Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

Cymbaluk‐Płoska, Aneta; Chudecka‐Głaz, Anita; Pius-Sadowska, Ewa; Machaliński, Bogusław; Menkiszak, Janusz; Sompolska-Rzechuła, Agnieszka

doi:10.1186/s13048-017-0373-9

Cited by 38 publications

(36 citation statements)

References 22 publications

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“…Significantly higher mean levels of serum MMP3 were noticed in patients with higher clinical staging compared to patients diagnosed with a lower staging. Moreover, the study demonstrated that baseline MMP3 concentrations were associated with patient survival and disease-free time [156].…”

Section: Ovarian Cancermentioning

confidence: 87%

The Role of Zinc and Copper in Gynecological Malignancies

Michalczyk

Cymbaluk‐Płoska

2020

Nutrients

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Zinc (Zn) and copper (Cu) are essential microelements, which take part in cellular metabolism, feature in enzymatic systems, and regulate enzyme activity. Homeostasis of these micronutrients is tightly regulated by multiple compensatory mechanisms that balance their concentrations including transporters, importers, and metallothioneins. An altered intake of only one of these trace elements may cause an imbalance in their levels and result in their competition for absorption. Relatively low levels of zinc and increased levels of copper may result in an increased level of oxidative stress and impair the antioxidant properties of multiple enzymes. Altered levels of trace elements were discovered in various pathologies including immunological, degenerative, and inflammatory diseases. Moreover, due to the role of Zn and Cu in oxidative stress and chronic inflammation, they were found to influence cancerogenesis. We review the roles of zinc and copper and their mechanisms in tumor growth, metastasis potential, microenvironment remodeling, and drug resistance. We highlight their role as potential biomarkers for cancer diagnosis, treatment, and prognosis, concentrating on their impact on gynecological malignancies.

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Section: Ovarian Cancermentioning

confidence: 87%

The Role of Zinc and Copper in Gynecological Malignancies

Michalczyk

Cymbaluk‐Płoska

2020

Nutrients

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“…Circulating protein levels of MMP3 have been reported to be increased in oral squamous cell carcinoma (OSCC), gastric cancer and prostate carcinoma 15 . Moreover, serum MMP3 concentrations have been investigated to meet the criteria of a good diagnostic test for ovarian cancer 16 . Recently, high levels of serum MMP3 concentrations were reported in NPC, which is consistent with our results 10 .…”

Section: Discussionmentioning

confidence: 99%

Combination of serum matrix metalloproteinase-3 activity and EBV antibodies improves the diagnostic performance of nasopharyngeal carcinoma

Feng

Xing

et al. 2020

J. Cancer

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Objective: Nasopharyngeal carcinoma (NPC) is a malignant head and neck tumor that is highly prevalent in Southeast Asia. The two traditional NPC markers VCA-IgA (EBV viral capsid antigen) and EA-IgA (EBV early antigen) are limited in the screening and diagnosis of NPC. The purpose of present study is to evaluate the diagnostic value of matrix metalloproteinase-3 (MMP3) in NPC. Methods: The levels of 23 secretory MMPs in serum samples from 15 healthy controls and 26 NPC patients were detected by Cytokine Antibody Array 2000. Immunohistochemistry, Real-time PCR and western bolt were used to detect MMP3 mRNA and protein levels in NPC tissues and cell lines. The serum protein levels of MMP3 were further measured by ELISA in healthy control individuals (n = 200) and NPC patients (n = 206). Results: MMP3 can be expressed and secreted by both NPC and fibroblast cell lines, suggesting that the higher expression of MMP3 protein in both tumor nests and stromal of NPC tissues may be the source of circulating MMP3 in NPC patients. Furthermore, we found out both MMP3 concentration and enzymatic activity were significantly increased in the NPC group (n = 206) than the healthy control group (n = 200) (P < 0.001). However, serum MMP3 enzymatic activity, but not MMP3 concentration, was significantly associated with the progression of NPC. In addition, serum MMP3 activity was more valuable in diagnosis of NPC than its concentration (0.86 vs. 0.78, AUC), and MMP3 activity can improve the diagnosis of NPC by combining with EBV-infection biomarkers VCA-IgA and EA-IgA with a sensitivity of 91.5% and a specificity of 92.3%. Conclusions: This study suggested the combination of MMP3 activity and EBV antibodies may be a useful biomarker for screening and diagnosis of NPC.

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“…These exosomal miRNAs exhibited a similar expression profile in tumor tissue and were not detected in the sera of healthy controls. Recently, Kobayashi et al [ 128 ] used microarrays to profile miRNAs in exosomes isolated from the conditioned media of HGSC cell lines and immortalized ovarian surface epithelial cells. A single upregulated miRNA was selected for subsequent quantification in EOC patient sera and was found to be differentially expressed between sera of HGSC patients and sera from non-HGSC patients [ 128 ].…”

Section: Emerging High-throughput Biomarker Discovery Approachesmentioning

confidence: 99%

High-throughput approaches for precision medicine in high-grade serous ovarian cancer

et al. 2020

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High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-fits-all clinical management approach. However, the majority of HGSC patients still relapse with chemo-resistant cancer and eventually succumb to their disease, evidence that further work is needed to improve patient outcomes. Advancements in high-throughput technologies have enabled novel insights into biological complexity, offering a large potential for informing precision medicine efforts. Here, we review the current landscape of clinical management for HGSC and highlight applications of high-throughput biological approaches for molecular subtyping and the discovery of putative blood-based biomarkers and novel therapeutic targets. Additionally, we present recent improvements in model systems and discuss how their intersection with high-throughput platforms and technological advancements is positioned to accelerate the realization of precision medicine in HGSC.

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Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

Cited by 38 publications

References 22 publications

The Role of Zinc and Copper in Gynecological Malignancies

The Role of Zinc and Copper in Gynecological Malignancies

Combination of serum matrix metalloproteinase-3 activity and EBV antibodies improves the diagnostic performance of nasopharyngeal carcinoma

High-throughput approaches for precision medicine in high-grade serous ovarian cancer

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