Sudden sensory neural hearing loss is not predictive of myocardial infarction: A longitudinal follow-up study using a national sample cohort

Abstract

The aim of this study was to evaluate the risk of myocardial infarction (MI) in SSNHL subjects with differently matched control groups. The Korean Health Insurance Review and Assessment Service - National Sample Cohort recruited subjects from 2002 to 2013. We used two study designs. In study I, we matched 4,467 SSNHL participants with a control group (17,868 subjects with no history of SSNHL) based on demographic factors (age, sex, income, and region of residence) and medical history (diabetes, dyslipidemia, and hypertension). In study II, we matched 4,467 SSNHL participants with a control group based on only demographic factors. The crude (simple) and adjusted hazard ratios (HRs) of SSNHL with MI were analyzed using the Cox-proportional hazard model. In study I, SSNHL was not associated with increased risk of MI. However, in study II, SSNHL was associated with increased risk of MI (adjusted HR = 1.39 95% CI = 1.00–1.93, P = 0.048). The SSNHL group did not exhibit increased risk of MI when compared to the control group matched by both demographic factors and medical history. However, compared to the control group not matched by medical history, the relative risk of MI was increased in the SSNHL group.

Pregnancy Does Not Increase the Risk of Sudden Sensorineural Hearing Loss: A National Cohort Study

“…Given that the cochlea are primarily affected by the end‐arterial supply from the anterior inferior cerebellar artery, whether the pregnancy‐associated hypercoagulable state influences thrombotic arterial occlusion in the cochlea remains unknown. Using a large population‐based study, we recently reported no association between SSNHL and myocardial ischemia, even after excluding confounding factors, including systemic inflammatory mediators . Considering that specific etiologies of SSNHL, such as viral infection, ischemic insult, and autoimmunity, have been identified in only approximately 10% of patients, the risk of the ischemic insult that may precipitate SSNHL remains enigmatic.…”

“…The reported global incidence of SSNHL varied from 5 to 20 per 100,000 individuals . In Korea, the annual incidence is approximately 10 per 100,000 individuals . The exact pathophysiology of SSNHL has not yet been clearly elucidated in most cases .…”

“…1 In Korea, the annual incidence is approximately 10 per 100,000 individuals. 2 The exact pathophysiology of SSNHL has not yet been clearly elucidated in most cases. [1][2][3] Nonetheless, SSNHL can manifest as a consequence of systemic physiological changes that deteriorate the inner-ear environment.…”

“…2 The exact pathophysiology of SSNHL has not yet been clearly elucidated in most cases. [1][2][3] Nonetheless, SSNHL can manifest as a consequence of systemic physiological changes that deteriorate the inner-ear environment. In particular, the cochlea are very susceptible to compromised vascular microcirculation due to their endarterial blood supply and higher metabolic demands.…”

“…In particular, the cochlea are very susceptible to compromised vascular microcirculation due to their endarterial blood supply and higher metabolic demands. 2 Pregnancy is a unique condition for women and is characterized by a series of physiological changes in all body systems, including the auditory system. 4 For example, delayed latency and increased thresholds of auditory brainstem response wave V have been reported in pregnant women.…”