Sudden increase of vancomycin-resistant enterococcal infections in a Korean tertiary care hospital: possible consequences of increased use of oral vancomycin

Shin, Jeong Won; Yong, Dongeun; Kim, Myung Sook; Chang, Kyung Hee; Lee, Kyungwon; Kim, June Myung; Chong, Yunsop

doi:10.1007/s10156-002-0215-5

Cited by 39 publications

(31 citation statements)

References 26 publications

(17 reference statements)

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“…Nosocomial VRE, which rapidly emerged in the United States in the 1990s after their initial discovery in Europe, are found in increasing rates in hospitals in Europe, Asia, and South America (5)(6)(7)9,23,29,30). The data presented in this study show that most of these hospital-derived VRE are part of a single clonal lineage.…”

Section: Discussionmentioning

confidence: 99%

Global Spread of Vancomycin-resistantEnterococcus faeciumfrom Distinct Nosocomial Genetic Complex

Willems

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Santen

et al. 2005

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

Global Spread of Vancomycin-resistantEnterococcus faeciumfrom Distinct Nosocomial Genetic Complex

Willems

Top

Santen

et al. 2005

Emerg. Infect. Dis.

483

400

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“…on April 7, 2019 by guest http://jcm.asm.org/ mechanism in the dissemination of the van gene (11,15). VanB VRE were predominantly isolated in Korean hospitals in the initial years, whereas recent isolates (those recovered from 1998 to 2000) were mostly of the VanA type (11,15).…”

Section: Vol 42 2004mentioning

confidence: 99%

“…VanB VRE were predominantly isolated in Korean hospitals in the initial years, whereas recent isolates (those recovered from 1998 to 2000) were mostly of the VanA type (11,15). Therefore, structural analysis of the vanA gene cluster is critical to investigations of the epidemiology of vanA-containing enterococci from Korean hospitals.…”

Section: Vol 42 2004mentioning

confidence: 99%

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Distribution of Insertion Sequences Associated with Tn 1546 -Like Elements among Enterococcus faecium Isolates from Patients in Korea

Huh

Lee

et al. 2004

J Clin Microbiol

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The vanA gene cluster is carried as a part of Tn1546-like elements. The genetic diversity in Tn1546-like elements has been documented previously. The differences described thus far have included the integration of insertion sequence (IS) elements IS1216V, IS1251, IS1476, and IS1542. Among these, IS1216V has been reported to be widespread in VanA enterococci of diverse geographic areas, whereas IS1542 and IS1476 have been reported only in the United Kingdom and Canada, respectively. We investigated the distribution of ISs among 20 vanA-containing Enterococcus faecium isolates from human patients in nine different university hospitals in Korea. Pulsed-field gel electrophoresis (PFGE) was performed to identify the clonality of the isolates. Moreover, PCR amplification of the internal regions of Tn1546 was performed for structural analysis of the van gene, and both DNA strands of the PCR amplicons were directly sequenced by the dideoxy termination method. The PFGE patterns revealed a high degree of clonal diversity. Structural analyses of the van gene detected IS1542 and IS1216V in the genomes of all 20 isolates, whereas it did not detect IS1476 or IS1251 in the genomes of any of the isolates. In addition, IS19 was detected in the vanS-vanH intergenic region of one isolate. These data indicate that identification of the IS within a vanA gene cluster could be a useful tool in epidemiological investigations. In addition, the distribution of ISs associated with Tn1546-like elements among the Korean isolates is therefore similar to that among European vancomycin-resistant enterococci.

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“…Vancomycin-resistance rate of Enterococcus faecium has risen significantly, but this rate in Korea differ significantly from that of western countries because of the different types of selective pressure or patterns of nosocomial spread (2). Linezolid, the first available oxazolidinone for clinical use, has been shown to be effective in treating serious methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) infections (3).…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-ResistantEnterococcus faeciumMeningitis Treated with Linezolid: A Case Report and Review of the Literature

et al. 2010

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Vancomycin-resistant enterococci (VRE) infection is a serious problem because optimal therapy has not been established. Different agents in various combinations, including teicoplanin, chloramphenicol, and quinupristin/dalfopristin, have been used to treat patients with VRE meningitis, but the efficacy of these agents is not satisfactory because of their limited ability to penetrate into the cerebrospinal fluid.We report a case of nosocomial vancomycin-resistant Enterococcus faecium meningitis in a patient with ventriculoperitoneal shunt that was successfully treated with linezolid. We will also review previously reported cases of vancomycinresistant E. faecium meningitis treated by linezolid.

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Sudden increase of vancomycin-resistant enterococcal infections in a Korean tertiary care hospital: possible consequences of increased use of oral vancomycin

Cited by 39 publications

References 26 publications

Global Spread of Vancomycin-resistantEnterococcus faeciumfrom Distinct Nosocomial Genetic Complex

Global Spread of Vancomycin-resistantEnterococcus faeciumfrom Distinct Nosocomial Genetic Complex

Distribution of Insertion Sequences Associated with Tn 1546 -Like Elements among Enterococcus faecium Isolates from Patients in Korea

Vancomycin-ResistantEnterococcus faeciumMeningitis Treated with Linezolid: A Case Report and Review of the Literature

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