Suicide and Murder-Suicide Involving Aircraft

Kenedi, Christopher A.; Friedman, Susan Hatters; Watson, Dougal B.; Preitner, Claude

doi:10.3357/amhp.4474.2016

Cited by 26 publications

(32 citation statements)

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“…Despite these limitations, the present study has shed new light on blood biomarker screening of SOD by plasma metabolites. Evaluating severity of depression (SOD), especially suicidal ideation (SI), is crucial not only in psychiatric settings but also primary care and social situations to prevent suicidal incidents [64, 65], and hopefully SOD and SI evaluation systems with plasma metabolites will be developed for use in simple and easy evaluation kits for clinical practices and at medical checkups in the future.…”

Section: Discussionmentioning

confidence: 99%

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

et al. 2016

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Evaluating the severity of depression (SOD), especially suicidal ideation (SI), is crucial in the treatment of not only patients with mood disorders but also psychiatric patients in general. SOD has been assessed on interviews such as the Hamilton Rating Scale for Depression (HAMD)-17, and/or self-administered questionnaires such as the Patient Health Questionnaire (PHQ)-9. However, these evaluation systems have relied on a person’s subjective information, which sometimes lead to difficulties in clinical settings. To resolve this limitation, a more objective SOD evaluation system is needed. Herein, we collected clinical data including HAMD-17/PHQ-9 and blood plasma of psychiatric patients from three independent clinical centers. We performed metabolome analysis of blood plasma using liquid chromatography mass spectrometry (LC-MS), and 123 metabolites were detected. Interestingly, five plasma metabolites (3-hydroxybutyrate (3HB), betaine, citrate, creatinine, and gamma-aminobutyric acid (GABA)) are commonly associated with SOD in all three independent cohort sets regardless of the presence or absence of medication and diagnostic difference. In addition, we have shown several metabolites are independently associated with sub-symptoms of depression including SI. We successfully created a classification model to discriminate depressive patients with or without SI by machine learning technique. Finally, we produced a pilot algorithm to predict a grade of SI with citrate and kynurenine. The above metabolites may have strongly been associated with the underlying novel biological pathophysiology of SOD. We should explore the biological impact of these metabolites on depressive symptoms by utilizing a cross species study model with human and rodents. The present multicenter pilot study offers a potential utility for measuring blood metabolites as a novel objective tool for not only assessing SOD but also evaluating therapeutic efficacy in clinical practice. In addition, modification of these metabolites by diet and/or medications may be a novel therapeutic target for depression. To clarify these aspects, clinical trials measuring metabolites before/after interventions should be conducted. Larger cohort studies including non-clinical subjects are also warranted to clarify our pilot findings.

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Section: Discussionmentioning

confidence: 99%

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

et al. 2016

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“…Kenedi, Friedman, Watson, and Preitner () examined 65 cases of pilot suicide, of which 18 were determined to have been H‐Ss resulting in 732 deaths. Of these H‐Ss by aircraft, 13 were perpetrated by the pilots themselves.…”

Section: Females In the Bipartite Classification Of Homicide‐suicidementioning

confidence: 99%

“…Another 22% had taken prescription drugs, including medications such as antidepressants for their chronic health issues, and 38% were reported as having a psychiatric condition (Bills et al, 2005). Kenedi, Friedman, Watson, and Preitner (2016) examined 65 cases of pilot suicide, of which 18 were determined to have been H-Ss resulting in 732 deaths. Of these H-Ss by aircraft, 13 were perpetrated by the pilots themselves.…”

Section: Aircraft Homicide-suicidementioning

confidence: 99%

Gender differences in combined homicide‐suicide with consideration of female terrorist bombers

Felthous

Samantarai

Mukhtar

2019

Behavioral Sci & The Law

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Combined homicide‐suicide (H‐S) is a phenomenon described as an offender committing a homicidal act followed by their suicide. Current literature on H‐S is dominated by a focus on men and their particular set of motivations and actions, primarily because females constitute only a small fraction of the cases of completed H‐S. This review begins by analyzing this data and integrating females within two subclassifications of H‐S: the psychopathology of the actor (or perpetrator), and the actor's relationship to her homicide victims. Within the relational subcategory of H‐S, females are: (1) underrepresented when victims are their spouses or intimate partners (consortial H‐S); (2) more prevalent when victims are their own children (filial H‐S); and (3) with rare exceptions, not represented in extrafamilial, adversarial and pseudo‐commando H‐S perpetrators. This review includes female bombers in this gender comparison.

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“…Cinco de los seis eventos de homicidios y suicidios de una muestra de pilotos estudiada por Kennedy y colaboradores sucedieron después de que los responsables se quedaran solos en la cabina y entre los factores asociados se identificaron tanto los conflictos legales como financieros, el estrés ocupacional, las enfermedades mentales y la disfunción de pareja. En el caso del copiloto de Germanwings, todos esos factores, excepto la disfunción de pareja, estuvieron presentes 16 .…”

Section: Discussionunclassified

Asesinato en el aire desde la mente del perpetrador: A bordo del Vuelo 9525 Germanwings

Tejero

Mezo

Díaz

et al. 2019

rmc

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Recibido el 27 de septiembre de 2018; aceptado el 10 de octubre de 2018. RMCOriginal JMM Los autores declaran que el artículo es original y que no ha sido publicado previamente. 147 Rev Med Cine 2019; 15(3): 147-152 Ediciones Universidad de Salamanca / CC BY NC ND J Med Mov 2019; 15(3): 147-152 ResumenLa salud mental es un componente fundamental del bienestar humano, cuando este componente se ve afectado en la vida de un individuo que tiene bajo su responsabilidad la vida de otras personas, nadie está exento de poder sufrir las consecuencias de dicha inestabilidad. Mayday Catástrofes Aéreas: Vuelo 9525 Germanwings -Asesinato en el aire (2016) relata lo acontecido en torno al copiloto responsable de la catástrofe, nos adentra en la mente del perpetrador, situándonos en el contexto en el cual se desenvolvía y permitiéndonos comprender en retrospectiva los puntos fundamentales que pudieron haber servido como señales de alarma y nos invita a reflexionar acerca de las vías de prevención que potencialmente pudieron haberse implementado. Si bien las condiciones orgánicas del copiloto mostraron ser saludables, una combinación de ansiedad y depresión detonadas por la carga laboral y la falta de pertenencia pudieron ser abordadas desde la medicina preventiva y el lifestyle medicine. Los pilotos y copilotos componen un gremio de profesionistas expuestos a estilos de vida que pueden afectar su estabilidad y salud mental y es por ello que se resalta la importancia de la implementación de medidas preventivas, mismas que pudieron aplicarse para evitar la tragedia del Germanwings 9525 que despegó del Aeropuerto de Barcelona con ciento cincuenta personas a bordo, mas nunca llegó a su destino. En el presente artículo se discute la importancia de abordar mediante modelos multinivel la salud de los pilotos y copilotos a propósito del caso del Germanwings, desde el enfoque de la medicina preventiva.Palabras clave: depresión; ansiedad; suicidio; medicina preventiva; lifestyle medicine. SummaryMental health is a fundamental component of human well-being, but when this component is affected in the life of an individual who has the responsibility of other people's lives, no one is exempt from suffering the consequences of such instability. Mayday Air Catastrophes: Flight 9525 Germanwings -Murder in the Air (2016) recounts the events surrounding the co-pilot responsible for the catastrophe, while it takes us into the mind of the perpetrator, placing us in the context in which it developed and allowing us to understand in retrospect the fundamental points that could have served as alarm signals and invites us to reflect on the prevention routes that could potentially have been implemented. Although the organic conditions of the co-pilot showed to be healthy, a combination of anxiety and depression detonated by the workload and the lack of belonging could be addressed from preventive medicine and lifestyle medicine. Pilots and co-pilots make up a guild of professionals exposed to lifestyles that can affect their stability and mental health ...

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Suicide and Murder-Suicide Involving Aircraft

Cited by 26 publications

References 0 publications

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

Gender differences in combined homicide‐suicide with consideration of female terrorist bombers

Asesinato en el aire desde la mente del perpetrador: A bordo del Vuelo 9525 Germanwings

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