Suicidal behaviour and mortality in first-episode psychosis: the
                        OPUS trial

Bertelsen, Mette; Jeppesen, Pia; Petersen, Lone; Thorup, Anne; Øhlenschlæger, Johan; Quach, Phuong le; Christensen, Thomas; Krarup, Gertrud; Jørgensen, Per; Nordentoft, Merete

doi:10.1192/bjp.191.51.s140

Cited by 155 publications

(154 citation statements)

References 16 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…Previous literature has found poor premorbid function to be both a risk factor [39] and a protective factor [29,38] for suicidality. Long DUP has been related to suicidality in FEP [40,41] , while other FEP studies have failed to find this association [17,42] . While longer DUP could explain some of the differences in suicidality between the groups before baseline, it is less certain how much it might contribute to the higher suicide rate in the H group at 5 years of follow-up.…”

Section: Discussionmentioning

confidence: 91%

“…The association between hallucinosis and suicidality is unclear, with a limited number of studies showing hallucinations as a risk factor for suicidality [15,16] . Lately, the OPUS study found that hallucinations at 2 years of follow-up predicted suicidality (plans and attempts) in first-episode psychosis [17] . These studies, however, looked at data cross-sectionally and recorded the number of patients suffering from any one symptom at a particular time rather than showing longitudinal symptom profiles and their separate correlates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contrasting Monosymptomatic Patients with Hallucinations and Delusions in First-Episode Psychosis Patients: A Five-Year Longitudinal Follow-Up Study

Evensen

Røssberg

Haahr³

et al. 2011

Psychopathology

View full text Add to dashboard Cite

time to remission and suicidality. Results: Two groups of patients were identified; H (n = 16) and D (n = 106). 179 patients experienced both hallucinations and delusions (dual symptom group). The H group was significantly younger, had a longer duration of untreated psychosis, poorer premorbid function and better insight than the D group. Notably, the H group scored higher on measures of suicidality, and at 5 years follow-up a significantly higher proportion of patients was lost to suicide in this group. The dual symptom group was closer to the D group on significant parameters, including suicidality and suicide rate. Conclusions: Patients with hallucinations only can be separated from patients with delusions only and the subgroups differ with regard to demographical data, clinical variables and notably with regard to suicidality. These findings suggest distinctions in the underlying biological and psychological processes involved in hallucinations and in delusions. Key WordsHallucinations ؒ Delusions ؒ Psychotic symptoms ؒ Suicide Abstract Background: The main aim of this study was to identify subgroups of patients characterized by having hallucinations only or delusions only and to examine whether these groups differed with regard to demographic characteristics, clinical characteristics and outcome factors, including suicidality. Methods: Out of 301 consecutively admitted patients with first-episode psychosis, individuals with delusions only (D) and hallucinations only (H) were identified based on Positive and Negative Syndrome Scale (PANSS) items P1 (delusions) and P3 (hallucinations) scores at baseline and through 4 follow-up interviews over 5 years. The subgroups were compared with regard to demographic data, premorbid functioning, duration of untreated psychosis, clinical variables,

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Contrasting Monosymptomatic Patients with Hallucinations and Delusions in First-Episode Psychosis Patients: A Five-Year Longitudinal Follow-Up Study

Evensen

Røssberg

Haahr³

et al. 2011

Psychopathology

View full text Add to dashboard Cite

show abstract

“…Indeed, the available evidence from naturalistic and randomized studies strongly supports the value of specialized early psychosis programs in improving outcome in the short term (89,93). If these programs are only provided for 1-2 years, there is also evidence that some of the gains are eroded, suggesting that, for a substantial subset at least, specialized early psychosis care needs to be provided for a longer period, probably up to 5 years in many cases (77,94,95).…”

Section: Next Stepsmentioning

confidence: 99%

Early intervention in psychosis: concepts, evidence and future directions

2008

View full text Add to dashboard Cite

“…Long-term follow up studies have showed that the rate of death by suicide is 5-6% and non-fatal suicidal behavior occurs in approximately 50-60% of patients (Bertelsen et al, 2007;Mauri et al, 2013). Suicide attempts in patients with schizophrenia often occur without warning or verbal expression of intent.…”

Section: Introductionmentioning

confidence: 99%

Clinical variables associated with suicide attempts in schizophrenia before and after the first episode

Togay

Noyan

Taşdelen

et al. 2015

Psychiatry Research

View full text Add to dashboard Cite

Suicidal behaviour and mortality in first-episode psychosis: the OPUS trial

Abstract: In this first-episode cohort depressive and psychotic symptoms, especially hallucinations, predicted suicidal plans and attempts, and persistent suicidal behaviour and ideation were associated with high risk of attempted suicide.

Cited by 155 publications

References 16 publications

Contrasting Monosymptomatic Patients with Hallucinations and Delusions in First-Episode Psychosis Patients: A Five-Year Longitudinal Follow-Up Study

Contrasting Monosymptomatic Patients with Hallucinations and Delusions in First-Episode Psychosis Patients: A Five-Year Longitudinal Follow-Up Study

Early intervention in psychosis: concepts, evidence and future directions

Clinical variables associated with suicide attempts in schizophrenia before and after the first episode

Contact Info

Product

Resources

About