Sufentanil 30 µg Sublingual Tablet: A Review in Acute Pain

Deeks, Emma D.

doi:10.1007/s40261-019-00772-x

Cited by 9 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has high selectivity for opioid receptors, leading to analgesia and sedation. Clinical studies have shown that sufentanil has the highest therapeutic index of all opioids [ 23 ] . As a result, sufentanil can provide stronger analgesic effects over a longer period than the same dose of fentanyl or morphine and can reduce respiratory depression and the incidence of adverse reactions [ 6 , 23 ] .…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies have shown that sufentanil has the highest therapeutic index of all opioids [ 23 ] . As a result, sufentanil can provide stronger analgesic effects over a longer period than the same dose of fentanyl or morphine and can reduce respiratory depression and the incidence of adverse reactions [ 6 , 23 ] . Li and his team reported that administration of sufentanil could reduce emergence agitation in children receiving sevoflurane anesthesia for adenotonsillectomy compared to fentanyl, without delaying the recovery time or causing significant hypotension [ 24 ] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sufentanil Reduces Emergence Delirium in Children Undergoing Transthoracic Device Closure of VSD After Sevoflurane-Based Cardiac Anesthesia

Xu¹,

Chen²,

Huang³

et al. 2020

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Objective The aim of this study was to evaluate whether sufentanil can reduce emergence delirium in children undergoing transthoracic device closure of ventricular septal defect (VSD) after sevoflurane-based cardiac anesthesia. Methods From February 2019 to May 2019, 68 children who underwent transthoracic device closure of VSD at our center were retrospectively analyzed. All patients were divided into two groups: 36 patients in group S, who were given sufentanil and sevoflurane-based cardiac anesthesia, and 32 patients in group F, who were given fentanyl and sevoflurane-based cardiac anesthesia. The following clinical data were recorded: age, sex, body weight, operation time, and bispectral index (BIS). After the children were sent to the intensive care unit (ICU), pediatric anesthesia emergence delirium (PAED) and face, legs, activity, cry, consolability (FLACC) scale scores were also assessed. The incidence of adverse reactions, such as nausea, vomiting, drowsiness and dizziness, was recorded. Results There was no significant difference in age, sex, body weight, operation time or BIS value between the two groups. Extubation time (min), PEAD score and FLACC scale score in group S were significantly better than those in group F ( P <0.05). No serious anesthesia or drug-related side effects occurred. Conclusions Sufentanil can be safely used in sevoflurane-based fast-track cardiac anesthesia for transthoracic device closure of VSD in children. Compared to fentanyl, sufentanil is more effective in reducing postoperative emergence delirium, with lower analgesia scores and greater comfort.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sufentanil Reduces Emergence Delirium in Children Undergoing Transthoracic Device Closure of VSD After Sevoflurane-Based Cardiac Anesthesia

Xu¹,

Chen²,

Huang³

et al. 2020

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

show abstract

“…Therapeutic index is calculated as half-maximal lethal dose divided by half-maximal effective dose. 11 In comparison, the therapeutic indices of fentanyl and morphine are 277 and 71, respectively. 12 This may result in a lower incidence of adverse drug reactions such as respiratory depression with sufentanil when compared with morphine and fentanyl at equivalent doses.…”

Section: Pharmacologymentioning

confidence: 99%

“…Hepatic and renal function do not affect the clearance of SST. 11,15 The half-time of SST is not context sensitive because it does not increase with prolonged administration. SST displays high plasma protein binding, estimated to be approximately 93% in healthy males.…”

Section: Pharmacokineticsmentioning

confidence: 99%

See 1 more Smart Citation

Sufentanil Sublingual Tablet: A New Option for Acute Pain Management

et al. 2019

View full text Add to dashboard Cite

Objective: The purpose of this article is to review the safety and efficacy of sufentanil sublingual tablet (SST) and suggest its place in therapy for managing acute pain in patients requiring intravenous (IV) opioids. Data Sources: A MEDLINE/PubMed search was performed (2010 to April 2019) using the following keywords: sufentanil sublingual tablet, sufentanil, opioid, moderate to severe acute pain. Study Selection and Data Extraction Quantification: We included English language articles evaluating SST pharmacology, pharmacokinetics, efficacy, and safety in humans for the treatment of acute pain. Data Synthesis: SST is Food and Drug Administration approved and considered safe and effective for the treatment of acute pain in Risk Evaluation and Mitigation Strategy–certified and medically supervised health care settings. Phase III clinical trials showed a statistically significant decrease in summed pain intensity score when SST was compared with placebo. Relevance to Patient Care and Clinical Practice: SST can be a useful option in patients requiring a parenteral opioid who do not have IV access, or it may be unnecessary or difficult to obtain. Because of its quick onset and sustained analgesia, SST may also be useful for procedural pain in the critically ill, to expedite discharges for outpatient procedures, in emergency departments (EDs), and in the battlefield. Conclusions: SST can satisfy an unmet need in patients with acute pain, who require parenteral opioids, and either have no IV access or require prolonged time to achieve IV access such as patients in outpatient surgical centers, EDs, and the battlefield. During periods of parenteral opioid shortage, SST may provide another option for adequate analgesia.

show abstract