Suggestions for uniform outcome variables when reporting treatment effects in hidradenitis suppurativa

Sartorius, Karin; Lapins, Jan; Emtestam, Lennart; Jemec, Gregor B. E.

doi:10.1046/j.1365-2133.2003.05390.x

Cited by 233 publications

(190 citation statements)

References 8 publications

(9 reference statements)

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“…The modified Sartorius score is more dynamic. It is based on the number of areas involved and the number of nodules, fistulas, and hypertrophic scars [10,11]. However, because of its comprehensiveness, it is time consuming, making it less suitable for daily practice.…”

Section: Introductionmentioning

confidence: 99%

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflammatory nodules mostly located in the armpits and groin. Over the years multiple treatments for HS have been proposed; however, to date a cure is still lacking. In this update we provide an overview of most drug treatments reported on for HS, where possible with their mode of action and side effects. In mild cases, clindamycin lotion or resorcinol cream have proven effective. Tetracyclines are a first-line systemic option in more widespread or severe cases, followed by the combination of clindamycin and rifampicin. However, the recurrence rate is high after discontinuation of clindamycin plus rifampicin combination therapy. Long-term treatment with retinoids, especially acitretin is feasible, although teratogenicity has to be taken into account in females of reproductive age. Multiple antiinflammatory drugs have been suggested for HS, such as dapsone, fumarates or cyclosporine. However, their effectiveness in HS is based on small case series with varying results. If most common treatments have failed, biologics (e.g., infliximab or adalimumab) are the next step. Although not addressed in this review, surgical interventions are often needed to achieve remission. Key PointsHidradenitis suppurativa (HS) is a chronic inflammatory skin disease without a cure.Antibiotics (topical or oral) are often the first treatment option for HS.In cases of more extensive or therapy-resistant HS, biologicals (e.g., infliximab or adalimumab) are a good therapeutic option.

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Section: Introductionmentioning

confidence: 99%

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

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“…In order to assess therapy outcomes, we used the Sartorius scale 7 which is in our opinion the most comprehensive tool available for reporting treatment results in patients with AI.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Therapy Outcomes after Negative Pressure Wound Therapy in a Patient with Acne inversa.

Francuzik

Banasiewicz

Adamski

2014

NPWTJ

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Abstract-Treatment of acne inversa (also known as hidradenitis suppurativa) is complicated and chronic. This debilitating, inflammatory disease of the follicular sacks affects mostly young adults and has a strong negative impact on their quality of life. We present a case of a 28 year old woman with a history of acne inversa of Hurley grade 2 for 6 years. Patient underwent surgical excision of the skin of the left inguinum followed by negative pressure therapy dressings for 2 and a half weeks (5 dressing changes). This allowed a full closure of the wound after 12 weeks and formation of a well accepted scar. Patient's pain decreased from 4.5 to 1.5 according to visual assessment scale. We also noted a 28 point decrease in disease severity score according to Sartorius scale and a 19 point decrease in Dermatology Life Quality Index. Two years prior admission patient had undergone surgical treatment of her right inguinum with split thickness skin grafting, which healed for 26 weeks and yielded less satisfactory results. Comparison photographs of both treatment results are presented.

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“…La ventaja de la clasificación de Hurley es la simplicidad; sin embargo, Sartorius et al 15 proponen un sistema que incorpora regiones anatómicas involucradas, número y tipo de lesiones, distancia entre ellas y presencia de piel normal entre lesiones. Agregan una escala visual análoga del dolor y el índice de calidad de vida dermatológico (DLQI).…”

Section: Estadios Clínicosunclassified

Hidrosadenitis supurativa y procesos afines

Herane¹,

Cabrera²

2012

Más Dermatol.

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RESUMENLa hidrosadenitis supurativa (acné inverso, enfermedad de Verneuil, apocrinitis) es una enfermedad crónica que afecta principalmente a zonas intertriginosas, con nódu-los inflamatorios subcutáneos recurrentes, sinus y cicatrices defectuosas. Se considera una enfermedad de oclusión folicular. Las terapias tradicionales consisten en intervenciones quirúrgicas parciales o extensas, antiandrógenos, antibióticos, inhibidores del factor de necrosis tumoral α, terapia fotodinámica y otras.Palabras clave: hidrosadenitis supurativa, acné inverso, enfermedad de Verneuil. ABSTRACTHidradenitis suppurativa (acne inversa, Verneuil disease, apocrinitis) is a chronic disease primarily affecting intertriginous areas with tender subcutaneous nodules, sinus tracts and abnormal scarring. It is considered a disease of follicular occlusion. Traditional therapies consisting of partial and extensive surgery, antiandrogens, antibiotics, tumour necrosis factor inhibitors, photodynamic therapy are available among others.

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Suggestions for uniform outcome variables when reporting treatment effects in hidradenitis suppurativa

Cited by 233 publications

References 8 publications

An Update on Medical Treatment Options for Hidradenitis Suppurativa

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Improvement of Therapy Outcomes after Negative Pressure Wound Therapy in a Patient with Acne inversa.

Hidrosadenitis supurativa y procesos afines

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