Sugar-Sweetened Beverage, Diet Soda, and Nonalcoholic Fatty Liver Disease Over 6 Years: The Framingham Heart Study

Park, William Y.; Yiannakou, Ioanna; Petersen, Julie M.; Hoffmann, Udo; Ma, Jiantao; Long, Michelle T.

doi:10.1016/j.cgh.2021.11.001

Cited by 25 publications

(37 citation statements)

References 33 publications

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“…The Framingham Heart Study (a cohort study of over 14,000 people from three generations that started in 1948) brought attention of sugar as a major factor back into the public eye. This study found that frequent consumers of sugar-sweetened beverages (SSBs) had significantly increased liver fat and dysbiosis (decreased high-density lipoprotein (HDL) and increased triglyceride and cholesterol levels) [ 40 , 74 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Free Sugar on Human Health—A Narrative Review

et al. 2023

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The importance of nutrition in human health has been understood for over a century. However, debate is ongoing regarding the role of added and free sugars in physiological and neurological health. In this narrative review, we have addressed several key issues around this debate and the major health conditions previously associated with sugar. We aim to determine the current evidence regarding the role of free sugars in human health, specifically obesity, diabetes, cardiovascular diseases, cognition, and mood. We also present some predominant theories on mechanisms of action. The findings suggest a negative effect of excessive added sugar consumption on human health and wellbeing. Specific class and source of carbohydrate appears to greatly influence the impact of these macronutrients on health. Further research into individual effects of carbohydrate forms in diverse populations is needed to understand the complex relationship between sugar and health.

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Section: Introductionmentioning

confidence: 99%

The Impact of Free Sugar on Human Health—A Narrative Review

et al. 2023

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“…Of the latter, 57 were removed by exclusion criteria. Therefore, 21 papers were included in the systematic review; these comprised 14 cohort studies [19][20][21][22][23][24][25][26][27][28][29][30][31], five cross-sectional studies [32][33][34][35][36], a crossover study [37], a case-control study [38], and a randomized controlled trial [39].…”

Section: Resultsmentioning

confidence: 99%

“…Most of the participants in the papers under consideration were female [19,22,[24][25][26][27][28][29][30][31][32][33]35,36]. Regarding the health consequences of DS consumers, the following were studied: mental health [20,32,36,38], child neurodevelopment [21], cardiometabolic impact [1,19,29,31], diabetic retinopathy [34], urogenital implications [26,28,37], carcinogenesis [30], fatty liver disease [25,27], autoimmune disease [24], hip fractures [22], and other health impacts [23,33,35,39]. After evaluating each article, 11 records, out of the total analyzed, demonstrated a substantial link between DS and negative health impact [19][20][21][22]26,28,31,32,34,36,38,…”

Section: Resultsmentioning

confidence: 99%

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Artificially Sweetened Beverages Beyond the Metabolic Risks: A Systematic Review of the Literature

Gil¹,

Gil²

2023

Cureus

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We carried out a review of the available literature on the effects that artificially sweetened beverages (ASBs) such as diet soda (DS) have on health, particularly those not related to incident diabetes mellitus, obesity, and metabolic syndrome.A search of scientific articles was carried out using 11 different databases: PubMed, Cochrane, LILACS, MEDLINE Ovid, JAMA Network, IBECS, Cumed, Scopus, SciELO, MEDLINE-EBSCO, and Taylor & Francis Online. Articles published in the last 10 years were considered, considering cross-sectional studies, retrospective or prospective cohort studies, case-control studies, and randomized controlled clinical trials. Only articles in Spanish or English were considered using the MeSH (Medical Subject Heading) and DeCS (Descriptores en Ciencias de la Salud) terms, including "Diet soda," "Health," "Artificial sweetener," "Gaseosa sin azúcar," "Refresco sin azúcar," and "Salud." Additionally, Boolean operators "AND" and "Y" were used.A total of 1,323 articles were obtained in the initial search, of which 21 main ones were selected for review, which included the topic of DS consumption and explored the health consequences that it poses on different organs.The question of whether ASBs such as DS are a preferred substitute is becoming more and more important in terms of public policy due to mounting evidence of the potential negative health effects of their excessive consumption. This systematic review, the first of its kind to our knowledge, sheds light on how excessive DS consumption can affect multiple organ systems, and associations have been made to mental health burden, delays in child neurodevelopment, cardiac remodeling, worsening retinopathy in diabetics, incidental endstage renal disease, non-Hodgkin's lymphoma and multiple myeloma in men, rheumatoid arthritis in women, hip fractures, dental erosion, increases in breath alcohol concentration when used in alcoholic beverages, and accelerated cell aging. Further studies should delve further to understand the pathophysiologic mechanisms of these associations.

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“…Type 2 diabetes and cardiovascular diseases are predisposed to by obesity ( 98 ). Increased body weight can, in fact, cause metabolic changes in cardiomyocytes that switch them from processing fatty acids to sugar, which adds to lipid storage in the pericardium and, as a severe consequence of type 2 diabetes, causes myocardial infarction ( 99 ). Interestingly, inhibition of HDAC11 activity could prevent or ameliorate diabetic cardiomyopathy.…”

Section: Hdac11 In Diabetesmentioning

confidence: 99%

HDAC11, an emerging therapeutic target for metabolic disorders

et al. 2022

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Histone deacetylase 11 (HDAC11) is the only member of the class IV HDAC, and the latest member identified. It is highly expressed in brain, heart, kidney and some other organs, and located in mitochondria, cytoplasm and nuclei, depending on the tissue and cell types. Although studies in HDAC11 total knockout mice suggest its dispensable features for tissue development and life, it participates in diverse pathophysiological processes, such as DNA replication, tumor growth, immune regulation, oxidant stress injury and neurological function of cocaine. Recent studies have shown that HDAC11 is also critically involved in the pathogenesis of some metabolic diseases, including obesity, diabetes and complications of diabetes. In this review, we summarize the recent progress on the role and mechanism of HDAC11 in the regulation of metabolic disorders, with the focus on its regulation on adipogenesis, lipid metabolism, metabolic inflammation, glucose tolerance, immune responses and energy consumption. We also discuss the property and selectivity of HDAC11 inhibitors and their applications in a variety of in vitro and in vivo models of metabolic disorders. Given that pharmacological and genetic inhibition of HDAC11 exerts a beneficial effect on various metabolic disorders, HDAC11 may be a potential therapeutic target to treat chronic metabolic diseases.

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Sugar-Sweetened Beverage, Diet Soda, and Nonalcoholic Fatty Liver Disease Over 6 Years: The Framingham Heart Study

Cited by 25 publications

References 33 publications

The Impact of Free Sugar on Human Health—A Narrative Review

The Impact of Free Sugar on Human Health—A Narrative Review

Artificially Sweetened Beverages Beyond the Metabolic Risks: A Systematic Review of the Literature

HDAC11, an emerging therapeutic target for metabolic disorders

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