Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck

Abstract

Hyperhomocysteinemia proved to be a risk factor for sudden sensorineural hearing loss. Based on these results, we propose to analyse homocysteine in sudden sensorineural hearing loss patients and, if its values are high, to evaluate the presence of MTHFR C677T mutation.

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

“…Although Hcy concentrations reflect alterations in its metabolism (Figure 1), which include the methionine and folate cycles, as well as the transsulfuration pathway, no consistent association between mutations in genes of these pathways and SNHL has been reported (Durga et al, 2006; Uchida et al, 2011). Analysis of the putative relationship between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and ARHL rendered contradictory results (Durga et al, 2006), since this allele has been correlated with hearing impairment and HHcy, and also with a reduced risk of ARHL independent from folate and Hcy levels (Uchida et al, 2011; Fusconi et al, 2012). …”

Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice

“…This fact, led several authors to the evaluation of the putative contribution of human mutations to these disparities and, among them, the analysis of modifications in key genes of the one-carbon metabolism. Evaluation of the relationship between the polymorphism C677T in the methylenetetrahydrofolate reductase gene, a key player in folate metabolism, and hearing loss rendered contradictory results (Durga et al, 2006; Uchida et al, 2011; Fusconi et al, 2012). In contrast, animal studies have provided clues to the interplay between folate, Hcy and hearing loss, showing alterations in Hcy metabolism correlating with the onset of this impairment (Cohen-Salmon et al, 2007; Kundu et al, 2012; Martinez-Vega et al, 2015a).…”

Role of factor V Leiden polymorphism or G20210A prothrombin variant in patients with sudden sensorineural hearing loss: A meta-analysis of the literature

“…The median Newcastle-Ottawa quality score for the included studies was seven (range, [6][7][8][9]. Most of the studies analyzed both thrombophilic conditions concomitantly (Fig.…”

“…Literature search results consisted of 14 articles [2,[4][5][6][7][8][9][10][11][12][13][14][15][16] which analyzed SSHL in relation to "FVL" and 20 articles [2][3][4][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] in relation to "PT" variant. The median Newcastle-Ottawa quality score for the included studies was seven (range, [6][7][8][9].…”