Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study

Francini-Pesenti, Francesco; Brocadello, Filippo; Beltramolli, Dario; Nardi, Mariateresa; Caregaro, L.

doi:10.1016/j.ctim.2007.08.003

Cited by 28 publications

(34 citation statements)

References 30 publications

(35 reference statements)

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“…The data presented for the NEP group are consistent with recent studies showing the lack of policosanol effect in modifying total or LDLcholesterol (Greyling et al, 2006;Berthold et al, 2006;Dulin et al, 2006;Kassis and Jones, 2006;Francini-Pesenti et al, 2008a;Francini-Pesenti et al, 2008b;Kassis et al, 2007;Murphy et al, 2008), considering that the supplementation of rats with 100 mg/kg body weight of NEP, the same form of administration in previously reported investigations, did not alter lipid concentrations when compared to the control group. Nevertheless, the OAEP group exhibited significantly lower concentrations of plasmatic LDL-cholesterol, as the primary endpoint, and total cholesterol, as the secondary endpoint, in normocholesterolemic rats after 5 weeks of treatment.…”

Section: The Oleic Acid Esterification Of Policosanol Increases Its Bsupporting

confidence: 80%

“…However, recent clinical trials failed to show significant effects. In fact, no changes in lipid variables in subjects receiving policosanol were reported (Greyling et al, 2006;Berthold et al, 2006;Dulin et al, 2006;Kassis and Jones, 2006) and neither primary hypercholesterolemic subjects (Francini-Pesenti et al, 2008a) nor diet-resistant hypercholesterolemic patients (Francini-Pesenti et al, 2008b) were affected by policosanol treatment for 8 weeks.…”

Section: Introductionmentioning

confidence: 99%

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The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats

Haim¹,

Valenzuela²,

Brañes³

et al. 2012

Grasas y Aceites

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(DH, and AV); d Naturalis S.A., Santiago, Chile (MCB, and MF) *Corresponding author: dnhaim@miuandes.cl RESUMEN La esterificación de ácido oleico en policosanoles aumenta su biodisponibilidad y el efecto hipocolesterolémico en ratasLos Policosanoles están formados por una mezcla de alcoholes alifáticos de cadena larga y se obtienen de las ceras de la caña de azúcar. Más de cincuenta estudios indican que los policosanoles reducen el colesterol sérico, mientras que otros no logran reproducir este efecto. El objetivo de esta investigación fue evaluar la biodisponibilidad de policosanoles esterificados y no esterificados (NEP), en relación con sus efectos hipocolesterolémicos. Para ello, a ratas Sprague Dawley se les administró una dosis oral diaria de 100 mg kg -1 de NEP, 117 mg kg -1 de policosanoles esterificados con ácido butírico (BAEP), ó 164 mg kg -1 de policosanoles esterificados con ácido oleico (OAEP). La absorción de los policosanoles se evaluó en el plasma entre 0 y 3 horas después de la ingestión. Para evaluar los cambios en el colesterol total, colesterol-LDL, colesterol-HDL y triglicéridos en el plasma y en la fosforilación de la hígado 3-hidroxi-3-metilglutaril coenzima A reductasa (HMG-CoA red), la ingesta de las ratas fue suplementada con policosanoles no esterificados o esterificados durante 5 semanas. Los resultados indicaron que la absorción de los policosanoles fue significativamente mayor en las ratas tratadas con los OAEP que en las sometidas a los NEP o las que se les administró BAEP. Los OAEP redujeron significativamente el colesterol plasmático total y el colesterol-LDL de las ratas, además de aumentar 5.6 veces (P < 0,05) sobre los valores control, en el contenido hepático de la HMG-CoA fosforilada red. En conclusión, la esterificación de policosanoles con ácido oleico aumenta la biodisponibilidad de los policosanoles, y mejora significativamente el perfil de lípidos séricos en ratas normocolesterolémicos en asociación con la inactivación de la colesterogénesis control HMG-CoA red. PALABRAS-CLAVE: Absorción de Policosanoles -Biodisponibilidad -Efecto reductor de colesterol -Octacosanol -Policosanol -Triacontanol -Ratas. SUMMARY The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in ratsPolicosanol comprises a mixture of long-chain aliphatic alcohols from sugarcane wax. More than 50 studies indicate that policosanol decreases serum cholesterol, while others failed to reproduce this effect. The objective of this investigation was to assess the bioavailability of esterified policosanol and non-esterified policosanol (NEP), in relation to their hypocholesterolemic effects. Sprague Dawley rats were given a daily oral dose of 100 mg/kg of NEP, 117 mg kg -1 of butyric acid esterified policosanol (BAEP), or 164 mg kg -1 of oleic acid esterified policosanol (OAEP). Policosanol absorption was evaluated in plasma between 0 and 3 hours after ingestion. To assess changes in total cholesterol, LDL-cholesterol, HDLcholesterol and triacylglycerols in ...

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Section: The Oleic Acid Esterification Of Policosanol Increases Its Bsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats

Haim¹,

Valenzuela²,

Brañes³

et al. 2012

Grasas y Aceites

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“…The same result was observed by Guardamagna et al using a combination of RYR (200 mg) and policosanols (10 mg) and by Marazzi et al [38], using a combination of berberine (500 mg), RYR (200 mg) and policosanols (10 mg) in elderly hypercholesterolemic patients. More recent studies have led to less conclusive results regarding the effectiveness of policosanols [39][40][41]. The effects of policosanols also remain very controversial.…”

Section: Discussionmentioning

confidence: 93%

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

et al. 2012

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“…So inhibiting cholesterol biosynthesis and enhancing low-density lipoprotein (LDL) decatabolism (Menendez, 1994). Similarly, PD improves protection of lipoproteins against lipid peroxidation, both in the lipid and the protein moieties (Menendez, 1999).However, Franci-Pesenti et al (Francini-Pesenti, 2008) have reported that the mechanisms by which PC improves plasma lipid profile are unclear, and there is a continuing debate about the exact effect of PC. Nevertheless, PC was successful worldwide, and it is sold as a lipid-lowering supplement in more than 40 countries (Cherif, 2010b).…”

Section: Beneficial Effects Of Policosanolmentioning

confidence: 99%

Phytochemicals Components as Bioactive Foods

Chérif¹

2012

Bioactive Compounds in Phytomedicine

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Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study

Cited by 28 publications

References 30 publications

The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats

The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

Phytochemicals Components as Bioactive Foods

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