Sugars and Gastrointestinal Health

Arnone, Djésia; Chabot, Caroline; Heba, Anne-Charlotte; Kökten, Tunay; Caron, Bénédicte; Hansmannel, Franck; Dreumont, Natacha; Ananthakrishnan, Ashwin N.; Quilliot, Didier; Peyrin–Biroulet, Laurent

doi:10.1016/j.cgh.2021.12.011

Cited by 30 publications

(26 citation statements)

References 128 publications

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“…Therefore, the benefits beyond the anti-hyperglycemic effect would bring advantages to sepsis management. 157 …”

Section: Discussionmentioning

confidence: 99%

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang¹,

Li²,

Wang³

et al. 2022

DDDT

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Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Bacteria translocation and systemic inflammatory response caused by intestinal barrier injury play a significant role in sepsis occurrence and deterioration, while hyperglycemia is linked to adverse outcomes in sepsis. Previous studies have shown that hyperglycemia is an independent risk factor for intestinal barrier injury. Concurrently, increasing evidence has indicated that some anti-hyperglycemic agents not only improve intestinal barrier function but are also beneficial in managing sepsis-induced organ dysfunction. Therefore, we assume that these agents can block or reduce the severity of sepsis by improving intestinal barrier function. Accordingly, we explicated the connection between sepsis, intestinal barrier, and hyperglycemia, overviewed the evidence on improving intestinal barrier function and alleviating sepsis-induced organ dysfunction by anti-hyperglycemic agents (eg, metformin, peroxisome proliferators activated receptor-γ agonists, berberine, and curcumin), and summarized some common characteristics of these agents to provide a new perspective in the adjuvant treatment of sepsis.

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“…Therefore, the benefits beyond the anti-hyperglycemic effect would bring advantages to sepsis management. 157 …”

Section: Discussionmentioning

confidence: 99%

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang¹,

Li²,

Wang³

et al. 2022

DDDT

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“…High consumption of sugar, particularly AS and FS, has been linked to poor overall dietary quality, and excessive energy intake (EI), while contributing to energy imbalance [ 9 , 10 , 11 , 12 ]. Excessive sugar intakes in adults have been implicated in the epidemics of obesity, cardiovascular disorders, type 2 diabetes, non-alcoholic fatty liver diseases, and their downstream cardiometabolic abnormalities such as metabolic syndrome, dyslipidemia and chronic inflammation [ 13 , 14 , 15 ]. It was also reported that both high sugar intakes and hyperglycemia can affect the intestinal barrier, thus heightening gut permeability and leading to profound gut microbiota dysbiosis and disturbances in mucosal immunity, which in turn can increase susceptibility to infections [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Sugar Reduction Initiatives in the Eastern Mediterranean Region: A Systematic Review

et al. 2022

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This systematic review aims to identify and characterize existing national sugar reduction initiatives and strategies in the Eastern Mediterranean Region. For this purpose, a systematic review of published and grey literature was performed. A comprehensive list of search terms in the title/abstract/keyword fields was used to cover the four following concepts (1) sugar, (2) reduction OR intake, (3) policy and (4) EMR countries. A total of 162 peer-reviewed documents were identified, until the 2nd of August 2022. The key characteristics of the identified national strategies/initiatives included the average sugar intake of each country’s population; sugar levels in food products/beverages; implementation strategies (taxation; elimination of subsidies; marketing regulation; reformulation; consumer education; labeling; interventions in public institution settings), as well as monitoring and evaluation of program impact. Twenty-one countries (95%) implemented at least one type of sugar reduction initiatives, the most common of which was consumer education (71%). The implemented fiscal policies included sugar subsidies’ elimination (fourteen countries; 67%) and taxation (thirteen countries 62%). Thirteen countries (62%) have implemented interventions in public institution settings, compared to twelve and ten countries that implemented food product reformulation and marketing regulation initiatives, respectively. Food labeling was the least implemented sugar reduction initiative (nine countries). Monitoring activities were conducted by four countries only and impact evaluations were identified in only Iran and Kingdom of Saudi Arabia (KSA). Further action is needed to ensure that countries of the region strengthen their regulatory capacities and compliance monitoring of sugar reduction policy actions.

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“…The glucose level in the human system exceeding 6.5 mM is a signal of the onset of diabetes [ 2 , 3 ]. In addition, high glucose levels in the human body could lead to malfunction or damage to the vital organs such as the heart, eyes, kidneys, tissues, and blood vessels [ 4 , 5 , 6 ]. Therefore, there is a great need for accurate and timely detection of glucose to protect and save human lives.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Non-Enzymatic Glucose Electrochemical Sensor Based on Electrochemically Synthesized PANI/Bimetallic Oxide Composite

Khan

Marwani

et al. 2022

Polymers

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The development of a sensitive glucose monitoring system is highly important to protect human lives as high blood-glucose level-related diseases continue to rise globally. In this study, a glucose sensor based on polyaniline-bimetallic oxide (PANI-MnBaO2) was reported. PANI-MnBaO2 was electrochemically synthesized on the glassy carbon electrode (GCE) surface. The as-prepared PANI-MnBaO2 was characterized by field emission scanning electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. Glucose sensing on PANI-MnBaO2 is based on the electrocatalytic oxidation of glucose to the glucolactone, which gives oxidation current. The oxidation potential for glucose was 0.83 V, with a limit of detection of 0.06 µM in the linear and in the concentration range of 0.05 µM–1.6 mM. The generated current densities displayed excellent stability in terms of repeatability and reproducibility with fast response. The development of a sensitive glucose sensor as obtained in the current study would ensure human health safety and protection through timely and accurate glucose detection and monitoring.

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Sugars and Gastrointestinal Health

Cited by 30 publications

References 128 publications

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Sugar Reduction Initiatives in the Eastern Mediterranean Region: A Systematic Review

Sensitive Non-Enzymatic Glucose Electrochemical Sensor Based on Electrochemically Synthesized PANI/Bimetallic Oxide Composite

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