Suicide Probability Among Tramadol Addicts

Mohamed, Ahmed Saad; Ibrahim, Nesreen M.; Mazloum, A.; Naguib, Rehab; Azzam, Lobna

doi:10.1097/adt.0000000000000222

Cited by 2 publications

(2 citation statements)

References 22 publications

(20 reference statements)

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“…In line with our result, Artenie et al (2014) revealed that the main risk factor for suicide attempt among addict was increase duration of substance use [27]. Another study confirmed our result, revealed that the duration of tramadol use could be considered a strong risk factor for suicide, as increasing the duration of tramadol results in increasing suicide risk [28]. The effects of comorbid psychiatric disorders including major depression disorder, generalized anxiety disorder…”

Section: Discussionsupporting

confidence: 87%

Suicidal ideation and behavior among subjects with substance abuse disorder related to pregabalin

Ibrahim

Bayomy

Hussein

et al. 2022

Middle East Curr Psychiatry

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Background Although pregabalin abuse is increasing worldwide and may be associated with increased suicidal ideation and behavior, few studies were done in Egypt searching for the effect of pregabalin on suicide. Eighty-three patients meeting DSM-IV criteria for substance abuse disorders related to pregabalin were identified from the addiction clinic of EL Khanka Psychiatric Hospital in Egypt for this observational cross–sectional study. We intended to assess suicidal ideation and behavior in patients with substance abuse disorder related to pregabalin and to identify the effects of other comorbid substances of abuse. All participants were subjected to semi-structured interview designed to collect and identify the socio-demographic data and patterns of substances 'use ,The Structured Clinical Interview for DSM-IV Axis I Disorders to diagnose patients with substance abuse disorder “related to pregabalin,” Beck Scale for Suicidal Ideation for assessment of suicidal ideation and behavior and urine screening test for pregabalin and other substances of abuse. Results Most of participants used pregabalin continuously {86.7%}. More than seventy nine percent of the patients abused both pregabalin and other substances, tramadol 67.4%, heroin 66.3%, cannabis 65.1%, other drugs 44.6%, and benzodiazepines 27.7%. Screening urine test was positive in 62.7% of participants most frequently was heroin 41% and cannabis 34.9%. No suicidal ideation was found in 67.4%, 19.3% had low risk of suicide, and 13.3% had high risk of suicide so total participants who had suicidal ideation were 32.6%. There was statistical significant increase in risk of suicide among patients who were continuously abusing pregabalin and who had positive pregabalin urine test. There was significant positive correlation between Beck Suicidal Ideation score and duration of abusing pregabalin, maximum and daily dose of pregabalin. Also, there was a statistical significant relation between suicidal ideation and associated tramadol abuse and this was positively correlated with dose and duration of tramadol abuse. Conclusions About one third of patients abusing pregabalin had a risk of suicide and this risk increased with associated tramadol abuse so pregabalin abuse is dangerous like other substances of abuse and must be used with caution under strict medical supervision

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Section: Discussionsupporting

confidence: 87%

Suicidal ideation and behavior among subjects with substance abuse disorder related to pregabalin

Ibrahim

Bayomy

Hussein

et al. 2022

Middle East Curr Psychiatry

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“…The length of time pregabalin was abused for, the highest amount taken, and the amount used daily were all positively correlated with the Beck Suicidal Ideation score. Suicidal ideation was also positively correlated with both the dose and duration of tramadol misuse, suggesting a causal relationship between the two (30) .…”

Section: Medical and Psychiatric Comorbiditiesmentioning

confidence: 91%

Medical and Psychiatric Comorbidity in Patients with Pregabalin Abuse: Review Article

Ibrahim¹,

Abdelaziz²

2022

The Egyptian Journal of Hospital Medicine

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Background: Anxiety, sadness, personality disorders, and suicide are just some of the common psychiatric conditions that often co-occur with pregabalin addiction. Pregabalin (PGB) is one of many psychoactive prescription medications that has seen a rise in its off-label use in recent years. Multiple drug users and patients in methadone treatment programs have been found to take PGB at high quantities to enhance the effects of methadone, alleviate withdrawal symptoms, or both. This is why high-risk populations need precise toxicological monitoring. Objective: This review article aimed to study prevalence of medical and psychiatric comorbidity in patients with pregabalin Abuse. Methods: Medical, psychiatric comorbidity and the pregabalin abuse were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from March 2008 to January 2022 was included. Due to the lack of sources for translation, documents in languages other than English have been ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusions: Pregabalin abuse was associated with medical illnesses such as neuropathy and epilepsy and psychiatric disorders such as anxiety and depression.

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Suicide Probability Among Tramadol Addicts

Cited by 2 publications

References 22 publications

Suicidal ideation and behavior among subjects with substance abuse disorder related to pregabalin

Suicidal ideation and behavior among subjects with substance abuse disorder related to pregabalin

Medical and Psychiatric Comorbidity in Patients with Pregabalin Abuse: Review Article

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