Suggestions and tips regarding polymyxin B-immobilized fiber column direct hemoperfusion of neonates with sepsis

Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion for Micro-Preemie Infants: Is Extended Duration Better than Early Start?

“…Since 2011, a PMX-DHP column specialized for neonates with a priming volume of only 8 mL (Toraymyxin ® 01-R; Toray Medical Co., Tokyo, Japan) has been available in Japanese clinical settings. We have been using PMX-DHP for neonatal septic shock and have published several of our experiences [2][3][4][5][6]. Similar to the successful experience described by Mitaka et al [1] , we use PMX-DHP as long as possible, instead of the conventional duration (2 h per session [7]) when there are no adverse events and extracorporeal circulation is possible.…”