Sudden Death in Sickle Cell Anaemia: Report of Three Cases with Brief Review of Literature

Niraimathi, Manickam; Kar, Rakhee; Jacob, Sajini Elizabeth; Basu, Debdatta

doi:10.1007/s12288-015-0571-9

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…She developed sudden chest pain, breathlessness and died. She had previous history of jaundice during the ninth month of gestation and found to be sickle cell anemia on investigations [10].…”

Section: Discussionmentioning

confidence: 99%

Case Report on Sickle Cell Anaemia (SS Pattern)

Waghaye

Sakharkar

Gujar

et al. 2021

JPRI

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Sickle cell anemia is a kind of hemolytic anemia that is passed down in families. It is a kind of hemolytic anemia caused by inheriting the sickle hemoglobin gene. Africans, as well as individuals from the Middle East, the Mediterranean region, and India's aboriginal tribes, have a lower level of the sickle hemoglobin (HbS) gene. A kind of anemia that affects both children and adults is sickle cell anemia. Clinical Finding: Since 5 days, A 25-year-old man has been experiencing generalized bodily pain and anxiety. Examining the Problem: ALT (SGPT)- 97 U/L, AST (SGOT)- 56 U/L, total bilirubin – 5.4 mg percent, bilirubin conjugated – 1.7 mg percent, bilirubin unconjugated – 3.7 mg percent, total RBC count – 3.71 million/cu mm, total WBC count – 22100 cu mm, total platelets count – 6.46 lack/cu. Ultrasonography: Heterogeneous spleen. Therapeutic Intervention: Inj. Piptaz 4.5 gm TDS, inj. Levoflox 500 mg, tab. Hydroxyurea 500 mg, tab. Neurobion forte, inj. Pan 40 mg, inj. Tramadol 100 mg. Outcome: The client's condition has improved as a result of the treatment. He has no longer generalized bodily aches, and his anxiety levels have decreased. Conclusion: A 25-year-old man was admitted to Acharya Vinoba Bhave Hospital's Medicine ward with a history of sickle cell anaemia and complaints of nonspecific body aches and anxiousness. His condition improved after he received proper therapy.

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Section: Discussionmentioning

confidence: 99%

Case Report on Sickle Cell Anaemia (SS Pattern)

Waghaye

Sakharkar

Gujar

et al. 2021

JPRI

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“…Despite a tacit consensus on high under 5 mortality caused by SCD in LMICs, there is little empirical data published on the clinical or socio-demographic profile of mortality related to SCD in India and other LMICs. A discussion on mortality might appear as part of clinical profile, treatment outcomes, hospital morbidity surveys ( 21 , 22 ), case reports ( 23 ), perinatal outcomes ( 24 , 25 ), or newborn cohort follow-up studies ( 25 , 26 ). Insights into the importance of a social profiling of hospital deaths is exceptional ( 27 – 29 ).…”

Section: Introductionmentioning

confidence: 99%

A social profile of deaths related to sickle cell disease in India: a case for an ethical policy response

Chattoo,

Jain,

Nashine

et al. 2023

Front. Public Health

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India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year, second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment options, SCD remains a largely neglected disease within healthcare policy and practice. Epidemiological modeling based on small, often dated, regional studies (largely from sub-Saharan Africa) estimate that between 50 and 90 percent of affected children will/die before the age of 5 years. This premise, coupled with targets of reducing under 5 mortality (SDG 4), privileges public health interventions for screening and prevention of new births, undermining investments in long-term health and social care. This paper presents a retrospective, descriptive analysis of the socio-demographic profile of 447 patients diagnosed with sickle cell or sickle-beta thalassemia, who died following admission at a tertiary care entre in India. We used anonymized hospital records of 3,778 sickle cell patients, admitted in pediatric and adult/medical wards between January 2016 and February 2021. A majority of hospital deaths occurred in the second and third decades of life, following a hospital admission for a week. The overall mortality during 2016–2019 was 14% with little gender difference over time. Contrary to our expectations, the number of hospital deaths did not increase during the first year of the COVID-19 pandemic, between 2020 and 2021. The conclusion highlights the importance of longitudinal, socio-demo-graphic data on deaths as providing important insights for identifying ethical policy interventions focused on improving SCD outcomes over time, reducing inequities in access to care, and preventing what might be considered “excess” deaths.

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