Sudden Sensorineural Hearing Loss in patient with Chronic Myelogenous Leukemia – A case study

Kayode, Aremu Shuaib; Adeleke, Ibijola Ajayi; Oluwatona, Dosunmu Adepeju

doi:10.17352/2455-1759.000082

Cited by 2 publications

(9 citation statements)

References 9 publications

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“…17–19 In our case, the patient had an extremely high WBC count of 780.72 × 10 9 /L and splenomegaly Schuffner 5. These data suggest that, among the multifactorial pathogenesis of CML, 5 , 6 , 8 , 10 , 17 , 22 the most notable in our case was hyperleukocytosis.…”

Section: Discussionsupporting

confidence: 54%

“…Hearing loss as a primary symptom of CML is uncommon. 3 , 5 , 6 , 17 , 18 , 20 Hearing loss in CML could be unilateral or bilateral SNHL, or it may begin as unilateral then progress to bilateral. 18 There have been only a few cases of juvenile CML in which SNHL was reported in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“… 5 , 6 , 8 , 10 , 17 , 22 According to Kayode et al, hyperleukocytosis with leukostasis in the labyrinthine artery and other minor arteries of the vertebrobasilar area causes bilateral deafness in CML patients. 5 …”

Section: Discussionmentioning

confidence: 99%

“…Leukemia patients with otologics manifestations are seen in 15–40% of cases. 3 , 5 , 8 Unilateral or bilateral sensorineural hearing loss (SNHL), tinnitus, dizziness, and facial nerve paresis are among the symptoms. 3 , 18 Hearing loss has been linked to acute leukemias; however, it is uncommon in patients with CML, 3 , 5 , 6 , 17 , 18 , 20 especially in childhood; 15 it may develop later in the disease course than in acute leukemia.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 5 , 8 Unilateral or bilateral sensorineural hearing loss (SNHL), tinnitus, dizziness, and facial nerve paresis are among the symptoms. 3 , 18 Hearing loss has been linked to acute leukemias; however, it is uncommon in patients with CML, 3 , 5 , 6 , 17 , 18 , 20 especially in childhood; 15 it may develop later in the disease course than in acute leukemia. 5 This rarity is supported by a study that reported ocular symptoms and priapism as the most common leukostasis symptoms in juvenile CML.…”

Section: Introductionmentioning

confidence: 99%

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Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2–3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

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