for fetal and perinatal lactate testing: considerations for accuracy, specificity and decision making criteria

Cited by 18 publications

References 15 publications

Value Added Impact of Both Point-of-Care and Laboratory Lactic Acid Analysis When Emergently Evaluating Cancer Patients

Value Added Impact of Both Point-of-Care and Laboratory Lactic Acid Analysis When Emergently Evaluating Cancer Patients

Lactate point-of-care testing for acidosis: Cross-comparison of two devices with routine laboratory results

Validation of a point-of-care (POC) lactate testing device for fetal scalp blood sampling during labor: clinical considerations, practicalities and realities

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