Sudden Death of an Infant with Rhinovirus Infection Complicating Bronchial Asthma: Case Report

Heras, Jorge Las; Swanson, Virginia L.

doi:10.3109/15513818309040669

Cited by 41 publications

(14 citation statements)

References 6 publications

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“…Despite these findings, some (4-6), but not all (7,8) epidemiologic studies have linked RVwith lower airway syndromes such as bronchitis, bronchiolitis, and pneumonia. There are also documented reports of fatal RV pneumonia in children, including a case in which RV was recovered from lung tissue at autopsy (9).…”

Section: Rhinovirus (Rv) Infection Is a Common Cause Of Both Upper Rementioning

confidence: 96%

Detection of rhinovirus RNA in lower airway cells during experimentally induced infection.

Gern¹,

Galagan²,

Jarjour³

et al. 1997

Am J Respir Crit Care Med

258

161

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Rhinovirus (RV) infections are presumed to be localized to the upper airway, yet can cause severe lower airway symptoms in children and adults with asthma. To test the hypothesis that rhinovirus infection of the upper airway may be associated with the presence of virus in lower airway cells, we used the techniques of reverse transcription-polymerase chain reaction (RT-PCR) and Southern blotting to detect RV RNA in lower airway cells from eight allergic volunteers experimentally infected with RV16. Bronchoscopy with bronchoalveolar lavage (BAL) was done 1 mo before, and 2 and 4 d after an experimental infection with RV16. All subjects developed cold symptoms, and infection was confirmed by culturing RV16 from nasal secretions. Rhinovirus RNA was detected in both nasal lavage and lower airway cells from all eight subjects 2 to 4 d after an experimental inoculation, but not in any of the precold specimens from either the nose or the lower airway. These findings suggest that RV can infect cells of the lower airway, and raise the possibility that such an effect can promote asthma exacerbations in the susceptible host through direct enhancement of local inflammation.

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Section: Rhinovirus (Rv) Infection Is a Common Cause Of Both Upper Rementioning

confidence: 96%

Detection of rhinovirus RNA in lower airway cells during experimentally induced infection.

Gern¹,

Galagan²,

Jarjour³

et al. 1997

Am J Respir Crit Care Med

258

161

View full text Add to dashboard Cite

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“…RV infection can induce lower respiratory tract symptoms, including cough, shortness of breath, chest tightness, and wheezing in patients with underlying asthma or other chronic lung diseases [13•, 34–38]. As IgE levels rise, the severity of lower respiratory tract symptoms increases in the asthmatic group [30].…”

Section: Rhinovirus-induced Respiratory Pathogenesismentioning

confidence: 99%

Immune Responses in Rhinovirus-Induced Asthma Exacerbations

Steinke

Borish

2016

Curr Allergy Asthma Rep

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Acute asthma exacerbations are responsible for urgent care visits and hospitalizations; they interfere with school and work productivity, thereby driving much of the morbidity and mortality associated with asthma. Approximately 80 to 85 % of asthma exacerbations in children, adolescents, and less frequently adults are associated with viral upper respiratory tract viral infections, and rhinovirus (RV) accounts for ~60–70 % of these virus-associated exacerbations. Evidence suggests that it is not the virus itself but the nature of the immune response to RV that drives this untoward response. In particular, evidence supports the concept that RV acts to exacerbate an ongoing allergic inflammatory response to environmental allergens present at the time of the infection. The interaction of the ongoing IgE- and T cell-mediated response to allergen superimposed on the innate and adaptive immune responses to the virus and how this leads to triggering of an asthma exacerbation is discussed.

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“…117 Increases in IgE levels could be viral or aller-matosis 124 and from the lungs of an 11 month old infant dying from asthma. 125 In addition, gen-specific or could simply represent a generalised upregulation of IgE production. In a viral cultures from sputum are more often positive for rhinovirus than from throat and nasal small study of 12 children with asthma attacks precipitated by influenza the levels of house swabs, suggesting that viral replication may …”

Section: Kininsmentioning

confidence: 99%