Suicide risk in depression and bipolar disorder: Do impulsiveness-aggressiveness and pharmacotherapy predict suicidal intent?

Pompili, Maurizio; Innamorati, Marco; Raja, Michele; Falcone, Ilaria; Ducci, Giuseppe; Angeletti, Gloria; Lester, David; Girardi, Paolo; Tatarelli, Roberto; Pisa, Eleonora De

doi:10.2147/ndt.s2192

Cited by 84 publications

(45 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our sample size has adequate power; thus, we conclude that prior psychiatric family history is not strongly associated with suicide attempt status in mood disorder patients, but family history of suicide is. We should also note that in our sample the percentage of suicide attempters in the MDD and BD groups did not differ significantly, which is contrary to prior observations that show higher suicide attempter rates in BD patients [109,110]; however, no differences between the two groups have also been found [111].…”

Section: Discussioncontrasting

confidence: 99%

Clinical and genetic factors associated with suicide in mood disorder patients

Antypa¹,

Souery²,

Tomasini³

et al. 2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

stronger predictor of current suicide risk. No associations were found with polymorphisms within COMT and BDNF genes, whereas significant associations were found with variations in rs13515 (MAPK1) and rs6740584 (CREB1) polymorphisms. From a clinical perspective, our study proposes several clinical characteristics, such as increased depressive symptomatology, anxiety comorbidity, functional disability and family history of suicidality, as correlates associated with suicide. Genetic risk variants in MAPK1 and CREB1 genes might be involved in a dysregulation of inflammatory and neuroplasticity pathways and are worthy of future investigation.

show abstract

Section: Discussioncontrasting

confidence: 99%

Clinical and genetic factors associated with suicide in mood disorder patients

Antypa¹,

Souery²,

Tomasini³

et al. 2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Yet, a single risk factor is not sufficient to predict suicide. As Pompili et al (46) wrote: "Despite intensive efforts, effective prediction and prevention strategies have remained elusive". To date, there have been no studies examining the relation between empathic responding and suicidality in patients with MDD.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the BHS seems to be a useful predictor of eventual suicidal behavior. The present study used a cutoff score of ≥9 to identify patients at high risk for suicide as previously done in a study conducted by Pompili et al (46). It is a valid and reliable instrument for Turkish healthy and psychiatric populations (28,29).…”

Section: Beck Hopelessness Scale (Bhs)mentioning

confidence: 99%

Relationship between empathic responding and its clinical characteristics in patients with major depressive disorder

Ekinci¹,

Ekinci²

2016

Dusunen Adam

View full text Add to dashboard Cite

Relationship between empathic responding and its clinical characteristics in patients with major depressive disorder Objective: To our knowledge, there is no study specifically examining the relation between empathic responding and clinical features in patients with major depressive disorder (MDD). Our aim was to examine cognitive and affective empathic responding in patients with MDD and to explore the possible relations between clinical features and empathy. Method:The sociodemographic and clinical properties of 83 patients with major depression were recorded. The Beck Depression Inventory (BDI) was used to assess severity of depression, whereas the Beck Anxiety Inventory (BAI) was used to assess anxiety. Hopelessness level was measured by Beck Hopelessness Scale (BHS). Patients' empathic ability was evaluated by using the Interpersonel Reactivity Index (IRI), and results were compared with 85 healthy controls. We used Pearson correlation and general linear model analysis to evaluate the manner in which the variables contributed to the IRI scores.Results: Perspective Taking (IRI-PT), Empathic Concern (IRI-EC), and Fantasy (IRI-FS) subscores were all substantially lower in subjects with depression than in healthy controls, while the Personal Distress (IRI-PD) subscore was higher than in healthy subjects. There were significant effects of gender on the scores of IRI-EC and IRI-FS. Lower IRI-FS and IRI-PD scores were found to be significantly related to high suicide risk in depression.Conclusion: Based on our results, patients with major depressive disorder show significantly impaired empathy measures compared to the normal population. Our findings also suggest a close relationship between suicidality and empathy in patients with MDD.Keywords: Empathy, gender, hopelessness, major depressive disorder, suicide ÖZET Majör depresif bozukluğu olan hastalarda empati yanıtı ve klinik özelliklerle ilişkisiAmaç: Bildiğimiz kadarıyla majör depresif bozukluklu hastalarda empatik cevaplarla klinik özellikler arasındaki ilişkiyi araştıran herhangi bir çalışma yoktur. Amacımız majör depresif bozukluklu hastalarda duygusal ve bilişsel empati cevabını değerlendirmek ve empatinin klinik özelliklerle olan muhtemel ilişkisini araştırmaktır. Sonuç: Bulgularımıza dayanarak depresif bozukluklu hastalarda normal popülasyona göre anlamlı olarak bozulmuş empati ölçümleri olduğu söylenebilir. Ayrıca bulgularımız depresif olgularda intihar ve empati arasında yakın bir ilişki olduğuna işaret etmektedir.

show abstract

“…Studies suggest significantly heightened suicidal deaths in depression [2][3][4], bipolar disorder [5,6], schizophrenia [7,8] substance use disorder [8,9], alcohol use disorder [10,11] and chronic pain [12,13].…”

Section: Introductionmentioning

confidence: 99%