Suicidal Attempts and Ideation Among Children and Adolescents in US Emergency Departments, 2007-2015

Abstract

Discussion | Obesity changes the association between total body weight and fat-free mass. The volume of distribution of a medication is therefore variable, according to its lipid solubility, in patients with different BMIs. While alterations in the volume of distribution in individuals with obesity are the result of more complex interactions between drugs, protein binding, and tissue perfusion, this analysis shows that current methods of calculating IBW are an inconsistent surrogate for fat-free mass in children with obesity. For an 11-year-old child with a BMI of 31.0, IBW will be calculated as between 51% and 65% of total body weight. When applied to the prescribing of gentamicin, a hydrophilic drug with a narrow therapeutic index, the starting dose will vary by 27%. Because the lower end of this range is likely to be an underestimation of the child's weight, 6 this is likely to result, at least initially, in the patient receiving subtherapeutic levels of medication. To strive to provide safe, effective dosages of medication for every child, we should seek to develop models incorporating a compartmental approach using, for example, biological impedance. This would help clinicians provide medication dosages to children with obesity ideally.

Annual Research Review: Adolescent mental health in the digital age: facts, fears, and future directions

“…In the United States, there have been rapid and unprecedented increases in adolescent depressive symptoms (Keyes, Gary, O'Malley, Hamilton, & Schulenberg, 2019) and suicidal behavior (Burstein, Agostino, & Greenfield, 2019;Naghavi, 2019). Deaths by suicide have increased among every age group, but have been especially drastic among girls, where there has been a tripling of the suicide rate among 10-to 14-year-old girls from 1999 through 2017 (Hedegaard, Curtin, & Warner, 2018).…”

Serial multiple mediation of the association between internet gaming disorder and suicidal ideation by insomnia and depression in adolescents in Shanghai, China

“…For instance, it increased from 10.4 to 13.6% among grade 8–9 Hong Kong Chinese students according to a 1-year longitudinal study [ 5 ]. Given the rising prevalence and harmful consequences of suicidal ideation, as well as a tendency for suicidal ideation to appear at younger ages [ 6 ], early identification and effective intervention are warranted to reduce adolescent suicidal ideation and its risk factors.…”

Serial Multiple Mediation of the Association Between Internet Gaming Disorder and Suicidal Ideation by Insomnia and Depression in Adolescents in Shanghai, China

“…For instance, it increased from 10.4-13.6% among grade 8-9 Hong Kong Chinese students according to a 1-year longitudinal study (5). Given the rising prevalence and harmful consequences of suicidal ideation, as well as a tendency for suicidal ideation to appear at younger ages (6), early identi cation and effective intervention are warranted to reduce adolescent suicidal ideation and its risk factors.…”