Suicide in patients with gastric cancer: a population-based study

Sugawara, Akitomo; Kunieda, Etsuo

doi:10.1093/jjco/hyw075

Cited by 11 publications

(32 citation statements)

References 28 publications

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“…Demographic information collected included age at cancer diagnosis (continuous), sex, socioeconomic status (operationalized as a quintile of the median neighborhood income), geographical region (operationalized by 14 health regions within Ontario), rurality (yes vs no), year of diagnosis (by tertiles), and general comorbidity (Johns Hopkins Aggregate Disease Group [ADG] 38 ), operationalized as low (≤5), intermediate (6)(7)(8)(9), and high (≥10). The Johns Hopkins ADG is based on previous health care use and has better discrimination than the Charlson score in comorbidity assessment.…”

Section: Identification Of Patients With Cancermentioning

confidence: 99%

“…Previous studies have established that suicide rates are higher among patients who have cancer compared with the general population, with specific risk factors (arguably strongest to weakest) including male gender, advanced disease, Caucasian race, and unmarried status . Furthermore, a psychiatric comorbidity is a strong risk factor for suicidal death .…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Furthermore, approximately 70% of suicides occurring in patients aged >60 years are associated with medical illness, with higher rates among patients who have cancer. Malignancies that are associated with a particularly high risk of suicidal death include head and neck cancers, 4,8 bladder cancer, 5,21,27 lung cancer, 4,[24][25][26] foregut cancers, 4,6,15,19,26 and gynecologic malignancies. 11,14 Previous studies have established that suicide rates are higher among patients who have cancer compared with the general population, with specific risk factors (arguably strongest to weakest) including male gender, advanced Cancer August 15, 2019 disease, Caucasian race, and unmarried status.…”

Section: Introductionmentioning

confidence: 99%

“…11,14 Previous studies have established that suicide rates are higher among patients who have cancer compared with the general population, with specific risk factors (arguably strongest to weakest) including male gender, advanced Cancer August 15, 2019 disease, Caucasian race, and unmarried status. 5,6,15,21,25,26 Furthermore, a psychiatric comorbidity is a strong risk factor for suicidal death. [28][29][30] However, to our knowledge, no studies to date have assessed the relationship of a cancer diagnosis and the risk of suicide while considering the role of a prior psychiatric diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, approximately 70% of suicides occurring in patients aged >60 years are associated with medical illness, with higher rates among patients who have cancer . Malignancies that are associated with a particularly high risk of suicidal death include head and neck cancers, bladder cancer, lung cancer, foregut cancers, and gynecologic malignancies …”

Section: Introductionmentioning

confidence: 99%

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Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies

Klaassen

Wallis

Chandrasekar

et al. 2019

Cancer

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Background Previous studies have demonstrated an association between a diagnosis of cancer and the risk of suicide; however, they failed to account for psychiatric care before a cancer diagnosis, which may confound this relationship. The objective of this study was to assess the effect of a cancer diagnosis on the risk of suicide, accounting for prediagnosis psychiatric care utilization. Methods All adult residents of Ontario, Canada who were diagnosed with cancer (1 of prostate, breast, colorectal, melanoma, lung, bladder, endometrial, thyroid, kidney, or oral cancer) between 1997 and 2014 were identified. Noncancer controls were matched 4:1 based on sociodemographics, including a psychiatric utilization gradient (PUG) score (with 0 indicating none; 1, outpatient; 2, emergency department; and 3, hospital admission). A marginal, cause‐specific hazard model was used to assess the effect of cancer on the risk of suicidal death. Results Among 676,470 patients with cancer and 2,152,682 matched noncancer controls, there were 8.2 and 11.4 suicides per 1000 person‐years of follow‐up, respectively. Patients with cancer had an overall higher risk of suicidal death compared with matched patients without cancer (hazard ratio, 1.34; 95% CI, 1.22‐1.48). This effect was pronounced in the first 50 months after cancer diagnosis (hazard ratio, 1.60; 95% CI, 1.42‐1.81); patients with cancer did not demonstrate an increased risk thereafter. Among individuals with a PUG score 0 or 1, those with cancer were significantly more likely to die of suicide compared with controls. There was no difference in suicide risk between patients with cancer and controls for those who had a PUG score of 2 or 3. Conclusions A cancer diagnosis is associated with increased risk of death from suicide compared with the general population even after accounting for precancer diagnosis psychiatric care utilization. The specific factors underlying the observed associations remain to be elucidated.

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Section: Identification Of Patients With Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies

Klaassen

Wallis

Chandrasekar

et al. 2019

Cancer

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Suicide risk following a new cancer diagnosis among Veterans in Veterans Health Administration care

et al. 2022

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Background Cancer diagnoses are associated with an increased risk for suicide. The aim of this study was to evaluate this association among Veterans receiving Veterans Health Administration (VHA) care, a population that has an especially high suicide risk. Methods Among 4,926,373 Veterans with VHA use in 2011 and in 2012 or 2013, and without VHA cancer diagnoses in 2011, we assessed suicide risk following incident cancer diagnoses. Risk time was from initial VHA use in 2012–2013 to 12/31/2018 or death, whichever came first. Cox proportional hazards regression models evaluated associations between new cancer diagnoses and suicide risk, adjusting for age, sex, VHA regional network, and mental health comorbidities. Suicide rates were calculated among Veterans with new cancer diagnoses through 84 months following diagnosis. Results A new cancer diagnosis corresponded to a 47% higher suicide risk (Adjusted Hazard Ratio [aHR] = 1.47, 95% CI: 1.33–1.63). The cancer subtype associated with the highest suicide risk was esophageal cancer (aHR = 6.01, 95% CI: 3.73–9.68), and other significant subtypes included head and neck (aHR = 3.55, 95% CI: 2.74–4.62) and lung cancer (aHR = 2.35, 95% CI: 1.85–3.00). Cancer stages 3 (aHR = 2.36, 95% CI: 1.80–3.11) and 4 (aHR = 3.53, 95% CI: 2.81–4.43) at diagnosis were positively associated with suicide risk. Suicide rates were highest within 3 months following diagnosis and remained elevated in the 3–6‐ and 6–12‐month periods following diagnosis. Conclusion Among Veteran VHA users, suicide risk was elevated following new cancer diagnoses. Risk was particularly high in the first 3 months. Additional screening and suicide prevention efforts may be warranted for VHA Veterans newly diagnosed with cancer.

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Gastrointestinale Erkrankungen

Kapfhammer¹

2022

Depression, Angst, Traumatischer Stress Und Internistische Erkrankungen

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Suicide in patients with gastric cancer: a population-based study

Cited by 11 publications

References 28 publications

Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies

Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies

Suicide risk following a new cancer diagnosis among Veterans in Veterans Health Administration care

Gastrointestinale Erkrankungen

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