Suicide risk among individuals at Ultra-High Risk (UHR) of psychosis in a developing North African country: A 12-month naturalistic prospective cohort study from the TRIP project

Fekih‐Romdhane, Feten; Abassi, B.; Ghrissi, F.; Loch, Alexandre Andrade; Chérif, W.; Damak, R.; Ellini, S.; Hallit, Souheil; Cheour, Majda

doi:10.1016/j.psychres.2023.115409

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…The multilayered crisis has led to multiple negative consequences in Lebanese clinical populations, including an increase in the rates of depressive symptoms [ 37 ]. At the same time, prevention and research efforts regarding depression in schizophrenia are still poorly developed or inappropriate in this part of the world [ 38 ]. This considerable early detection and intervention gap may be mainly attributed to a very limited number of mental health professionals and a budget allowed for mental health that is “far below the range to promote mental health services” [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Validation and optimal cut-off score of the World Health Organization Well-being Index (WHO-5) as a screening tool for depression among patients with schizophrenia

Fekih-Romdhane,

Al Mouzakzak,

Abilmona

et al. 2024

BMC Psychiatry

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Background The utility of the World Health Organization Wellbeing Index (WHO-5) as rapid screening tool for depression has not yet been researched in the context of schizophrenia. The goals of this study were twofold: (1) to test the psychometric properties of the WHO-5 in a sample of Arabic-speaking patients with schizophrenia from Lebanon, with particular emphasis on validating the WHO-5 as a screening tool for wellbeing and depression in patients with schizophrenia; and (2) to determine the optimal cut-off point to identify schizophrenia patients with depression. Methods Chronic, remitted patients with schizophrenia took part in this cross-sectional study between August and October 2023 (n = 117; mean age of 57.86 ± 10.88 years and 63.3% males). The Calgary Depression Scale for Schizophrenia (CDSS) was included as index of validity. For the validation of the WHO-5 scale, we performed a confirmatory factor analysis (CFA) using the original structure of the scale. To assess the discriminatory validity of the Arabic version of the WHO-5 as a screening tool for depression, we conducted a Receiver operating characteristic (ROC) curve analysis, taking the WHO-5 reversed score against the dichotomized CDSS score at a cut off value of 6. Results The results of CFA supported the originally proposed unidimensional structure of the measure, with good internal consistency reliability (α = 0.80), concurrent validity, and cross-sex measurement invariance. The WHO-5 showed a sensitivity of 0.8 and a specificity of 0.7 in the detection of depression with a cut-off point of 9.5. The validity of the WHO-5 as a screening tool for depression was supported by the excellent discrimination AUC value of 0.838. Based on this WHO-5 cut-off value, 42.6% of the patients were screened as having a depression. Conclusion The study contributes to the field by showing that the WHO-5 is a concise and convenient self-report measure for quickly screening and monitoring depressive symptoms in patients with schizophrenia. It is therefore highly recommended to apply this cut-off point for screening and follow-up assessments. The current findings will hopefully encourage clinicians and researchers working in Arab settings, who are often confronted with significant time and resource constraints, to start using the WHO-5 to aid their efforts in mitigating depression in this vulnerable population and fostering research in this under-researched area.

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Section: Introductionmentioning

confidence: 99%

Validation and optimal cut-off score of the World Health Organization Well-being Index (WHO-5) as a screening tool for depression among patients with schizophrenia

Fekih-Romdhane,

Al Mouzakzak,

Abilmona

et al. 2024

BMC Psychiatry

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“…While strong efforts have been made over the last years in prevention and early intervention for psychosis in several countries, such efforts are still largely inadequate or completely lacking in others. In some parts of the world, such as the Middle East and North Africa (MENA) region, early intervention in psychosis services and research in this area are still emerging [e.g., The Tunisian Center of Early Intervention in Psychosis (TCEIP) ( 9 )]. There have been some very recent attempts to advance early intervention in countries where the progress in this field remains slow, by investigating subclinical PEs in the general population [e.g., ( 3 , 10 )], or by translating and validating essential measurement tools in the field in local languages [e.g., the Prodromal Questionnaire-Brief in Arabic ( 11 ), the Psychosis Screening Questionnaire in sub-Saharan African languages ( 12 )].…”

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confidence: 99%

Editorial: Psychotic experiences and symptoms in adolescents and young adults from different countries and cultural backgrounds

Fekih-Romdhane,

Obeid,

Hallit

2023

Front. Psychiatry

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Impulsivity as a predictor of clinical and psychological outcomes in a naturalistic prospective cohort of subjects at ultra-high risk (UHR) for psychosis from Tunisia

Fekih-Romdhane,

Ghrissi,

Abassi

et al. 2024

Psychiatry Research

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Suicide risk among individuals at Ultra-High Risk (UHR) of psychosis in a developing North African country: A 12-month naturalistic prospective cohort study from the TRIP project

Cited by 5 publications

References 59 publications

Validation and optimal cut-off score of the World Health Organization Well-being Index (WHO-5) as a screening tool for depression among patients with schizophrenia

Validation and optimal cut-off score of the World Health Organization Well-being Index (WHO-5) as a screening tool for depression among patients with schizophrenia

Editorial: Psychotic experiences and symptoms in adolescents and young adults from different countries and cultural backgrounds

Impulsivity as a predictor of clinical and psychological outcomes in a naturalistic prospective cohort of subjects at ultra-high risk (UHR) for psychosis from Tunisia

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