Sudden onset of paraplegia caused by subarachnoid hemorrhage associated with meningeal melanocytoma of the conus medullaris: a case report of intraoperative identification of these two pathological conditions

Hioki, Atsushi; Miyamoto, Kei; Kato, Hiroki; Hatano, Yuichiro; Asano, Nami; Hirose, Yoshinobu; Fushimi, Kazunari; Shimizu, Katsuji

doi:10.1007/s00590-011-0799-5

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Twenty-three patients were identified, who were predominantly males ( n = 17). The mean age at which patients first presented was 40.6 years (5–72) [ 9 , 10 ]. Common presentations include leg weakness ( n = 8) [ 6 , 7 , 9 , 11–15 ], neck pain ( n = 5) [ 16–20 ] and back pain ( n = 4) [ 10 , 11 , 14 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mean age at which patients first presented was 40.6 years (5–72) [ 9 , 10 ]. Common presentations include leg weakness ( n = 8) [ 6 , 7 , 9 , 11–15 ], neck pain ( n = 5) [ 16–20 ] and back pain ( n = 4) [ 10 , 11 , 14 , 21 ]. The average duration of symptoms prior to initial presentation was 8.7 months (0.07–36); 43% ( n = 10) cases were in the cervical region, 43% ( n = 10) were in the thoracic region, 9% ( n = 2) were in the sacral region and 4% ( n = 1) were in the lumbar region of the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

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Intradural extramedullary meningeal melanocytoma: a case report and literature review

Parwez

Ahmed

Baig

et al. 2023

Journal of Surgical Case Reports

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Primary meningeal melanocytomas are extremely rare, benign tumours arising from the leptomeninges. While they are considered to be benign lesions, there is potential for their growth and transformation into malignant melanomas. They are commonly found in the cervical spine, with a decreased incidence in the thoracic and lumbar regions. We present a case report of a 56-year-old man who presented to our unit with a 4-month history of lower limb weakness and a sensory level at T6. Magnetic resonance imaging shows an intradural extramedullary tumour. The patient underwent a thoracic debulking of the lesion with neurophysiological monitoring. Histopathology confirmed the diagnosis of melanocytoma of meningeal origin, with a low mitotic count. Our patient recovered well post-operatively with no complications. Surgical resection is an effective method to manage this tumour; however, adjuvant radiotherapy is advised due to the risk of recurrence and malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intradural extramedullary meningeal melanocytoma: a case report and literature review

Parwez

Ahmed

Baig

et al. 2023

Journal of Surgical Case Reports

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How Should We Treat Meningeal Melanocytoma? A Retrospective Analysis of Potential Treatment Strategies

Ricchizzi

Gallus

Stummer

et al. 2022

Cancers

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Background: Meningeal melanocytomas (MM) are rare primary melanocytic tumors of the leptomeninges with an incidence of 1:10,000,000. Until now, there has been only sparse information about this tumor entity. Here, we provide a meta-analysis of all cases published in the English language since 1972. Methods: A literature review was performed using PubMed and Web of Science. All published cases were evaluated for location, sex, age, therapeutic approach, and outcome. In total, we included 201 patient cases in our meta–analysis. Results: The majority of MM was diagnosed more frequently in men between the third and fifth decade of life. Surgery is the preferred therapeutic approach, and total resection is associated with the best outcome. Patients with partial resection or tumor recurrence benefit from adjuvant radiotherapy, whereas chemo- or immunotherapies do not improve the disease course. Malignant transformation was described in 18 patients. Of these, 11 patients developed metastasis. Conclusions: We present the first retrospective meta-analysis of all MM cases published in the English language, including an evaluation of different treatment strategies allowing us to suggest a novel treatment guideline highlighting the importance of total resection for recurrence–free survival and characterizing those cases which benefit from adjuvant radiotherapy.

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Sudden onset of paraplegia caused by subarachnoid hemorrhage associated with meningeal melanocytoma of the conus medullaris: a case report of intraoperative identification of these two pathological conditions

Cited by 2 publications

References 9 publications

Intradural extramedullary meningeal melanocytoma: a case report and literature review

Intradural extramedullary meningeal melanocytoma: a case report and literature review

How Should We Treat Meningeal Melanocytoma? A Retrospective Analysis of Potential Treatment Strategies

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