Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation

Yoshida, Yukiko; Takahashi, Tsuyoshi; Ishii, Nozomi; Matsuo, Ichiro; Takahashi, Satoshi; Inoue, Haruka; Endo, Akinori; Tsuchiya, Hikaru; Okada, Meari; Ando, Chikara; Suzuki, Takehiro; Dohmae, Naoshi; Saeki, Yasushi; Tanaka, Keiji; Suzuki, Tadashi

doi:10.1016/j.molcel.2024.07.013

Molecular Cell

2024

DOI: 10.1016/j.molcel.2024.07.013

|View full text |Cite

Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation

Yukiko Yoshida,

Tsuyoshi Takahashi,

Nozomi Ishii

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Structural basis of sugar recognition by SCF^FBS2 ubiquitin ligase involved in NGLY1 deficiency

Satoh,

Yagi‐Utsumi,

Ishii

et al. 2024

FEBS Letters

View full text Add to dashboard Cite

The cytosolic peptide:N‐glycanase (PNGase) is involved in the quality control of N‐glycoproteins via the endoplasmic reticulum‐associated degradation (ERAD) pathway. Mutations in the gene encoding cytosolic PNGase (NGLY1 in humans) cause NGLY1 deficiency. Recent findings indicate that the F‐box protein FBS2 of the SCFFBS2 ubiquitin ligase complex can be a promising drug target for NGLY1 deficiency. Here, we determined the crystal structure of bovine FBS2 complexed with the adaptor protein SKP1 and a sugar ligand, Man3GlcNAc2, which corresponds to the core pentasaccharide of N‐glycan. Our crystallographic data together with NMR data revealed the structural basis of disparate sugar‐binding specificities in homologous FBS proteins and identified a potential druggable pocket for in silico docking studies. Our results provide a potential basis for the development of selective inhibitors against FBS2 in NGLY1 deficiency.

show abstract

Structural basis of sugar recognition by SCF^FBS2 ubiquitin ligase involved in NGLY1 deficiency

Satoh,

Yagi‐Utsumi,

Ishii

et al. 2024

FEBS Letters

View full text Add to dashboard Cite

show abstract

Ubiquitin gets sweet: Sugar-mediated ubiquitination regulates Nrf1 function

Mody,

Woo

2024

Molecular Cell

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation

Cited by 2 publications

References 65 publications

Structural basis of sugar recognition by SCF^FBS2 ubiquitin ligase involved in NGLY1 deficiency

Structural basis of sugar recognition by SCF^FBS2 ubiquitin ligase involved in NGLY1 deficiency

Ubiquitin gets sweet: Sugar-mediated ubiquitination regulates Nrf1 function

Contact Info

Product

Resources

About

Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation

Cited by 2 publications

References 65 publications

Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency

Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency

Ubiquitin gets sweet: Sugar-mediated ubiquitination regulates Nrf1 function

Contact Info

Product

Resources

About

Structural basis of sugar recognition by SCF^FBS2 ubiquitin ligase involved in NGLY1 deficiency

Structural basis of sugar recognition by SCF^FBS2 ubiquitin ligase involved in NGLY1 deficiency