Suggestions for Protecting Breast Cancer Patients Receiving Outpatient Chemotherapy and Their Families Against the Exposure Risk from Salivary Cyclophosphamide

Abstract

This is a quantitative descriptive study that investigates the kinetics of salivary CPA in order to minimize the risk of CPA exposure after outpatient chemotherapy. Another aim is to document instructions for the prevention of exposure in the homes of the patients receiving outpatient chemotherapy. Materials and Methods Subjects and SettingPrior to the study, approval was obtained from the ethics committee of Ishikawa Nursing University (project registration number 561) and the 2 facilities that carried out the chemotherapy for breast cancer.We enrolled 31patients (age: 54.7 ± 10.5) who had been diagnosed with breast cancer more than one month previously, had received one cycle of chemotherapy (FEC, EC, CAF, AC treatment protocol

High risk of hazardous drug exposure in caregivers of pediatric cancer patients

“…They also shared beds with preschool children during chemotherapy. Six hours after the first administration, the concentration of CPM in the urine and saliva of attending caregivers, nurses, doctors, and nursery teachers who worked in the hospital, child‐life specialists, and housekeeping staff members in the ward was measured using modified liquid chromatography/mass spectrometry (LC/MS/MS; Shionogi Analysis Centre Co., Ltd., Osaka, Japan) 6,7 . The current protocol has improved the sensitivity and specificity.…”

“…The environmental contamination in three patients’ rooms is shown in Table 1. We assessed the amount of CPM from wiping and sampling of bed sheets, clothing, and various environmental surfaces in the medical ward using LC/MS/MS, which provided values as the folds of each detection limit 6,7 . Environmental contamination occurred via the body fluid of patients, not drug delivery.…”