Sugar Micro Needles as Transdermic Drug Delivery System

Miyano, Takeshi; Tobinaga, Yoshikazu; Kanno, Takahiro; Matsuzaki, Yasushi; Takeda, Hitoshi; Wakui, Makoto; Hanada, Katsumi

doi:10.1007/s10544-005-3024-7

Cited by 210 publications

(109 citation statements)

References 11 publications

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“…Based on their structures and materials, microneedles may be classified into three categories: inorganic solid microneedles, 4,5 hollow microneedles, 6,7 and polymer microneedles. [8][9][10] Among these microneedle technologies, polymer microneedles are the most feasible due to their uncomplicated fabrication and low cost.…”

Section: Introductionmentioning

confidence: 99%

A scalable fabrication process of polymer microneedles

Yang¹,

Feng²,

Zhang³

et al. 2012

IJN

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While polymer microneedles may easily be fabricated by casting a solution in a mold, either centrifugation or vacuumizing is needed to pull the viscous polymer solution into the microholes of the mold. We report a novel process to fabricate polymer microneedles with a one-sided vacuum using a ceramic mold that is breathable but water impermeable. A polymer solution containing polyvinyl alcohol and polysaccharide was cast in a ceramic mold and then pulled into the microholes by a vacuum applied to the opposite side of the mold. After cross-linking and solidification through freeze-thawing, the microneedle patch was detached from the mold and transferred with a specially designed instrument for the drying process, during which the patch shrank evenly to form an array of regular and uniform needles without deformation. Moreover, the shrinkage of the patches helped to reduce the needles' size to ease microfabrication of the male mold. The dried microneedle patches were finally punched to the desired sizes to achieve various properties, including sufficient strength to penetrate skin, microneedles-absorbed water-swelling ratios, and drug-release kinetics. The results showed that the microneedles were strong enough to penetrate pigskin and that their performance was satisfactory in terms of swelling and drug release.

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Section: Introductionmentioning

confidence: 99%

A scalable fabrication process of polymer microneedles

Yang¹,

Feng²,

Zhang³

et al. 2012

IJN

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“…This maximises the drug volume capacity of microneedles however their fabrication is more difficult [14] (See Fig. 1(c)).…”

Section: B Solid Degradable Microneedlesmentioning

confidence: 99%

Current Trends in MEMS Drug Delivery Techniques

Ullah¹,

Kaw²,

Rasool³

et al. 2017

IJET

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Abstract-The popularisation of the microsystems has paved a way for the evolution of a new class of controlled drug delivery devices which allow tailored delivery of drugs. Additionally, these drug delivery systems enhance efficiency and patient consent. Developing better drug delivery methods is the prime target of the pharmaceutical companies worldwide. The process of drug delivery is as essential as the drug's activity in deciding its effectiveness. These drug delivery systems do not simply release the drug but disseminate the drug in a peculiar manner in accordance to which it has been engineered. Although in their initial stages, the microelectromechanical systems (MEMS) demonstrate the immense potential for conquering the various challenges that are faced by the present drug delivery techniques. Microneedles, micropumps, microvalves, and implantable drug delivery systems have been developed using microfabrication techniques. Several microdevices have been engineered such that they deliver multiple drugs with different dosages in series or parallel which provide several advantages such as extension in the variety of the desirable compounds and precise dosing. Transdermal drug delivery through microneedles enables enhanced permeation through skin layers into the body. Multilayer patch systems lead to an excellent approach in the oral drug delivery. This review examines various MEMS drug delivery techniques along with their diverse benefits.

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“…They are generally classified into ''solid'' and ''hollow'' MNs (Al-Qallaf et al, 2009;Olatunji & Das, 2010;Olatunji et al, 2012;Han & Das, 2013;Zhang et al, 2013a,b). The solid MNs are able to penetrate the human skin to make holes (McAllister et al, 2003;Davis et al, 2004;Kalluri & Banga, 2011) as well as deliver drugs/genes that are coated (Cormier et al, 2004) or encapsulated (Miyano et al, 2005). The MN holes can also be used by the biolistic system for the delivery of the microparticles.…”

Section: Introductionmentioning

confidence: 99%

Microneedle-assisted microparticle delivery by gene guns: experiments and modeling on the effects of particle characteristics

2014

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Microneedles (MNs) have been shown to enhance the penetration depths of microparticles delivered by gene gun. This study aims to investigate the penetration of model microparticle materials, namely, tungsten (51 mm diameter) and stainless steel (18 and 30 mm diameters) into a skin mimicking agarose gel to determine the effects of particle characteristics (mainly particle size). A number of experiments have been processed to analyze the passage percentage and the penetration depth of these microparticles in relation to the operating pressures and MN lengths. A comparison between the stainless steel and tungsten microparticles has been discussed, e.g. passage percentage, penetration depth. The passage percentage of tungsten microparticles is found to be less than the stainless steel. It is worth mentioning that the tungsten microparticles present unfavourable results which show that they cannot penetrate into the skin mimicking agarose gel without the help of MN due to insufficient momentum due to the smaller particle size. This condition does not occur for stainless steel microparticles. In order to further understand the penetration of the microparticles, a mathematical model has been built based on the experimental set up. The penetration depth of the microparticles is analyzed in relation to the size, operating pressure and MN length for conditions that cannot be obtained in the experiments. In addition, the penetration depth difference between stainless steel and tungsten microparticles is studied using the developed model to further understand the effect of an increased particle density and size on the penetration depth.

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Sugar Micro Needles as Transdermic Drug Delivery System

Cited by 210 publications

References 11 publications

A scalable fabrication process of polymer microneedles

A scalable fabrication process of polymer microneedles

Current Trends in MEMS Drug Delivery Techniques

Microneedle-assisted microparticle delivery by gene guns: experiments and modeling on the effects of particle characteristics

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