Sugar reduction in beverages: Current trends and new perspectives from sensory and health viewpoints

Sweet Taste Receptors and Associated Sweet Peptides: Insights into Structure and Function

“…62 Both alitame and advantame are synthetic dipeptide derivatives with good heat stability and high sweetness potency, which are 7000− 13 000 times sweeter than sucrose. 14,65 However, alitame has a slightly sulfuric taste as a result of the presence of sulfur atoms in the molecular structure. 14 16S rRNA sequencing and gas chromatography−mass spectrometry (GC−MS) metabolomics was employed to investigate the effects of neotame on the gut microbiome and the fecal metabolome of male CD-1 mice.…”

“…Therefore, neotame is widely used in various food products, such as dairy products, baked foods, beverages, and alcoholic products . Both alitame and advantame are synthetic dipeptide derivatives with good heat stability and high sweetness potency, which are 7000–13 000 times sweeter than sucrose. , However, alitame has a slightly sulfuric taste as a result of the presence of sulfur atoms in the molecular structure …”

“…14,65 However, alitame has a slightly sulfuric taste as a result of the presence of sulfur atoms in the molecular structure. 14 16S rRNA sequencing and gas chromatography−mass spectrometry (GC−MS) metabolomics was employed to investigate the effects of neotame on the gut microbiome and the fecal metabolome of male CD-1 mice. 66 Water (control group) or neotame-containing water (neotametreated group) was administered to the mice by gavage for 4 weeks.…”

“…While some studies suggest a potential association between saccharin consumption and bladder cancer, significant associations with other types of cancer have not been systematically observed in case-control investigations nor meta-analyses of prospective cohort studies. , In addition to the controversy of NSS and cancer, the impact of NSS on human metabolism has received increasing attention. The health concerns associated with effects on metabolism include the increased risk of overweight and obesity as a result of the compensatory increase in food intake, type 2 diabetes, CVDs, and metabolic syndrome . NSS may disrupt the gut microbiota, leading to a decrease in the population of gut microbes correlated with both obesity and insulin resistance …”

“…The health concerns associated with effects on metabolism include the increased risk of overweight and obesity as a result of the compensatory increase in food intake, type 2 diabetes, CVDs, and metabolic syndrome. 14 NSS may disrupt the gut microbiota, leading to a decrease in the population of gut microbes correlated with both obesity and insulin resistance. 15 Sweet peptides, a category of peptides exhibiting a natural sweet taste procured from food sources or synthesized through amino acid synthesis, have gained contemporary interest.…”