Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder—Data from an association study of suicide attempts with clock genes

Pawlak, Joanna; Dmitrzak‐Węglarz, Monika; Maciukiewicz, Małgorzata; Wiłkość, Monika; Leszczyńska-Rodziewicz, Anna; Zaremba, Dorota; Kapelski, Paweł; Hauser, Joanna

doi:10.1016/j.psychres.2015.01.010

Cited by 35 publications

(22 citation statements)

References 30 publications

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“…Moreover, SNPs in TIMELESS gene not only were found correlated with violent suicide attempts but also with the number of suicide attempts during lifetime and with a family history of suicide [83].…”

Section: Circadian Genes and Phenotypic Characteristicsmentioning

confidence: 96%

Chronobiology of Bipolar Disorder: Therapeutic Implication

Dallaspezia

Benedetti

2015

Curr Psychiatry Rep

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Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder arise in part from a malfunction of the circadian system, linking the disease with an abnormal internal timing. Alterations in circadian rhythms and sleep are core elements in the disorders, characterizing both mania and depression and having recently been shown during euthymia. Several human genetic studies have implicated specific genes that make up the genesis of circadian rhythms in the manifestation of mood disorders with polymorphisms in molecular clock genes not only showing an association with the disorder but having also been linked to its phenotypic particularities. Many medications used to treat the disorder, such as antidepressant and mood stabilizers, affect the circadian clock. Finally, circadian rhythms and sleep researches have been the starting point of the developing of chronobiological therapies. These interventions are safe, rapid and effective and they should be considered first-line strategies for bipolar depression.

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Section: Circadian Genes and Phenotypic Characteristicsmentioning

confidence: 96%

Chronobiology of Bipolar Disorder: Therapeutic Implication

Dallaspezia

Benedetti

2015

Curr Psychiatry Rep

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“…Clinically, it has long been known that prior suicide attempts and suicidal ideation are significant distal risk factors for further suicidal behaviors, and, intriguingly, it seems that circadian rhythm genes may be involved in current suicidal behaviors. Indeed, there is preliminary evidence of circadian involvement in suicidal behaviors in BD in association with violent and multiple suicide attempts and where there is a family history of suicide and attempts of suicide . Other implicated gene variants in suicidal behaviors in BD include the rs13515 within the mitogen‐activated protein kinase 1 ( MAPK1 ) gene and the rs6740584 within the cyclic adenosine monophosphate‐responsive element binding protein 1 ( CREB1 ) gene, which appear to be associated with prior suicide attempts .…”

Section: Genetics Epigenetics and Childhood Traumamentioning

confidence: 99%

Modeling suicide in bipolar disorders

et al. 2018

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Suicide is complex, and it is evident that a multidimensional and integrated approach is required to reduce its prevalence. The proposed model exposes and provides access to components of the suicide process that are potentially measurable and may serve as novel and specific therapeutic targets for interventions in the context of bipolar disorder. Thus, this model is useful not only for research purposes, but also for future real-world clinical practice.

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“…This demonstrates not only the impact of genetic variations individually, but how they may interact to create endophenotypes within the BD spectrum . In addition to these factors, Pawlak et al . revealed an association of circadian gene polymorphisms with the occurrence of suicidal behavior in BD, with the main positive findings being associations between selected polymorphic variants and violent suicide attempts ( CLOCK and TIMELESS ), multiple suicide attempts ( TIMELESS ) and family history of suicide attempts ( TIMELESS ).…”

Section: Discussionmentioning

confidence: 98%

“…Thus, it was observed that genetic components of variations in the circadian system, like environmental changes, may affect several physiological systems and produce an increased risk of developing diseases such as cancer, diabetes, depression and sleep problems. Intensive research has been carried out with the aim of understanding how alterations in circadian genes may contribute to modulating behavior and neuropsychiatric disorders such as suicidal behavior, sleep problems, attention deficit hyperactivity disorder and BD …”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder

et al. 2018

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Investigations of the effects of circadian genes have suggested that the chronotype offers hope for guiding and improving management of patients with BD. However, BD is a disease of a complex nature and presents multiple endophenotypes determined by different associations between genetics and the environment. Thus, new genomic studies to delimit variations that may help improve the clinical condition of these patients are extremely important.

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Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder—Data from an association study of suicide attempts with clock genes

Cited by 35 publications

References 30 publications

Chronobiology of Bipolar Disorder: Therapeutic Implication

Chronobiology of Bipolar Disorder: Therapeutic Implication

Modeling suicide in bipolar disorders

Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder

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