Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of <i>Caenorhabditis elegans</i>

Papaevgeniou, Nikoletta; Hoehn, Annika; Tur, Josep A.; Klotz, Lars‐Oliver; Grune, Tilman; Chondrogianni, Niki

doi:10.1080/10715762.2019.1661403

Cited by 14 publications

(7 citation statements)

References 54 publications

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“…As 1D) [41]. Further, a recent study demonstrated that treatment with sugar-derived AGE-modified Bovine Serum Albumin (BSA) accelerated the pharyngeal pumping rate [42]. In our study, we demonstrate that endogenous production and accumulation of AGEs via genetic mutation increase feeding and adversely affect lifespan.…”

Section: Discussionsupporting

confidence: 56%

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

Shanmugam

Chaudhuri

Sellegounder

et al. 2022

Preprint

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The Maillard reaction, a chemical reaction between amino acids and sugars, is exploited to produce flavorful food almost everywhere, from the baking industry to our everyday life. However, the Maillard reaction also takes place in all cells, from prokaryotes to eukaryotes, leading to the formation of Advanced Glycation End-products (AGEs). AGEs are a heterogeneous group of compounds resulting from the irreversible reaction between biomolecules and α- dicarbonyls (α-DCs), including methylglyoxal (MGO), an unavoidable byproduct of anaerobic glycolysis and lipid peroxidation. We previously demonstrated that Caenorhabditis elegans mutants lacking the glod-4 glyoxalase enzyme displayed enhanced accumulation of α-DCs, reduced lifespan, increased neuronal damage, and touch hypersensitivity. Here, we demonstrate that glod-4 mutation increased food intake and identify that MGO-derived hydroimidazolone, MG-H1, is a mediator of the observed increase in food intake. RNA-seq analysis in glod-4 knockdown worms identified upregulation of several neurotransmitters and feeding genes. Suppressor screening of the overfeeding phenotype identified the tdc-1-tyramine-tyra-2/ser-2 signaling as an essential pathway mediating AGEs (MG-H1) induced feeding in glod-4 mutants. We also identified the elt-3 GATA transcription factor as an essential upstream factor for increased feeding upon accumulation of AGEs by partially regulating the expression of tdc-1 and tyra-2 genes. Further, the lack of either tdc-1 or tyra-2/ser-2 receptors suppresses the reduced lifespan and rescues neuronal damage observed in glod-4 mutants. Thus, in C. elegans, we identified an elt-3 regulated tyramine-dependent pathway mediating the toxic effects of MGO and associated AGEs. Understanding this signaling pathway is essential to modulate hedonistic overfeeding behavior observed in modern AGEs rich diets.

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Section: Discussionsupporting

confidence: 56%

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

Shanmugam

Chaudhuri

Sellegounder

et al. 2022

Preprint

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“…In contrast, the pharyngeal pumping rate was found increased in the presence of DBTO. Although we did not monitor the pharyngeal pumping rate throughout the lifespan of the animals, several compounds that positively affect healthspan have been shown to induce this rate already from day 1 of adulthood [ 42 , 43 ]. Therefore, this DBTO-dependent increase in the pumping rate could also predict a better healthspan during the progression of aging but more experimentation is needed.…”

Section: Resultsmentioning

confidence: 99%

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator

et al. 2022

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“…Maillard reaction products exhibit strong antioxidant activity and increase the lifespan of C . elegans (Papaevgeniou et al, 2019 ; Yokoyama et al, 2021 ). Since KL has high reactivity in the Maillard reaction, its Maillard reaction products may affect the longevity in C .…”

Section: Discussionmentioning

confidence: 99%

Effects of the dipeptides comprising leucine and lysine on lifespan and age‐related stress in Caenorhabditis elegans

Yokoyama

Setoyama

Jia

et al. 2023

Food Science & Nutrition

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The aging process is affected by various stressors. An increase in oxidative stress is related to the impairment of physiological functions and enhancement of glycative stress. Food‐derived bioactive peptides have various physiological functions, including antioxidant activities. Dipeptides comprising Leu and Lys (LK and KL, respectively) have been isolated from foods; however, their physiological properties remain unclear. In this study, we investigated the antioxidant/antiglycation activity of dipeptides and their antiaging effects using Caenorhabditis elegans (C. elegans). Both dipeptides showed antioxidant activities against several reactive oxygen species (ROS) in vitro. In particular, the scavenging activity of LK against superoxide radicals was higher than KL did. Moreover, dipeptides suppressed advanced glycation end products (AGEs) formation in the BSA–glucose model. In the lifespan assays using wild‐type C. elegans, both LK and KL significantly prolonged the mean lifespan by 20.9% and 11.7%, respectively. In addition, LK decreased intracellular ROS and superoxide radical levels in C. elegans. Blue autofluorescence, an indicator of glycation in C. elegans with age, was also suppressed by LK. These results suggest that dipeptides, notably LK, show an antiaging effect by suppressing oxidative and glycative stress. Our findings suggest that such dipeptides can be used as a novel functional food ingredient. Food‐derived dipeptide Leu–Lys (LK) and Lys–Leu (KL) exert antioxidant and antiglycation activity in vitro. Treatment with LK prolonged the mean lifespan and maximum lifespan of C. elegans more than that of KL. Intracellular ROS and blue autofluorescence levels (indicator of aging) were suppressed by LK.

show abstract

Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of Caenorhabditis elegans

Cited by 14 publications

References 54 publications

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator

Effects of the dipeptides comprising leucine and lysine on lifespan and age‐related stress in Caenorhabditis elegans

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