Sugammadex in Colorectal Surgery: A Systematic Review and Meta-analysis

Chen, Andrew T.; Patel, Ashaka; McKechnie, Tyler; Lee, Yung; Doumouras, Aristithes G.; Hong, Dennis; Eskicioglu, Cagla

doi:10.1016/j.jss.2021.09.026

Cited by 5 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous efforts have investigated the rapid effect of NEO versus SGX during neuromuscular blockade recovery, and failed to demonstrate a significant difference in length of hospital stay in non-heart-transplanted patients undergoing non-thoracic procedures comparing both reversal agents [ 10 , 11 ]. Our study showed a significant difference in hLOS between the two groups, where mean length of stay for the SGX group was 1.53 times that of the NEO.…”

Section: Discussionmentioning

confidence: 99%

An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant

Paredes¹,

Torres²,

Chaves-Cardona³

et al. 2023

ait

View full text Add to dashboard Cite

Based on the United Network for Organ Sharing (UNOS) database, 3 329 patients underwent heart transplantation in the United States in 2021. The development of new surgical techniques and monitoring methods, along with new immunosuppressant drugs, has significantly increased the survival of heart transplant patients [1,2]. Thus, the number of patients who require non-cardiac surgery after heart transplantation is undoubtedly increasing [1,3].Heart transplant recipients present unique perioperative challenges, given their changes in anatomy, physiology, pharmacokinetics, and pharmacodynamics [4]. Specifically, sympathetic and parasympathetic denervation of the heart leads

show abstract

Section: Discussionmentioning

confidence: 99%

An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant

Paredes¹,

Torres²,

Chaves-Cardona³

et al. 2023

ait

View full text Add to dashboard Cite

show abstract

“…In a recently published meta-analysis, Chen et al [41] for the first time compared the postoperative outcomes of sugammadex with a control drug for neuromuscular reversal after colorectal surgery. The authors showed that there was no statistically significant difference between the two groups in total hospital length of stay and rates of adverse respiratory events.…”

Section: Discussionmentioning

confidence: 99%

The Postoperative Effect of Sugammadex versus Acetylcholinesterase Inhibitors in Colorectal Surgery: An Updated Meta-Analysis

Vaghiri

Prassas

Krieg

et al. 2023

JCM

View full text Add to dashboard Cite

Background: the aim of this meta-analysis was to evaluate the postoperative effects of neuromuscular blockade reversal with sugammadex compared with acetylcholinesterase inhibitors in colorectal surgery. Methods: A systematic literature search was performed for studies comparing the postoperative course of patients receiving neuromuscular blockade reversal with either sugammadex or acetylcholinesterase inhibitors (control) after colorectal surgery. Data from eligible studies were extracted, qualitatively assessed, and included in a meta-analysis. Odds ratios and standardized mean differences with 95% confidence intervals (CIs) were calculated. Results: Five studies with a total of 1969 patients were included (sugammadex n = 1137, control n = 832). Sugammadex reversal resulted in a significantly faster return of defecation or flatus after surgery compared to acetylcholinesterase inhibitors (SMD 13.01, 95% CI 6.55–19.46, p = < 0.0001). There were no significant differences between the two groups in other clinical outcomes such as surgical morbidity and length of hospital stay. Conclusion: The present data support the beneficial impact of sugammadex on gastrointestinal motility after colorectal surgery. However, the effect of sugammadex on the prevention of surgical complications and a prolonged hospital stay is diminishing. Larger randomized controlled trials with standardized study protocols are needed to validate the results presented here.

show abstract

“…[ 24 ] In colon surgery, however, no difference in postoperative outcomes with the use of sugammadex was observed. [ 25 ] Based on our extensive literature search, this research is the first meta-analysis to evaluate the effect of sugammadex in lung surgery. In this study, we focused on the population of patients undergoing lung surgery, considered a higher risk of PPCs.…”

Section: Discussionmentioning

confidence: 99%

Sugammadex for reversing neuromuscular blockages after lung surgery: A systematic review and meta-analysis

Yang

Chen

Shen³

et al. 2022

Medicine

View full text Add to dashboard Cite

Background: This study determined whether sugammadex was associated with a lower risk of postoperative pulmonary complications and improved outcomes in lung surgeries. Methods: A systematic literature search was conducted using PubMed, Embase, Web of Science, and the Cochrane Library from January 2000 to March 2022. The characteristics of lung surgeries using sugammadex treatment compared with control drugs and postoperative outcomes were retrieved. The primary outcome was estimated through a pooled odds ratio (OR) and its 95% confidence interval (CI) was identified using a random-effects model. Results: From 465 citations, 7 studies with 453 patients receiving sugammadex and 452 patients receiving a control were included. The risk of postoperative pulmonary complication (PPCs) was lower in the sugammadex group than in the control group. Also, it showed that the effect of sugammadex on PPCs in the subgroup analysis was significantly assessed on the basis of atelectasis or non-atelectasis. Furthermore, subgroup analysis based on the relationship between high body mass index (BMI) and PPCs also showed that sugammadex had less occurrence in both the high BMI (defined as BMI ≥ 25) and low BMI groups. No difference in length of hospital stay (LOS) between the two groups was observed. Conclusion: This study observed that although reversing neuromuscular blockages with sugammadex in patients undergoing thoracic surgery recorded fewer PPCs and shorter extubation periods than conventional reversal agents, no difference in LOS, postanaesthesia care unit (PACU) stay length and chest tube insertion duration in both groups was observed.

show abstract

Sugammadex in Colorectal Surgery: A Systematic Review and Meta-analysis

Cited by 5 publications

References 37 publications

An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant

An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant

The Postoperative Effect of Sugammadex versus Acetylcholinesterase Inhibitors in Colorectal Surgery: An Updated Meta-Analysis

Sugammadex for reversing neuromuscular blockages after lung surgery: A systematic review and meta-analysis

Contact Info

Product

Resources

About