Sudden emergence and spread of cutaneous larva migrans in Sudan: A case series calls for urgent actions

Ahmed, Ayman; Hemaida, Maisa Aldai; Hagelnur, Amel Ahmed; Eltigani, Hala Fathi; Siddig, Emmanuel Edwar

doi:10.1016/j.idcr.2023.e01789

Cited by 8 publications

(5 citation statements)

References 19 publications

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“… 3 , 6 , 7 , 31 , 32 , 33 Recently, there is growing evidence about disease emergence and unusual presentation of endemic diseases. 24 , 33 , 34 , 35 Alternatively, this difference in the clinical manifestation of RVF infection could be attributed to variation in the virus strains of some clades of viruses are more associated with severe clinical presentations of the disease. 36 , 37 , 38 A similar situation has been observed during the currently ongoing Mpox outbreak of global concern.…”

Section: Discussionmentioning

confidence: 99%

“…10,[18][19][20][21] Studies have suggested that the major risk factors that drive this upsurge in the burden and outbreaks of infectious diseases and rapid spread of invasive diseases vectors include climate change, armed-conflicts and the growing size of population living in humanitarian crisis, globalization, and unplanned urbanization. 1,13,[22][23][24][25][26][27] These risk factors increase the dynamic and the interactions of different populations of human and animals substantially, this in turn magnifies the occurrence of spill over and pathogens sharing events across the different species of diseases-susceptible hosts. 28 Despite the frequent outbreaks of arboviral diseases in Sudan, still there is a huge gap in the local knowledge about the epidemiology, pathology, and the clinical presentation and outcome of patients, particularly in cases of co-infection.…”

Section: Introductionmentioning

confidence: 99%

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Rift Valley fever and malaria co‐infection: A case report

Ali,

Siddig,

Mohamed

et al. 2023

Clinical Case Reports

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Key Clinical MessageWe report a case of febrile illness that was presented with mild symptoms. However, laboratory investigation confirmed a malaria and Rift Valley fever co‐infection. Healthcare providers in settings endemic with several infectious diseases should seek rolling out possibilities of other infections prior to starting treatment for achieving effective case management with less resources and better safety of patients.AbstractHere we report a case of febrile illness that confirmed to be a co‐infection of malaria and Rift Valley fever. The patient was initially diagnosed with malaria and started on treatment immediately. However, due to the lack of response to the treatment further laboratory investigations were pursued.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rift Valley fever and malaria co‐infection: A case report

Ali,

Siddig,

Mohamed

et al. 2023

Clinical Case Reports

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“…Additional negative impacts of the spread of F. falciforme include threats to food security and a loss of biodiversity, as well as endangering forest and ecosystem stability. Therefore, successful prevention and control of F. falciforme require the implementation of a transdisciplinary One Health strategy including the integration of disease surveillance and response systems [59][60][61][62]. Furthermore, such a strategy needs to be supported by improved diagnosis, cross-country and multisectoral coordinated surveillance systems, comprehensive documentation, and immediate public sharing of data, particularly urgently needed information such as new emergences of novel pathogens and drug resistance [59].…”

Section: Discussionmentioning

confidence: 99%

The First Case of Fusarium falciforme Eumycetoma in Sudan and an Extensive Literature Review about Treatment Worldwide

Siddig

Ahmed

Eltigani

et al. 2023

JoF

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Eumycetoma is an infectious disease caused by various fungal pathogens. The disease is characterised by black and pale-yellowish grain discharge. In this communication, we report a case of eumycetoma with a pale grain foot-eumycetoma caused by Fusarium falciforme. The patient presented at the outpatient clinic of the Mycetoma Research Centre in Sudan. The causative agent was initially misidentified as Aspergillus nidulans based on its seemingly similar histopathological appearance. However, sequencing the internally transcribed spacer region of the extracted grain confirmed infection with Fusarium falciforme. Although the patient received Itraconazole and underwent surgical excision, the disease was recurrent. To our knowledge, this is the first report on Fusarium falciforme causing eumycetoma in Sudan, indicating the expansion of the geographical distribution of this pathogen. This calls for raising the awareness of healthcare providers and improving the diagnostic and surveillance systems in at-risk areas to improve the case management and reduce the threat of further spread. Considering the potential impacts of F. falciforme infection including threatening the global health, food security, and ecosystem balance, as well as loss of biodiversity and negative socioeconomic changes in endemic countries, we recommend the implementation of an integrated transdisciplinary One Health strategy for the prevention and control of emerging infectious diseases including F. falciforme.

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“… 14 , 15 , 16 , 17 , 18 , 19 This atypical presentation of infectious diseases including mycetoma highlights the need for improving the diagnostic capacity particularly in areas endemic with more than one of infectious diseases with overlapping symptoms. 6 , 20 , 21 This improvement needs to be at the education and continuous training of healthcare providers as well as the infrastructure and integrating the use of more robust diagnostic tools such as molecular and genomic sequencing in these endemic areas. 12 Healthcare providers in such settings should be highly skeptical and try to thoroughly examine their patients and carefully revising their travel and medical history.…”

Section: Discussionmentioning

confidence: 99%

Unusual manifestation of cystic mycetoma lesions: A case report

Abdallah,

Abdelkhalig,

Hamid

et al. 2023

Clinical Case Reports

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Key Clinical MessageThis case presents an atypical cystic presentation of mycetoma without sinuses or discharge. Awareness of these variations is crucial for accurate diagnosis and timely intervention, highlighting the need for healthcare professionals to consider diverse manifestations of mycetoma.AbstractMycetoma is a chronic and debilitating infectious disease characterized by localized swellings and granulomatous lesions. It primarily affects individuals in tropical and subtropical regions and is caused by certain fungi or bacteria. While mycetoma typically presents with sinuses and discharge, this case report presents a unique cystic presentation without these features. The patient, a 12‐year‐old female from Sudan, presented with a painless swelling on the dorsum of her right foot. Physical examination revealed a round, non‐tender, and fluctuant mass. Histopathological examination confirmed actinomycetoma caused by Streptomyces somaliensis. The patient was successfully treated with a combination of antibiotherapy. This atypical presentation underscores the need for healthcare professionals to consider uncommon variations of mycetoma for accurate diagnosis and management.

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Sudden emergence and spread of cutaneous larva migrans in Sudan: A case series calls for urgent actions

Cited by 8 publications

References 19 publications

Rift Valley fever and malaria co‐infection: A case report

Rift Valley fever and malaria co‐infection: A case report

The First Case of Fusarium falciforme Eumycetoma in Sudan and an Extensive Literature Review about Treatment Worldwide

Unusual manifestation of cystic mycetoma lesions: A case report

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