Sugar Interaction With Alkali Metal Ions. Synthesis and Vibrational Spectra of Crystalline Sucrose and Its Sodium Halide Adducts

Tajmir, Heidar-Ali; Riahi,

doi:10.1080/00958978608079773

Cited by 16 publications

(1 citation statement)

References 13 publications

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“…Studies on metal-gene [16][17][18], metal-sugar [19][20][21][22][23], and metal-lipid [24,25] complexes and interactions have also attracted much attention, and the terms "metallogenomics" [26] and "metalloglycomics" [27] have been used and the term "metallolipidomics" may be used to cover the different overlap areas between metals with genes, sugars, or lipids as shown in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Metallomics, elementomics, and analytical techniques

Chen

et al. 2008

Pure and Applied Chemistry

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Metallomics is an emerging and promising research field which has attracted more and more attention. However, the term itself might be restrictive. Therefore, the term "elementomics" is suggested to encompass the study of nonmetals as well. In this paper, the application of state-of-the-art analytical techniques with the capabilities of high-throughput quantification, distribution, speciation, identification, and structural characterization for metallomics and elementomics is critically reviewed. High-throughput quantification of multielements can be achieved by inductively coupled plasma-mass spectrometry (ICP-MS) and neutron activation analysis (NAA). High-throughput multielement distribution mapping can be performed by fluorescence-detecting techniques such as synchrotron radiation X-ray fluorescence (SR-XRF), XRF tomography, energy-dispersive X-ray (EDX), proton-induced Xray emission (PIXE), laser ablation (LA)-ICP-MS, and ion-detecting-based, secondary-ion mass spectrometry (SIMS), while Fourier transform-infrared (FT-IR) and Raman microspectroscopy are excellent tools for molecular mapping. All the techniques for metallome and elementome structural characterization are generally low-throughput, such as X-ray absorption spectroscopy (XAS), NMR, and small-angle X-ray spectroscopy (SAXS). If automation of arraying small samples, rapid data collection of multiple low-volume and -concentration samples together with data reduction and analysis are developed, high-throughput techniques will be available and in fact have partially been achieved.

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Section: Introductionmentioning

confidence: 99%

Metallomics, elementomics, and analytical techniques

Chen

et al. 2008

Pure and Applied Chemistry

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Assembling Sugars and Metals: Novel Architectures and Reactivities in Transition Metal Chemistry

Piarulli¹,

Floriani²

1996

Progress in Inorganic Chemistry

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ESI⁺MS/MS confirmation of canine ivermectin toxicity

et al. 2008

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Ivermectin is a semisynthetic macrocyclic lactone anthelmintic of the avermectin family derived from Streptomyces fermentation products. Avermectins are used as antiparasitic agents in domestic animals; although considered relatively safe, one must consider animal species, breed, weight, and age in dosage determinations.In January 2006, two canines were presented to the UK Livestock Disease Diagnostic Center after dying from suspected ivermectin overdoses [30-50 mg/kg body weight]. To confirm this clinical diagnosis we developed a rapid, sensitive semiquantitative ElectroSpray Ionization-Mass Spectrometry (ESI/MS) method for ivermectin in canine tissue samples. Pharmaceutical ivermectin contains two ivermectins differing by a single methyl group, and each compound forms interpretation-confounding adducts with tissue Na(+) and K(+) ions. We now report that ivermectin administration was clearly confirmed by comparison with standard and dosage forms of ivermectin, and simple proportionalities based on mass spectral intensity of respective molecular ions allowed semiquantitative estimates of injection site tissue concentrations of 20 and 40 microg/g tissue (wet weight) in these animals, consistent with the history of ivermectin administration and the clinical signs observed.There is a distinct need for both rapid detection and confirmation of toxic exposures in veterinary diagnostics, whether for interpretation of clinical cases antemortem or for forensic reasons postmortem. It is vital that interpreters of analytical results have appropriate guidance in the scientific literature and elsewhere so as to enable clear-cut answers. The method presented here is suitable for routine diagnostic work in that it allows rapid extraction of ivermectin from tissue samples, avoids the need for high-performance liquid chromatography and allows ready interpretation of the multiple ivermectin species seen by ESI(+) MS/MS in samples originating from veterinary dosage forms.

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Sugar Interaction With Alkali Metal Ions. Synthesis and Vibrational Spectra of Crystalline Sucrose and Its Sodium Halide Adducts

Cited by 16 publications

References 13 publications

Metallomics, elementomics, and analytical techniques

Metallomics, elementomics, and analytical techniques

Assembling Sugars and Metals: Novel Architectures and Reactivities in Transition Metal Chemistry

ESI⁺MS/MS confirmation of canine ivermectin toxicity

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Sugar Interaction With Alkali Metal Ions. Synthesis and Vibrational Spectra of Crystalline Sucrose and Its Sodium Halide Adducts

Cited by 16 publications

References 13 publications

Metallomics, elementomics, and analytical techniques

Metallomics, elementomics, and analytical techniques

Assembling Sugars and Metals: Novel Architectures and Reactivities in Transition Metal Chemistry

ESI+MS/MS confirmation of canine ivermectin toxicity

Contact Info

Product

Resources

About

ESI⁺MS/MS confirmation of canine ivermectin toxicity