Sudden sensori-neural hearing loss treated by carbon dioxide and oxygen inhalation

Bahgat, Mohammed; Shenoi, P. M.

doi:10.1017/s0022215100092240

Cited by 9 publications

(4 citation statements)

References 13 publications

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“…Previous reports have described treatment of sudden hearing loss with: stellate ganglion blockage, vasodilators (oral papaverine, histamine infusion, oral nicotinic acid and inhaled carbogen therapy), anticoagulant drugs, low molecular weight dextran, corticosteroids, diuretics and sedative drugs. Hyperbaric oxygen therapy has been recommended as definitive treatment 7 – 10 …”

Section: Discussionmentioning

confidence: 99%

Effectiveness of hyperbaric oxygen therapy in management of sudden hearing loss

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Effectiveness of hyperbaric oxygen therapy in management of sudden hearing loss

et al. 2009

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“…Steroids, heparin and papaverine have been recommended to improve oxygenation to the injured area. Inhalation of five per cent CO, with 95 per cent O : has also been employed for the same purpose (Bahgat and Shenoi, 1982) and in more desperate cases stellate blocks and hyperbaric oxygen have been tried (Goto et al, 1979). In our patient we instituted the conventional methods for intensive management of acute deafness to no avail.…”

Section: Discussionmentioning

confidence: 99%

Acute bilateral total deafness complicating mumps

1986

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While it is well known that mumps is a potential cause of deafness, it is not generally appreciated that it can produce total deafness. The damage is usually unilateral but bilateral disease has been recorded. A case is presented of severe bilateral hearing loss during a mumps epidemic in which, in spite of intensive conventional as well as lesser known therapy, no improvement occurred. In the absence of a successful therapeutic regime it is clearly advisable to intensify immunization in non-developed countries.

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“…Some of the earliest histological studies lending support for a vascular injury model were described in the 1950s (16)(17)(18)(19)(20). Perlman et al (21)(22)(23)(24)(25) systematically demonstrated through animal studies that disruption of the vascular supply to the inner ear produced devastating histopathologic changes to the cochlea and profound hearing loss. They established the foundation for other laboratory and clinical studies that supported the theory of microcirculatory compromise to the inner ear as the etiology of ISSNHL.…”

Section: Historical Circumstance 1: Attempts To Identify the Etiology...mentioning

confidence: 99%

“…They established the foundation for other laboratory and clinical studies that supported the theory of microcirculatory compromise to the inner ear as the etiology of ISSNHL. With evidence supporting this theory, various therapies for ISSNHL aimed at improving blood flow to the inner ear were proposed such as calcium channel blockers (26); dextran (an anti-thrombotic agent) (27); vasodilator agents such as histamine, procaine, and nicotinic acid (28); and carbogen gas (95% O 2 /5% CO 2 ), which could be inhaled by a patient (23,25).…”

Section: Historical Circumstance 1: Attempts To Identify the Etiology...mentioning

confidence: 99%

Roid Rage: Historical Perspective on the Emergence of Oral Steroids as a Treatment of Idiopathic Sudden Sensorineural Hearing Loss

et al. 2023

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ObjectivesTo review the historical circumstances that led to the emergence of corticosteroid therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) and to discuss how this history has influenced current perspectives on the condition.MethodsPubMed and Google scholar were used to identify articles of ISSNHL and oral corticoid steroid use. Historical articles accessed through our institutional medical library were also reviewed.ResultsThe use oral corticosteroids as a treatment for ISSNHL was seemingly influenced by three key historical circumstances that, together, provided the substrate for the treatment’s use in ISSNHL. First, ISSNHL was a frustrating condition with uncertainty regarding its etiology and few reliable treatment options. Second, the discovery of corticosteroids was awarded the Nobel Prize in 1950, which led to widespread application of this therapy. Third historical circumstance was the evolution and emergence of more rigorous methodological study designs in clinical research. In 1980, these events culminated in a double-blind study evaluating the effectiveness of oral steroids for treatment of ISSNHL. Interestingly, this study is often misrepresented as a randomized controlled trial, which ultimately contributed to adoption of a new standard for treatment in ISSNHL. Research subsequent to these historical events has challenged the notion of corticosteroids as a gold standard but has not altered the historically established paradigm of corticosteroid treatment.ConclusionsThe use of steroids as a treatment for ISSNHL evolved from our specialty’s need to address a complex condition, a novel therapeutic discovery, and a landmark study that met emerging methodological standards. Despite these strong historical foundations, ISSNHL remains a condition with an unknown etiology and the therapeutic value of corticosteroids remains unpredictable despite their gold standard label.

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Sudden sensori-neural hearing loss treated by carbon dioxide and oxygen inhalation

Cited by 9 publications

References 13 publications

Effectiveness of hyperbaric oxygen therapy in management of sudden hearing loss

Effectiveness of hyperbaric oxygen therapy in management of sudden hearing loss

Acute bilateral total deafness complicating mumps

Roid Rage: Historical Perspective on the Emergence of Oral Steroids as a Treatment of Idiopathic Sudden Sensorineural Hearing Loss

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