Suicide Gene Therapy

Enhancement of Anti-tumor Activity of Newcastle Disease Virus by the Synergistic Effect of Cytosine Deaminase

“…5-FU is a common moderately toxic anti-tumor drug for treating the digestive system cancers, liver cancer, breast cancer and other cancers in clinic, 5-FU has low toxicity to the normal cells, tissues and organs (Huber et al, 1994). 5-FU in the cancer cells is converted to 5-FUMP, the substance can combine with reduced tetrahydrofolic acid and thymidylate synthetase (TS) as a trimer to inactivate TS and prevent deoxyuridine acid from changing into deoxythymidine acid, which in turn inhibits DNA synthesis to achieve the goal of tumor inhibition (Springer, 1996;Arica et al, 2002;Springer et al, 2004;Kaliberova et al, 2008). In previous studies, some cytokines were expressed in recombinant NDV vectors, which are uncontrollable and may cause some unexpected side effects.…”

Synthesis and Antitumor Activity of Novel Nitrogen Mustard‐Linked Chalcones

“…In the past several years, designs and modifications of the structure of nitrogen mustards to increase their cytotoxicity, especially for their specificity toward tumor cells, have been in the focus of interest of many biochemists 24–26. But, to the best of our knowledge, there have so far been no literature reports regarding nitrogen mustard‐containing chalcone derivatives in which the N , N ‐bis(2‐chloroethyl)amine pharmacophore was linked to the chalcone framework.…”