“…This perspective, embodied in the terms “channelopathy” and “channelepsy” (Hoffman, 1995; Ptacek, 1997; De Lanerolle et al, 2004; Kullmann and Waxman, 2010; D'adamo et al, 2013), is fueled by the increasing number of ion channel mutations discovered in epilepsy patients (Biervert et al, 1998; Charlier et al, 1998; Singh et al, 1998, 2008; Zuberi et al, 1999; Heilstedt et al, 2001; Chioza et al, 2002; Schulte et al, 2006; Cavalleri et al, 2007; Tomlinson et al, 2010; Lachance-Touchette et al, 2011; Weckhuysen et al, 2013), and the seizure phenotypes of corresponding engineered channel mutants (Signorini et al, 1997; Schroeder et al, 1998; Smart et al, 1998; Spigelman et al, 2002; Ludwig et al, 2003; Peters et al, 2005; Huang et al, 2009; Ishii et al, 2009; Riazanski et al, 2011; Hedrich et al, 2014). In contrast to genetic channelopathies, an “acquired channelopathy” is declared when ion channel abnormalities develop independently of the genetic background (Waxman, 2001; Bernard et al, 2004; Poolos and Johnston, 2012).…”