Suicidal behavior in treatment resistant major depressive disorder patients treated with transmagnetic stimulation(TMS) and its relationship with cognitive functions

Ozcan, Selma; Gıca, Şakir; Güleç, Handan

doi:10.1016/j.psychres.2020.112873

Cited by 17 publications

(8 citation statements)

References 55 publications

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“…This result is consistent with existing well-established evidence about the importance of implementing integrated treatments. Moreover, in line with previous findings (Serafini et al, 2015), TMS did not affect cognitive functions and according to Ozcan et al (2020) ameliorated emotion recognition abilities.…”

Section: Summary Of Main Findingssupporting

confidence: 91%

“…Accelerated TMS did not lead to different outcomes than standard TMS, as ECT demonstrated to be more effective than TMS. The most encouraging results in favour of DLPFC rTMS were those of Croarkin et al (2018), Hadley et al (2011), Ozcan et al (2020) and Abdelnaim et al (2020). In the study of Cloarkin et al (2018), the reduction of suicidal risk was found to be mediated by depressive symptoms improvement.…”

Section: Summary Of Main Findingsmentioning

confidence: 97%

“…Response and remission rates at week 5 were 70.6 and 41.2%, respectively. 20 Hz TMS stimulation was also implemented by Ozcan et al (2020) with significant improvements in terms of depression, suicidal idation and behavior and hopelessness in TRD patients. These improvements were not related to the rates of emotion recognition skills that ameliorated, and of cognitive functions that remained stable.…”

Section: Uncontrolled Clinical Trials Ect-controlled Clinical Trials Accelerated Tms-controlled Clinical Trials Retrospective Studiesmentioning

confidence: 99%

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Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Serafini

Canepa

Aguglia

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Summary Of Main Findingssupporting

confidence: 91%

Section: Summary Of Main Findingsmentioning

confidence: 97%

Section: Uncontrolled Clinical Trials Ect-controlled Clinical Trials Accelerated Tms-controlled Clinical Trials Retrospective Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Serafini

Canepa

Aguglia

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Overall, participants showed reduced happy hits and happy false alarms, and increased sad false alarms for ambiguous faces in the iTBS condition. This finding was inconsistent with previous studies that found antidepressants to increase recognition of positive faces (Harmer et al, 2009), as well as other brain stimulation studies which showed an improved affective processing of positive stimuli (Baeken et al, 2011;Nitsche et al, 2012;Ozcan, Gica, & Gulec, 2020). However, Balconi and Canavesio (2016) found a similar reduced performance regarding happy face recognition after TMS stimulation on the left DLPFC.…”

Section: Discussioncontrasting

confidence: 73%

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Dumitru

Rocchi

Saini

et al. 2020

Cogn Affect Behav Neurosci

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Repetitive transcranial magnetic stimulation is a potential treatment option for depression, with the newer intermittent theta-burst stimulation (iTBS) protocols providing brief intervention. However, their mechanism of action remains unclear. We investigated the hypothesis that iTBS influences brain circuits involved in emotion processing that are also affected by antidepressants. We predicted that iTBS would lead to changes in performance on emotion-processing tasks. We investigated the effects of intermittent TBS (iTBS) over the left dorsolateral prefrontal cortex (DLPFC) on the processing of emotional information (word recall and categorization, facial emotion recognition, and decision-making) in 28 healthy volunteers by contrasting these effects with those of sham stimulation. Each volunteer received iTBS and sham stimulation in a blinded crossover design and completed the emotion-processing tasks before and after stimulation. Compared to sham stimulation, iTBS increased positive affective processing for word recall, yet had an unexpected effect on facial emotion recognition for happy and sad faces. There was no evidence of an effect on decision-making or word categorization. We found support for our hypothesis that iTBS influences emotion processing, though some changes were not in the expected direction. These findings suggest a possible common mechanism of action between iTBS and antidepressants, and a complex neural circuitry involved in emotion processing that could potentially be tapped into via brain stimulation. Future research should investigate the neural correlates of emotion processing more closely to inform future iTBS protocols.

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“…The recovery from such typical neurocognitive deficits would possibly have been more marked after a longer follow-up period; they can outlast the remission from characteristic MDD symptoms such as depressed mood and loss of interest for quite some time [54]. Interestingly, a very recent study Neuroimmunomodulation 2020;27:152-162 DOI: 10.1159/000513093 by Ozcan et al [56] also showed an early improvement in emotion recognition in the CANTAB, while cognitive functions such as cognitive flexibility did not markedly improve in patients suffering from treatment-resistant MDD treated with repetitive transcranial magnetic stimulation over 4-6 weeks, similar to our study. For a differentiation of the responder versus nonresponder in cognitive functions along with CCR5/CCL5 levels, the sample size was too small in our study.…”

Section: Discussionmentioning

confidence: 99%

Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment

Bauer

Milenkovic

Hilbert

et al. 2020

Neuroimmunomodulation

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Introduction: Inflammatory processes play an important role in the pathophysiology of major depressive disorder (MDD), but their relevance for specific symptoms such as neurocognitive impairment is rarely investigated. Methods: In this observational study, we investigated the changes of leukocyte chemokine (C-C motif) receptor 5 (CCR5) and ligand 5 (CCL5) mRNA levels and inflammatory cytokines in 60 MDD patients before (PRE) and after 5 weeks (W5) of antidepressive treatment in relation to therapy response and alterations in cognitive functions by means of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We hypothesized that elevated CCR5 and CCL5 levels in depressed patients would decrease upon treatment and could differ with regard to cognitive impairment associated with MDD. Results: Both CCR5 and CCL5 levels were significantly decreased in the responder group compared to nonresponders even before treatment. The cytokine IL-6 as a marker of inflammation in depression did not show a difference before treatment in future responders versus nonresponders, but decreased significantly upon antidepressive therapy. Regarding neurocognitive impairment in MDD patients, an increased misperception of the emotion “anger” after 5 weeks of treatment proved to be associated with a more pronounced change in CCR5, and the perception of the emotion “disgust” became faster along with a stronger decrease in CCL5 over the same time. Executive functions typically impaired in MDD patients were not markedly associated with alterations in CCR5/CCL5. Discussion: CCR5 and CCL5 are important in the targeting of immune cells by HIV. This is the first study providing valuable hints that both CCR5 and CCL5 might also serve as markers of therapy response prediction in MDD. Regarding neurocognitive impairment in depression, CCR5 and CCL5 did not reveal characteristic changes upon MDD treatment such as executive functions, which are probably delayed. However, changes of emotional perception appear to be an earlier responding feature.

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Suicidal behavior in treatment resistant major depressive disorder patients treated with transmagnetic stimulation(TMS) and its relationship with cognitive functions

Cited by 17 publications

References 55 publications

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment

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