Sugar-sweetened beverage consumption and risk of hyperuricemia: a longitudinal analysis of the Health Workers Cohort Study participants in Mexico

Meneses-León, Joacim; León‐Maldonado, Leith; Macías, Nayeli; Torres‐Ibarra, Leticia; Hernández‐López, Rubí; Rivera‐Paredez, Berenice; Flores, Mario; Flores, Yvonne N.; Barrientos‐Gutiérrez, Tonatiuh; Quezada-Sánchez, Amado D.; Velázquez‐Cruz, Rafael; Salmerón, Jorge

doi:10.1093/ajcn/nqaa160

Cited by 14 publications

(11 citation statements)

References 39 publications

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“…We considered masked variance and used the weighting methodology in all analyses [ 33 ]. The survey package of R (version 4.0) was used to account for the complex sampling design [ 34 ]. The general characteristics of the participants were summarized and compared according to hyperuricemia status.…”

Section: Methodsmentioning

confidence: 99%

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

et al. 2022

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Background Diet has long been hypothesized to play an important role in hyperuricemia, and weight gain is a factor that is strongly associated with the rise in serum urate. We aimed to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and to determine whether a weight-loss diet is an effective way to prevent hyperuricemia. Methods This cross-sectional study analysed representative samples of United States (n = 20,081; NHANES 2007–2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyse the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine whether four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product index (LAP), mediated the relationship between nutrient patterns and hyperuricemia. Results PCA revealed three nutrient patterns (including “Low energy diet”, “Lower vitamin A, C, K pattern” and “Vitamin B group”), and only Vitamin B group had a total effect on hyperuricemia. RRR revealed one main nutrient pattern associated with obesity, which was characterized by High fat and low vitamin levels and was significantly associated with hyperuricemia. Mediation analysis showed that obesity mostly or even completely mediated the relationship between nutrient patterns and hyperuricemia, especially traditional obesity indicators, which played a key intermediary effect. The proportions of indirect effects for BMI and WC were as high as 53.34 and 59.69, respectively. Conclusions Our findings suggest that the direct effect of diet on hyperuricemia is weak, and obesity plays a critical mediating role in the relationship between diet and hyperuricemia, which confirms that a weight-loss diet such as a “Low fat and high vitamin diet” may be useful in preventing hyperuricemia.

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Section: Methodsmentioning

confidence: 99%

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

et al. 2022

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“…Spermine showed a 0.38–0.73-fold decrease in the present study and lowered the risk of T2D [ 31 ]. 9-methyluric acid and uric acid were differently affected by acetamiprid and tebuconazole, and they were also reported to be closely related with obesity and T2D [ 32 ]. 7-alpha-hydroxy-17alpha-methyltestosterone was the detected androgen in the serum, and it decreased in the acetamiprid and combined groups but not in the tebuconazole group, indicating that dietary acetamiprid exposure also affected the reproductive endocrine system.…”

Section: Resultsmentioning

confidence: 99%

Gut Flora-Mediated Metabolic Health, the Risk Produced by Dietary Exposure to Acetamiprid and Tebuconazole

Jingkun

Zhao

et al. 2021

Foods

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The low-level and long-term exposure of pesticides was found to induce metabolic syndrome to mice. Metabolic pathways and mechanisms were investigated by detecting gut flora with metabolites, host circulation, and their interrelations. Results showed that the abundances of flora species and their metabolism were altered, consequently leading to metabolic disorders. A correlation analysis between gut flora and their metabolic profiling further explained these changes and associations. The metabolic profiling of host circulation was also performed to characterize metabolic disorders. The associations of host circulation with gut flora were established via their significantly different metabolites. Alterations to the liver metabolism clarified potential pathways and mechanisms for the disorders. Metabolic disorders were evidently released by dietary and micro-ecological intervention, directly proving that gut flora comprise a vital medium in metabolic health risk caused by pesticide exposure. This work supplied theoretical bases and intervention approaches to body metabolic problems caused by pesticide exposure mediated by gut flora.

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“…We considered masked variance and used the weighting methodology in all analyses [33]. Survey package of R (version 4.0) was used to account for the complex sampling design [34]. General characteristics of participants were summarized and compared according to hyperuricemia status.…”

Section: Discussionmentioning

confidence: 99%

Association between Nutrient Patterns and Hyperuricemia: Mediation Analysis Involving Obesity Indicators for NHANES study

Wang

Chen

Zhao

et al. 2022

Preprint

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Background: Diet had long been hypothesized to play an important role in hyperuricemia and weight gain was the stronger factor associated with the rise in serum urate. We aim to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and further determine whether the weight-loss diet is an effective way to prevent hyperuricemia. Methods: This cross-sectional study analyzed representative samples of the United States (n=20081; NHANES 2007-2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyze the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine if four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product Index (LAP), mediated nutrient patterns and hyperuricemia relationship. Results: PCA revealed three nutrient patterns (including “low energy diet”, “lower vitamin A, C, K pattern” and “vitamin B group”) and only vitamin B group had a total effect on hyperuricemia. RRR resulted in one main nutrient pattern associated with obesity, which is characterized by high fat and low vitamin levels and was significantly associated with hyperuricemia. Mediation analysis showed that obesity mostly or even completely mediated the relationship between nutrient patterns and hyperuricemia, especially traditional obesity indicators play a key intermediary effect. Proportion of indirect effect for BMI and WC were as high as 53.34 and 59.69, respectively.Conclusions: Our findings suggest that the direct effect of diet on hyperuricemia is weak, and obesity plays a critical mediated role in the pathway between diet and hyperuricemia, which confirms that weight-loss diet may be useful in preventing hyperuricemia.

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Sugar-sweetened beverage consumption and risk of hyperuricemia: a longitudinal analysis of the Health Workers Cohort Study participants in Mexico

Abstract: ABSTRACT Background The elevated consumption of sugar-sweetened beverages (SSBs) in Mexico is an important public health concern. However, the association between SSB consumption and hyperuricemia has been scarcely studied and not well documented. Objectives To pr… Show more

Cited by 14 publications

References 39 publications

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Gut Flora-Mediated Metabolic Health, the Risk Produced by Dietary Exposure to Acetamiprid and Tebuconazole

Association between Nutrient Patterns and Hyperuricemia: Mediation Analysis Involving Obesity Indicators for NHANES study

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