Suicide attempts in adult patients with idiopathic generalized epilepsy

Hara, Eriko; Akanuma, Nozomi; Adachi, Naoto; Hara, Koichiro; Koutroumanidis, Michael

doi:10.1111/j.1440-1819.2009.01932.x

Cited by 18 publications

(19 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Epilepsy affects physical, mental and behavioral functions and is associated with higher risk of premature death due to traumatic brain injury [3], [4], status epilepticus, suicide, pneumonia and sudden death, and it accounts for 1.4% of all years of life lost [5], [6]. A study found 4.8% of patients with idiopathic generalized epilepsy (IGE) had attempted suicide, a much higher rate than that of the general population [7]–[9]. These suicidal patients were diagnosed with one or more psychiatric disorders [7].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Chang

Liao

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

BackgroundPsychiatric manifestations after occurrence of epilepsy have often been noted. However, the association between newly diagnosed epilepsy and psychiatric disorders afterward is not completely understood. We conducted two longitudinal cohorts for patients with and without epilepsy to investigate the risk factors and hazard ratios of developing psychiatric disorders after patients were newly diagnosed with epilepsy.MethodsWe identified 938 patients with a new diagnosis of epilepsy and 518,748 participants without epilepsy from the National Health Insurance Research Database in 2000–2002 and tracked them until 2008. We compared the incidence of developing psychiatric disorders between the two cohorts, evaluated risk factors and measured the associated hazard ratios (HRs) and 95% confidence intervals (CIs) of developing psychiatric disorders.FindingsThe incidences of psychiatric disorders for people with and without epilepsy were 94.1 and 22.6 per 1000 person-years, respectively. After adjusting the covariates, the epilepsy cohort showed the highest risks in mental retardation (HR 31.5, 95% CI 18.9 to 52.4), bipolar disorder (HR 23.5, 95% CI 11.4 to 48.3) and alcohol or drug psychosis (HR 18.8, 95% CI 11.1 to 31.8) among psychiatric complications developed after newly diagnosed epilepsy. The risk increased with epileptic general seizure and frequency of outpatient visits for epilepsy, as well as with emergency room visits and hospitalizations for epilepsy, and with older age. Chronologically, the highest risk occurred in the first year after epilepsy diagnosis (HR 11.4, 95% CI 9.88 to 13.2).ConclusionVarious psychiatric disorders were demonstrated after newly diagnosed epilepsy and closely related to general seizure and use of medical services for epilepsy. This shows a need for integrated psychiatric care for patients newly diagnosed with epilepsy, especially in the first year.

show abstract

Section: Introductionmentioning

confidence: 99%

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Chang

Liao

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…This hypothesis seems to be supported by epidemiological data suggesting that people with a history of suicidal behavior have a fivefold higher risk of developing epilepsy [34]. Results about epilepsy-related variables are, however, still contradictory [35]. What is already established is that, in some selected cases, intense suicidal ideation can occur as a post-ictal event.…”

Section: Suicide In Epilepsymentioning

confidence: 93%

Suicide and epilepsy: do antiepileptic drugs increase the risk?

Mula

Sander

2015

Expert Opinion on Drug Safety

View full text Add to dashboard Cite

show abstract

“…Some authors have suggested that the rate of suicide is higher in people with temporal lobe epilepsy 15. Idiopathic generalized epilepsy has recently been studied with both retrospective and prospective methods in 145 consecutive adults 19. No epilepsy-related factors were associated with suicide attempts while all index cases had a current psychiatric disorder (mood disorders, neurotic disorders, or personality disorders) and psychosocial events were considerably relevant.…”

Section: Epilepsy Depression and Suicide: What Is The Role Of Aeds?mentioning

confidence: 99%

Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence

Mula¹

2011

DHPS

View full text Add to dashboard Cite

Two years after the warning issued by the Food and Drug Administration on an increased risk of suicide for people taking antiepileptic drugs (AEDs), a number of pharmacoepidemiologic studies have been published but the scientific community is far from definitive answers. The present paper is aimed at reviewing available evidence on the association between AEDs and suicidal behavior, discussing major variables involved such as the relationship between epilepsy, depression, and suicide and the psychotropic potential of AEDs. All studies published so far show a lack of concordance and are constrained by various methodological limitations. What seems to be established is that mood disorders represent a frequent comorbidity in epilepsy and suicide is a serious complication more frequently encountered in epilepsy rather than in the general population. Moreover, a subgroup of patients appears to be at risk of developing treatment-emergent psychiatric adverse effects of AEDs independently of the specific mechanism of action of the drug. The prior history of suicide attempt, especially preceding the onset of the epilepsy, may represent a key element explaining why what is observed is independent of the specific mechanism of the drug. In general terms, risks associated with stopping, or not even starting, AEDs in epilepsy might well be in excess of the risk of suicide in epilepsy, as deaths due to accident and epilepsy itself may predominate. Clinicians need to pay attention not only to seizure patterns when choosing the appropriate AED but also to a number of different parameters (eg, age, gender, working needs, medical comorbidities, history of psychiatric disorders, and suicidality before epilepsy onset) and not the least the mental state of the patient. Missing severe complications such as suicidal behavior or delaying its treatment may worsen the prognosis of epilepsy.

show abstract

Suicide attempts in adult patients with idiopathic generalized epilepsy

Cited by 18 publications

References 19 publications

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study

Suicide and epilepsy: do antiepileptic drugs increase the risk?

Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence

Contact Info

Product

Resources

About