Sudden unexpected death in Parkinson's disease: Insights from clinical practice

Scorza, Fúlvio A.; Guimarães‐Marques, Marcia; Nejm, Mariana Bocca; Almeida, Antônio-Carlos G. de; Scorza, Carla A.; Fiorini, Ana Cláudia; Finsterer, Josef

doi:10.1016/j.clinsp.2021.100001

Cited by 6 publications

(2 citation statements)

References 85 publications

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“…The global burden of PD has more than doubled due to the increased age of the population. 8 PD patients have a 3.8-fold increased risk of death. 9 Presently, there is only symptomatic treatment for PD, although it cannot delay the onset and early progress of the disease.…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

et al. 2023

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“…There is no appropriate vaccination for E. xiangfangensis , which exacerbates the global issue [ 7 ]. Recommendations, such as adapting antibiotic management programs and improving diagnostic decision-making processes, and follow-up can increase the efficacy of infectious disease therapy and slow the emergence of bacterial resistance [ 8 ]. Hence, the development of an effective treatment strategy for E. xiangfangensis , as well as potent drugs and novel therapeutic targets, is critical.…”

Section: Introductionmentioning

confidence: 99%

Integrated Pangenome Analysis and Pharmacophore Modeling Revealed Potential Novel Inhibitors against Enterobacter xiangfangensis

Almuhayawi

Jaouni

Selim

et al. 2022

IJERPH

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Enterobacter xiangfangensis is a novel, multidrug-resistant pathogen belonging to the Enterobacter genus and has the ability to acquire resistance to multiple antibiotic classes. However, there is currently no registered E. xiangfangensis drug on the market that has been shown to be effective. Hence, there is an urgent need to identify novel therapeutic targets and effective treatments for E. xiangfangensis. In the current study, a bacterial pan genome analysis and subtractive proteomics approach was employed to the core proteomes of six strains of E. xiangfangensis using several bioinformatic tools, software, and servers. However, 2611 nonredundant proteins were predicted from the 21,720 core proteins of core proteome. Out of 2611 nonredundant proteins, 372 were obtained from Geptop2.0 as essential proteins. After the subtractive proteomics and subcellular localization analysis, only 133 proteins were found in cytoplasm. All cytoplasmic proteins were examined using BLASTp against the virulence factor database, which classifies 20 therapeutic targets as virulent. Out of these 20, 3 cytoplasmic proteins: ferric iron uptake transcriptional regulator (FUR), UDP-2,3diacylglucosamine diphosphatase (UDP), and lipid-A-disaccharide synthase (lpxB) were chosen as potential drug targets. These drug targets are important for bacterial survival, virulence, and growth and could be used as therapeutic targets. More than 2500 plant chemicals were used to molecularly dock these proteins. Furthermore, the lowest-binding energetic docked compounds were found. The top five hit compounds, Adenine, Mollugin, Xanthohumol C, Sakuranetin, and Toosendanin demonstrated optimum binding against all three target proteins. Furthermore, molecular dynamics simulations and MM/GBSA analyses validated the stability of ligand–protein complexes and revealed that these compounds could serve as potential E. xiangfangensis replication inhibitors. Consequently, this study marks a significant step forward in the creation of new and powerful drugs against E. xiangfangensis. Future studies should validate these targets experimentally to prove their function in E. xiangfangensis survival and virulence.

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Parkinson's disease inpatient mortality: Attention to sudden death

de la Rosa,

Scorza

2024

Clinics

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Sudden unexpected death in Parkinson's disease: Insights from clinical practice

Cited by 6 publications

References 85 publications

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

Integrated Pangenome Analysis and Pharmacophore Modeling Revealed Potential Novel Inhibitors against Enterobacter xiangfangensis

Parkinson's disease inpatient mortality: Attention to sudden death

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