Sugar

Schiweck, H.; Clarke, M. A.; Pollach, G.

doi:10.1002/14356007.a25_345.pub2

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…In general, trimethylglycine betaine is a natural byproduct of beet sugar. This amino acid derivative is most applicable in food supplements for animals, personal care ingredients, treatment of nonalcoholic steatohepatitis, and enzyme stabilizers. − Nowadays, green technology is rapidly infusing new solvent systems to replace the common volatile and hazardous organic solvent systems. Over the past decade, ionic liquids have attracted researchers due to some distinct properties, such as water miscibility, thermal stability, low combustibility, and good solvating properties for a range of polar and nonpolar compounds. , Numerous articles based on the use of ionic liquids as solvents cum catalysts are available in the literature. − Ionic liquids find applications in solvent extraction, , biocatalytic processes, and also in electrochemical processes .…”

Section: Introductionmentioning

confidence: 99%

Trimethylglycine-Betaine-Based-Catalyst-Promoted Novel and Ecocompatible Pseudo-Four-Component Reaction for Regioselective Synthesis of Functionalized 6,8-Dihydro-1′H,5H-spiro[[1,3]dioxolo[4,5-g]quinoline-7,5′-pyrimidine]-2′,4′,6′(3′H)-trione Derivatives

Patel

2019

ACS Sustainable Chem. Eng.

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Nowadays, synthesis of novel nitrogen-bearing heterocyclic scaffolds is a challenging and also demanding task. In our present work, we demonstrate a novel one-pot pseudofour-component reaction of 3,4-methylenedioxyaniline, N,Ndimethylbarbituric acid, and aryl/heteroaryl aldehydes for the regioselective construction of functionalized 6,8-dihydro-1′H,5H-spiro [[1,3]dioxolo[4,5-g]quinoline-7,5′-pyrimidine]-2′,4′,6′(3′H)-trione scaffolds using a trimethylglycine-betainebased sustainable catalyst. The title derivatives are achieved through the formation of three new C−C bonds and one C− N bond, and two asymmetric carbon centers are generated in the final motif. The present protocol works efficiently, tolerates different substituents present in reactants, has a simple operational procedure, provides excellent reaction yield in a short time, uses a recyclable catalyst, and results in up to 99.7% purity (HPLC) for the synthesized compounds, with high diastereoselectivity (d.r. > 50:1 (syn/anti)), excellent atom economy, reaction mass efficiency, and effective mass yield.

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Section: Introductionmentioning

confidence: 99%

Trimethylglycine-Betaine-Based-Catalyst-Promoted Novel and Ecocompatible Pseudo-Four-Component Reaction for Regioselective Synthesis of Functionalized 6,8-Dihydro-1′H,5H-spiro[[1,3]dioxolo[4,5-g]quinoline-7,5′-pyrimidine]-2′,4′,6′(3′H)-trione Derivatives

Patel

2019

ACS Sustainable Chem. Eng.

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“…The rationale for the use of the yeast strain, S. boulardii , is to restore the capacity of the human gut to digest sucrose. S. boulardii, given as a nutritional supplement while miglustat is co-administered, provides an exogenous sucrase (invertase) that hydrolyzes sucrose through a different mechanism from that of human sucrase [ 17 ]. Co-administration of S. boulardii would have the advantage of decreasing the need for dietary restriction or low-carbohydrate diets, and improve GI tolerability, comfort and compliance with miglustat therapy.…”

Section: Discussionmentioning

confidence: 99%

“…GI disturbances during miglustat treatment are thought to arise from the inhibition of intestinal disaccharidases, mainly sucrase isomaltase [ 11 , 13 – 15 ]. Miglustat (1,5 (butylimino)-1,5-dideoxy-D-glucitol) – a glucose analog – inhibits the human disaccharidase, sucrase, which cleaves sucrose at the O-C (glucose) bond [ 14 , 16 , 17 ]. Furthermore, relatively little inhibition of intestinal lactase, and down-regulation of sucrase expression in gastrointestinal epithelium have been observed [ 11 , 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…There is anecdotal evidence of favorable effects from the co-administration of miglustat with Saccharomyces boulardii probiotics (Burlina A, personal communication). S. boulardii produces a high amount of invertase [ 27 , 28 ], and may be a good candidate because yeast-secreted sucrase cleaves sucrose at the O-C (fructose) bond [ 17 ] and is not expected to be inhibited by miglustat, which is a glucose analog. The probiotic formulation, Florastor® (syn.…”

Section: Introductionmentioning

confidence: 99%

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A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat

Remeňová

Morand

Amato

et al. 2015

Orphanet J Rare Dis

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BackgroundGastrointestinal (GI) disturbances such as diarrhea and flatulence are the most frequent adverse effects associated with miglustat therapy in type 1 Gaucher disease (GD1) and Niemann-Pick disease type C (NP-C), and the most common recorded reason for stopping treatment during clinical trials and in clinical practice settings. Miglustat-related GI disturbances are thought to arise from the inhibition of intestinal disaccharidases, mainly sucrase isomaltase. We report the effects of a co-administered dietary probiotic, S. boulardii, on the GI tolerability of miglustat in healthy adult subjects.MethodsIn a double-blind, placebo-controlled, two-period, two-treatment cross-over trial, healthy adult male and female subjects were randomly allocated to treatment sequences, A–B and B–A (treatment A - miglustat 100 mg t.i.d. + placebo; treatment B - miglustat 100 mg t.i.d. + S. boulardii [500 mg, b.i.d.]). GI tolerability data were collected in patient diaries. The primary endpoint was the total number of ‘diarrhea days’ (≥3 loose stools within a 24-h period meeting Bristol Stool Scores [BSS] 6–7) based on WHO criteria. Secondary endpoints comprised numerous other diarrhea and GI tolerability indices.ResultsTwenty-one subjects received randomized therapy in each treatment sequence (total N = 42), and overall, 37 (88 %) subjects completed the study. The total number of diarrhea days was <1.5 for both treatment sequences, and approximately 60 % of subjects did not experience diarrhea during either treatment period. The mean (SD) number of diarrhea days was lower with miglustat + S. boulardii (0.8 [2.4] days) than with miglustat + placebo (1.3 [2.4] days), but the paired treatment difference was not statistically significant (−0.5 [2.4] days; p = 0.159). However, a significant treatment difference (−0.7 [1.9]; p < 0.05) was identified after post hoc exclusion of a clear outlier who had a very high number of diarrhea days (n = 13) and inconsistent GI tolerability reporting. The incidence of the GI AEs was higher with miglustat + placebo (82 %) than with miglustat + S. boulardii (73 %). There were no between-treatment differences in miglustat pharmacokinetics.ConclusionsAlthough the primary endpoint was not met, the results of the post-hoc analysis suggest that co-administration of miglustat with S. boulardii might improve GI tolerability.

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“…Sucrose is a disaccharide found mainly in sugar cane and beet [ 16 ] and formed by molecules of glucose and fructose, with the elimination of water molecules [ 17 ]. Brazil is the world's largest producer of sucrose, with 420 million tons in 2005.…”

Section: Introductionmentioning

confidence: 99%

Coal Fly Ash Ceramics: Preparation, Characterization, and Use in the Hydrolysis of Sucrose

Santos

Martins

Gadelha

et al. 2014

The Scientific World Journal

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Coal ash is a byproduct of mineral coal combustion in thermal power plants. This residue is responsible for many environmental problems because it pollutes soil, water, and air. Thus, it is important to find ways to reuse it. In this study, coal fly ash, obtained from the Presidente Médici Thermal Power Plant, was utilized in the preparation of ceramic supports for the immobilization of the enzyme invertase and subsequent hydrolysis of sucrose. Coal fly ash supports were prepared at several compaction pressures (63.66–318.30 MPa) and sintered at 1200°C for 4 h. Mineralogical composition (by X-ray diffraction) and surface area were studied. The ceramic prepared with 318.30 MPa presented the highest surface area (35 m2/g) and amount of immobilized enzyme per g of support (76.6 mg/g). In assays involving sucrose inversion, it showed a high degree of hydrolysis (around 81%) even after nine reuses and 30 days' storage. Therefore, coal fly ash ceramics were demonstrated to be a promising biotechnological alternative as an immobilization support for the hydrolysis of sucrose.

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Sugar

Abstract: The article contains sections titled: 1. Terms, Distinguishing Criteria, Uses, Nutritional Physiology 2. History … Show more

Cited by 7 publications

References 38 publications

Trimethylglycine-Betaine-Based-Catalyst-Promoted Novel and Ecocompatible Pseudo-Four-Component Reaction for Regioselective Synthesis of Functionalized 6,8-Dihydro-1′H,5H-spiro[[1,3]dioxolo[4,5-g]quinoline-7,5′-pyrimidine]-2′,4′,6′(3′H)-trione Derivatives

Trimethylglycine-Betaine-Based-Catalyst-Promoted Novel and Ecocompatible Pseudo-Four-Component Reaction for Regioselective Synthesis of Functionalized 6,8-Dihydro-1′H,5H-spiro[[1,3]dioxolo[4,5-g]quinoline-7,5′-pyrimidine]-2′,4′,6′(3′H)-trione Derivatives

A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat

Coal Fly Ash Ceramics: Preparation, Characterization, and Use in the Hydrolysis of Sucrose

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