Sudomotor dysfunction in diabetic peripheral neuropathy (DPN) and its testing modalities: A literature review

Akbar, Muhammad; Wandy, Alvian; Soraya, Gita Vita; Goysal, Yudy; Lotisna, Mimi; Basri, Muhammad Iqbal

doi:10.1016/j.heliyon.2023.e18184

Cited by 3 publications

(2 citation statements)

References 149 publications

(193 reference statements)

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“…Diabetic peripheral neuropathy (DPN) is the main form of neuropathy and a leading cause of disability. Small fiber neuropathy (SFN) can develop in older people with pre-diabetes, prior to large fiber damage ( Akbar et al, 2023 ). The symptoms of DPN consist primarily of spontaneous, intractable pain that is diffuse and persistent and can last for weeks to months.…”

Section: Treatment Principles Of Elderly Diabetesmentioning

confidence: 99%

Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine

Yang,

Xue,

Chen

et al. 2024

Front. Pharmacol.

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Diabetes mellitus has become a major public health issue globally, putting an enormous burden on global health systems and people. Among all diseased groups, a considerable part of patients are elderly, while their clinical features, pathogenic processes, and medication regimens are different from patients of other ages. Despite the availability of multiple therapies and techniques, there are still numerous elderly diabetes patients suffering from poor blood glucose control, severe complications, and drug adverse effects, which negatively affect the quality of life in their golden years. Traditional Chinese Medicine (TCM) has been widely used in the treatment of diabetes for several decades, and its relevant clinical practice has confirmed that it has a satisfactory effect on alleviating clinical symptoms and mitigating the progression of complications. Chinese herbal medicine and its active components were used widely with obvious clinical advantages by multiple targets and signaling pathways. However, due to the particular features of elderly diabetes, few studies were conducted to explore Traditional Chinese Medicine intervention on elderly diabetic patients. This study reviews the research on clinical features, pathogenic processes, treatment principles, and TCM treatments, hoping to provide fresh perspectives on the prevention and management strategies for elderly diabetes.

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Section: Treatment Principles Of Elderly Diabetesmentioning

confidence: 99%

Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine

Yang,

Xue,

Chen

et al. 2024

Front. Pharmacol.

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“…Untreated DPN has substantial effects on patient morbidity and quality of life (i.e., loss of limb sensation, falls, and increased risk of foot ulcers and lower limb amputations), while diabetic patients with DPN are also at higher risk of all-cause and cardiovascular mortality than those without DPN ( 3 , 5 , 7 , 15 – 17 ).…”

Section: Introductionmentioning

confidence: 99%

Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach

Atmaca,

Ketenci,

Sahin

et al. 2024

Front. Endocrinol.

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The proposed expert opinion aimed to address the current knowledge on conceptual, clinical, and therapeutic aspects of diabetic peripheral neuropathy (DPN) and to provide a guidance document to assist clinicians for the best practice in DPN care. The participating experts consider the suspicion of the disease by clinicians as a key factor in early recognition and diagnosis, emphasizing an improved awareness of the disease by the first-admission or referring physicians. The proposed “screening and diagnostic” algorithm involves the consideration of DPN in a patient with prediabetes or diabetes who presents with neuropathic symptoms and/or signs of neuropathy in the presence of DPN risk factors, with careful consideration of laboratory testing to rule out other causes of distal symmetric peripheral neuropathy and referral for a detailed neurological work-up for a confirmative test of either small or large nerve fiber dysfunction in atypical cases. Although, the first-line interventions for DPN are currently represented by optimized glycemic control (mainly for type 1 diabetes) and multifactorial intervention (mainly for type 2 diabetes), there is a need for individualized pathogenesis-directed treatment approaches for DPN. Alpha-lipoic acid (ALA) seems to be an important first-line pathogenesis-directed agent, given that it is a direct and indirect antioxidant that works with a strategy targeted directly against reactive oxygen species and indirectly in favor of endogenous antioxidant capacity for improving DPN conditions. There is still a gap in existing research in the field, necessitating well-designed, robust, multicenter clinical trials with sensitive endpoints and standardized protocols to facilitate the diagnosis of DPN via a simple and effective algorithm and to track progression of disease and treatment response. Identification of biomarkers/predictors that would allow an individualized approach from a potentially disease-modifying perspective may provide opportunities for novel treatments that would be efficacious in early stages of DPN, and may modify the natural course of the disease. This expert opinion document is expected to increase awareness among physicians about conceptual, clinical, and therapeutic aspects of DPN and to assist them in timely recognition of DPN and translating this information into their clinical practice for best practice in the management of patients with DPN.

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Electrodermal activity and its molecular mechanisms: Unraveling insights into skin diseases

Zhu,

Song,

Liu

et al. 2024

TIL

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<p>Electrodermal activity (EDA) refers to the changes in electrical potential recorded on the skin surface, which mainly reflect the electrical properties of the skin and sympathetic nerve activity reflected by sweat secretion. Various dermatoses impair the skin barrier and alter the function of innervated nerves, resulting in significant fluctuations in EDA. This manuscript aims to provide a comprehensive overview of the molecular mechanisms underlying representative skin symptoms related to inflammation, fibrosis, and sweat gland disorders, and to explore the correlation of these mechanisms with EDA components. The physiological significance of EDA is discussed to provide a new perspective for the clinical application of EDA.</p>

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Sudomotor dysfunction in diabetic peripheral neuropathy (DPN) and its testing modalities: A literature review

Cited by 3 publications

References 149 publications

Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine

Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine

Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach

Electrodermal activity and its molecular mechanisms: Unraveling insights into skin diseases

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