Sudden Retinal Manifestations of Intranasal Cocaine and Methamphetamine Abuse

Wallace, R. Trent; Brown, Gary C.; Benson, William E.; Sivalingham, Arunan

doi:10.1016/s0002-9394(14)73979-0

Cited by 49 publications

(36 citation statements)

References 5 publications

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“…The intranasal route of drug administration has equally injurious effects on the eyes intrinsic vascular structures (Wallace et al 1992). In fact, intranasal ingestion of METH can place an individual at increased risk of central retinal artery occlusion with resultant vision defects (Wallace et al 1992).…”

Section: Effects On Adultsmentioning

confidence: 99%

“…In fact, intranasal ingestion of METH can place an individual at increased risk of central retinal artery occlusion with resultant vision defects (Wallace et al 1992). Furthermore, a patient using intranasal METH may develop intraretinal hemorrhages as well as other retinal vascular manifestations (Wallace et al 1992). The drug's ability to inflict ruinous vascular damage is not confined to the vascular structures of the eye but can also affect vital neurovascular structures throughout the central nervous system (CNS).…”

Section: Effects On Adultsmentioning

confidence: 99%

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Ocular Manifestations of Crystal Methamphetamine Use

Hazin

Cadet²,

Kahook

et al. 2009

Neurotox Res

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Numerous medical sequelae associated with illicit drug use have been reported. Nevertheless, there has been scarce documentation of the effects of these drugs on the eyes. Drug-induced ocular symptoms include decreased visual acuity, disturbances in perception, and even flashbacks. Methamphetamine (METH) is a highly addictive drug whose abuse has spread worldwide during the past two decades. METH abuse is associated with many adverse psychiatric and medical consequences including strokes and psychosis. METH-induced ophthalmic complications are rarely discussed but include retinal vasculitis, episcleritis, panophthalmitis, endophthalmitis, scleritis, retinopathy, corneal ulceration, and transient visual losses. Because the drug has shown a marked increase in the prevalence of its use amongst pregnant women, there has also been an increase of drug-induced complications in fetuses and newborn babies. These complications need to be further detailed and studied. Herein, the authors report on the ocular complications associated with METH abuse. They also discuss some potential mechanisms for the toxic effects of the drug on that system.

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Section: Effects On Adultsmentioning

confidence: 99%

Section: Effects On Adultsmentioning

confidence: 99%

Ocular Manifestations of Crystal Methamphetamine Use

Hazin

Cadet²,

Kahook

et al. 2009

Neurotox Res

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“…Ophthalmic complications described in literature include, bilateral internuclear ophthalmoplegia, 2 and central retinal artery occlusion, 3 there has been no report in the literature about hyphaema. There have been several case reports indicating onset of subarachnoid haemorrhage, 4,5 stroke, and other neurological disorders following cocaine use.…”

Section: Commentmentioning

confidence: 99%

Spontaneous hyphaema: blunt trauma and cocaine abuse

Kumar

Dhir

Prasad

2006

Eye

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“…Even though we could not see a transient artery occlusion, we may speculate that a decreased ocular perfusion at the level of the DCP following use of cocaine might play a key role in the pathogenesis of AMN. Adrenomimetic response associated with the intranasal use of cocaine (Wallace et al 1992) may have also contributed to the pathogenesis of AMN, as intranasal injection of epinephrine during rhinosurgery has been reported to be associated in a case of AMN (Wessel et al 2013).…”

mentioning

confidence: 99%