Suicide in treatment-refractory depression

Potentiation strategies for treatment‐resistant depression

“…Subsequent revisions (8, 9) established the basic criteria for classifying treatment‐resistant depression:…”

Deep Brain Stimulation for Treatment-Resistant Depression

“…Treatment-resistant depression therefore has a U.S. prevalence of 2%–5%. Continued depressive symptoms are associated with ongoing functional impairment (4), increased utilization of health care resources (5), a greater risk of suicide (6), and an overall increased mortality (7). …”

Advances in the Management of Treatment-Resistant Depression

“…A variety of antidepressant treatments are available, but many patients fail to achieve sustained symptomatic remission. Continued depressive symptoms are associated with ongoing functional impairment (2), increased usage of health care resources (3), a greater risk of suicide (4–6), and overall increased mortality, especially associated with cardiovascular disease (7–10). …”