Sudden infant death due to disseminated pneumococcal infection

Thayyil, Sudhin; Murthy, Vadivelampalayam N.; Thompson, Fiona

doi:10.1136/adc.88.2.157

Cited by 1 publication

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References 4 publications

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“…In studies in the 1990s, Streptococcus pneumoniae was isolated from a significantly higher proportion of SIDS infants (11%) compared to healthy infants matched for age, sex, and locality ( 10 ). While rare, pneumococcal infections have been implicated in sudden infant deaths ( 11 ). It was noted in our data that there was a sharp decline in SIDS following introduction of the pneumococcal vaccine in 2008 (Figure 3 ) and it has remained below the numbers prior to 2008.…”

Section: Discussionmentioning

confidence: 99%

Evidence for Infection and Inflammation in Infant Deaths in a Country with Historically Low Incidences of Sudden Infant Death Syndrome

et al. 2015

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Total infant mortality in Hungary has been higher than other European countries; however, the reported incidence of sudden infant death syndrome (SIDS) has been lower. The low incidence of SIDS in Hungary has been supported by evidence obtained from the high rate of scene of death investigation and medico-legal autopsy mandatory since the 1950s. In this study, we compared the incidence of explained and unexplained infant deaths in Hungary for three periods: 1979–1989 when the incidence of SIDS was high in western Europe; 1990–1999 when the incidence of infant deaths was falling following introduction of the public health campaigns to reduce the risk factors associated with SIDS; and 2000–2012 to determine if introduction of Haemophilus influenzae type b or pneumococcal vaccines or introduction of an earlier immunization schedule during this period had an effect on SIDS. Explained infant deaths fell consistently during this period; however, SIDS rose during the second period when the incidence of SIDS was falling in other European countries. Evidence for infection and/or inflammation was observed for the majority of SIDS during each period. The results are discussed in relation to campaigns to reduce infant mortality in Hungary and the introduction of new vaccines and an earlier immunization schedule in 2006.

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Section: Discussionmentioning

confidence: 99%