Suicide Risk Following Child Sexual Abuse

Plunkett, Angela; O’Toole, Brian I.; Swanston, Heather Y.; Oates, R. K.; Shrimpton, Sandra; Parkinson, Patrick

doi:10.1367/1539-4409(2001)001<0262:srfcsa>2.0.co;2

Cited by 79 publications

(55 citation statements)

References 20 publications

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“…At the outset of this article, we highlighted that prior research has linked adverse childhood experiences to attempted suicide (Brown et al 1999;Plunkett et al 2001), but this line of research has been slow to examine the potential intervening mechanisms linking this relationship. In fact, only a few of these studies have considered any mediator variables (Dube et al 2001;Roy 2005) and, to the best of our knowledge, none have examined the mediating effects of multiple maladaptive personality traits and adolescent problem behaviors in the context of this association.…”

Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences and Suicide Attempts: The Mediating Influence of Personality Development and Problem Behaviors

Perez

Jennings

Piquero

et al. 2016

J Youth Adolescence

100

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Adverse childhood experiences, comprised of forms of maltreatment and certain dysfunctional household environments, can affect the development of a child in a variety of different ways. This multitude of developmental changes may subsequently produce compounding harmful effects on the child's life and increase acutely maladaptive outcomes, including adolescent suicidal behavior. This study uses data collected from 2007 to 2012 for 64,329 Florida Department of Juvenile Justice youth (21.67 % female, 42.88 % African American, and 15.37 % Hispanic) to examine the direct and indirect effects of adverse childhood experiences on suicide attempts. Using a generalized structural equation model, the effects of adverse childhood experience scores are estimated on suicidal behavior through pathways of certain aspects of a child's personality development (aggression and impulsivity), as well as adolescent problem behaviors (school difficulties and substance abuse). The results show that a large proportion of the relationship between childhood adversity and suicide is mediated by the aforementioned individual characteristics, specifically through the youth's maladaptive personality development. These results suggest that, if identified early enough, the developmental issues for these youth could potentially be addressed in order to thwart potential suicidal behavior.

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Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences and Suicide Attempts: The Mediating Influence of Personality Development and Problem Behaviors

Perez

Jennings

Piquero

et al. 2016

J Youth Adolescence

100

View full text Add to dashboard Cite

show abstract

“…Adolescents who have been brought into care may also have experienced child sexual abuse. Unfortunately, research indicates this population's suicide rate is 10-13 times greater than the general population for the same age group (Plunkett et al 2001). Child welfare efforts to protect children who have been abused or maltreated may not protect them from suicidality.…”

Section: Practice Settings and Populations Served By Cyc Professionalsmentioning

confidence: 97%

Mental Health Literacy: A Conceptual Framework for Future Inquiry into Child and Youth Care Professionals’ Practice with Suicidal Adolescents

Ranahan

2009

Child Youth Care Forum

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“…More recently, a number of environmental factors have been found to act as contributory factory in suicide vulnerability, including maternal stress, childhood maltreatment, traumatic events, and exposure to stress (Lopizzo et al, 2015). It has been argued that adverse life events such as early life stress or traumatic exposure can cause gene x environment interaction with a result in improper functioning of neuronal circuitry, which can lead to an early onset of MDD and can increase susceptibility to suicidal behavior (Brezo et al, 2008; Martin et al, 2004; Menke and Binder, 2014; Plunkett et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation

Roy

Shelton

Dwivedi

2017

Journal of Psychiatric Research

108

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Stress plays an important role in major depressive disorder (MDD) and is one of the state dependent factors in suicidal behavior. A dysfunctional hypothalamic-pituitary-adrenal axis is a common feature in this disorder. The involvement of environmental factors has added additional complexity to understanding depression or suicidal behavior. In this regard, epigenetic regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network that may increase susceptibility to depression or suicidal behavior. The present study examined whether epigenetic modifications of stress related genes are associated with MDD and whether there are differences in these epigenetic marks between depressed individuals with and without serious suicidal ideation. Using MeDIP analysis in genomic DNA isolated from peripheral blood mononuclear cells (PBMC) of healthy controls (n=20), MDD patients with (n=14) or without serious suicidal ideation (n=10), we studied methylation of the stress-associated genes Brain Derived Neurotrophic Factor (BDNF), Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1), FK506 Binding Protein 5 (FKBP5), Corticotropin Releasing Hormone Binding Protein (CRHBP), and Corticotropin Releasing Hormone Receptor 1 (CRHR1) . In addition, we determined their transcript levels in RNAs isolated from the same PBMC. We found that BDNF, FKBP5, CRHBP, and NR3C1 gene promoters were significantly hypermethylated in MDD patients with and without suicidal ideation. We also found concomitant reductions in expression of BDNF, FKBP5 transcript variants (1, 2 and 3), and NR3C1 genes in these patients, suggesting that promoter hypermethylation in these genes may functionally be associated with their observed downregulation in MDD patients. In a secondary analysis, methylation of these genes was compared between MDD patients with or without serious suicidal ideation and controls. The MDD with serious suicidal ideation were significantly different from controls while the MDD without were not, although MDD with or without suicidal ideation were not different from each other, likely owning to a relatively small sample size. Thus, our findings underline the importance of epigenetic modifications of stress-associated genes in depression and, possibly, suicidal behavior, which, in future, needs to be confirmed in a larger patient population.

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Suicide Risk Following Child Sexual Abuse

Cited by 79 publications

References 20 publications

Adverse Childhood Experiences and Suicide Attempts: The Mediating Influence of Personality Development and Problem Behaviors

Adverse Childhood Experiences and Suicide Attempts: The Mediating Influence of Personality Development and Problem Behaviors

Mental Health Literacy: A Conceptual Framework for Future Inquiry into Child and Youth Care Professionals’ Practice with Suicidal Adolescents

DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation

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