Sudden death from occlusive disease of the atrioventricular node artery

Anderson, Kenneth; Bowie, J. T.; Dempster, A. G.; Gwynne, J. F.

doi:10.3109/00313028109059060

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…Coronary artery fibromuscular dysplasia is considered rare (1, 2). Fibromuscular dysplasia of the small cardiac conduction system arteries, such as AV and SA nodal arteries, is also considered rare, but has been described in a few cases (3, 4, 11, 12). Fibromuscular dysplasia of the coronary arteries is described rarely in infants/children (8, 9)…”

Section: Discussionmentioning

confidence: 99%

“…Fibromuscular dysplasia can also affect the small arteries of the cardiac conduction system such as the AV and SA nodal arteries (3, 4, 6, 7, 11, 12, 20). James et al describe a case report of the sudden death of a previously healthy 29 year old man who had greater than 95% occlusion of the artery supplying the His bundle by focal fibromuscular dysplasia (11).…”

Section: Discussionmentioning

confidence: 99%

“…Nichols et al describe a case of the sudden death of a previously healthy 28 year old female where the only pathologic finding was focal marked fibromuscular dysplasia of the SA nodal artery (3). Anderson et al describe two cases of sudden death in a 17 year old female and 40 year old man (4). The only significant pathological lesion found in both cases was fibromuscular dysplasia of the AV nodal artery (4).…”

Section: Discussionmentioning

confidence: 99%

“…Fibromuscular dysplasia is a non-atherosclerotic, non-inflammatory vascular disease that is most commonly found in the renal arteries of premenopausal women (1–2). However, this disease entity has rarely been described in the coronary arteries and small cardiac conduction arteries (1–4). To our knowledge, there is no recorded case of fibromuscular dysplasia in small cardiac conduction arteries in infants/children.…”

Section: Introductionmentioning

confidence: 99%

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Sudden Death in 14 Month Old Due to Fibromuscular Dysplasia of Atrioventricular Nodal Artery

Slemp

Hoover

Prahlow

2011

Academic Forensic Pathology

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Fibromuscular dysplasia is a non-atherosclerotic, non-inflammatory vascular disease that is most commonly found in the renal arteries of pre-menopausal women. However, this disease entity has rarely been described in the coronary arteries and small cardiac conduction arteries. To our knowledge, there is no recorded case of fibromuscular dysplasia in small cardiac conduction arteries in infants/children. In this report, we present a case of unexplained death of a 14 month old wherein routine histologic examination failed to reveal a cause of death, but subsequent submission of the cardiac conduction system (atrioventricular [AV] and sinoatrial [SA] node regions) demonstrated the presence of isolated AV nodal artery fibromuscular dysplasia, which was considered the cause of death. The case serves to emphasize the potential importance of evaluating the cardiac conduction system in cases where routine gross and microscopic autopsy fails to reveal an adequate explanation for death.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sudden Death in 14 Month Old Due to Fibromuscular Dysplasia of Atrioventricular Nodal Artery

Slemp

Hoover

Prahlow

2011

Academic Forensic Pathology

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“…None had fibrosis of the AVN or His bundle. The authors found 13 other cases of sudden death due to FMH of the AVN artery (17)(18)(19)(20)(21). One patient has a history of third degree AV block and syncope, six had fibrosis of the AVN, His bundle or both and one had an infarct of the His bundle.…”

Section: Fmh Of the Avn Arterymentioning

confidence: 99%

Histopathology of the Cardiac Conduction System in the Investigation of Sudden Unexpected Death

Cohle

2011

Academic Forensic Pathology

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When a gross and microscopic autopsy, drug screen, and past medical history fail to yield a cause of death, the forensic pathologist may opt to study the cardiac conduction system. This paper describes the excision of the SA (sinoatrial) node and AV(atrioventricular) node-containing areas of the heart and the microscopic appearance of normal SA and AV nodes, His bundle and bundle branches. Conduction system findings that have been reported to be significant include fibromuscular hyperplasia (often mislabeled dysplasia) of the SA and AV nodes arteries, persistent fetal dispersion of the AV node and His bundle, accessory pathways, ganglionitis and neuritis near the SA node, fibrosis and fatty infiltration of the conducting tissue, AV node tumor, left-sided His bundle, and AV node fibrosis. In an otherwise normal autopsy, AV node tumors, severe fibromuscular hyperplasia of the AV node artery and AV node fibrosis are sufficient to cause death. Other findings, particularly Mahaim tracks, are competent causes of death if they correlate with premortem electrocardiographic findings. Conduction system examination, although a low-yield procedure, is a worthwhile endeavor. Care must be taken to not overestimate the significance of the findings.

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Plötzlicher Tod bei sexueller Aktivität

Zack

Rummel

2008

Rechtsmedizin

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Sudden death from occlusive disease of the atrioventricular node artery

Cited by 14 publications

References 15 publications

Sudden Death in 14 Month Old Due to Fibromuscular Dysplasia of Atrioventricular Nodal Artery

Sudden Death in 14 Month Old Due to Fibromuscular Dysplasia of Atrioventricular Nodal Artery

Histopathology of the Cardiac Conduction System in the Investigation of Sudden Unexpected Death

Plötzlicher Tod bei sexueller Aktivität

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