Sudden Deafness and Lyme Disease

Lorenzi, Maria Cecília; Bittar, Roseli Saraiva Moreira; Pedalini, Maria Elisabete Bovino; Zerati, Fabio Elias; Yoshinari, Natalino Hajime; Bento, Ricardo Ferreira

doi:10.1097/00005537-200302000-00021

Cited by 42 publications

(39 citation statements)

References 7 publications

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“…A third of the patients with increased Borrelia titers were initially treated with antibiotics, but, in our analysis, hearing outcome was not related to the treatment given. This is in agreement with earlier studies with respect to ISSNHL [13], and similar to results from the use of antibiotics for treatment of patients with facial palsy and high Borrelia titers. If the infection is ongoing, it should always be treated with antibiotics since neuroborreliosis is a severe chronic disease-even if the antibiotics do not specifically cure the hearing loss.…”

Section: Laboratory Examinationssupporting

confidence: 93%

Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome

Nosrati-Zarenoe

Hansson

Hultcrantz

2010

Acta Oto-Laryngologica

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Methods:The first 400 patients submitted to the Swedish national database for SSNHL were analyzed. Information was collected at the first visit about the patient's past medical history, potential precipitating events traumata, family medical history, hearing loss, current disease, diagnostic protocol and treatment using questionnaires as well as two audiograms for each patient, one at the first visit to the ENT-clinic and one three months later.Results: 65% of these 400 patients underwent hematological tests and 40% had an MRI/CT.22/160 MRI investigated had pathological findings: five acoustic neuromas, one subdural hematoma, one pons infarction, five vascular abnormalities and ten patients had accidental findings not connected to the hearing tracts. 300 of these 400 patients were evaluated as idiopathic sudden sensorineural hearing loss (ISSNHL); 24% of them had one or more pathological tests. No significant correlation was found between either the MRI findings or the laboratory findings with regard to either treatment or hearing recovery in patients with ISSNHL. Conclusion:Results from a database for SSNHL demonstrate no correlation between laboratory findings, treatment and outcome in 400 patients. The patients with pathological tests were not treated differently from those with normal tests or no tests taken. The value of laboratory findings and MRI might increase if the results are categorized to more specific diagnoses.

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Section: Laboratory Examinationssupporting

confidence: 93%

Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome

Nosrati-Zarenoe

Hansson

Hultcrantz

2010

Acta Oto-Laryngologica

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“…Otolaryngological manifestations are common in Lyme disease, affecting up to 75% of the patients [3]. In our study, the hearing loss was more profound in the patients with ISD than in the patients with LD.…”

Section: Discussionsupporting

confidence: 42%

“…Literature suggests that sudden sensorineural hearing loss may coincide with Borrelia burgdorferi infection [2]. A higher incidence of confirmed positive serology for Borrelia burgdorferi in patients with sudden deafness seems to be depending on the country and on the tests used to confirm Lyme disease [3]. On the basis of clinical standpoints, clinical inner ear manifestations are common in both diseases [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Cochlear and Vestibular Functional Study in Patients with Sudden Deafness and Lyme Disease

Selmani¹,

Pyykkö²

2014

IJOHNS

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Lyme disease (LD) and idiopathic sudden deafness (ISD) are supposed to be different diseases with different aetiologies. In an attempt to confirm this assumption, 10 patients with confirmed LD and 12 patients with ISD were consecutively included into the study. Further to the laboratory and audio logical investigation, a low frequency sound (LFS) stimulation on posturography was performed and evaluated. Patients with ISD had higher pure tone average (PTA) than patients with LD (PTA ISD/LD was 72 decibel (dB)/23 dB). There was no difference of vertigo between LD and ISD patients. Patients with ISD have more body sway velocity during the first stimulation than patients with LD. We conclude that the cochlear organ is more affected in ISD patients than in patients with LD. However, the vestibular organ seems to be affected in both diseases. ISD and LD are two different disease entities with different aetiologies but with common otological clinical signs.

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“…In another study, Lorenzi et al (43) described the presence of antibodies to this spirochete in 23.3% of 47 consecutive patients with sudden deafness enrolled in the study, emphasizing the diagnosis of LDLS in Brazilian patients with otolaryngological manifestations. However, the hearing out- In LDLS, arthritis can appear weeks, months, or years after the initial tick bite, and can be accompanied or not by skin lesions or neurological manifestations.…”

Section: Clinical Picture Of Lyme Disease-like Syndromementioning

confidence: 94%

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Mantovani

Costa²,

Gauditano

et al. 2007

Braz J Med Biol Res

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An emerging clinical entity that reproduces clinical manifestations similar to those observed in Lyme disease (LD) has been recently under discussion in Brazil. Due to etiological and laboratory particularities it is named LD-like syndrome or LD imitator syndrome. The condition is considered to be a zoonosis transmitted by ticks of the genus Amblyomma, possibly caused by interaction of multiple fastidious microorganisms originating a protean clinical picture, including neurological, osteoarticular and erythema migrans-like lesions. When peripheral blood of patients with LD-like syndrome is viewed under a dark-field microscope, mobile uncultivable spirochete-like bacteria are observed. PCR carried out with specific or conservative primers to recognize Borrelia burgdorferi sensu stricto or the genus Borrelia has been negative in ticks and in biological samples. Two different procedures, respectively involving hematoxylin and eosin staining of cerebrospinal fluid and electron microscopy analysis of blood, have revealed spirochetes not belonging to the genera Borrelia, Leptospira or Treponema. Surprisingly, co-infection with microorganisms resembling Mycoplasma and Chlamydia was observed on one occasion by electron microscopy analysis. We discuss here the possible existence of a new tick-borne disease in Brazil imitating LD, except for a higher frequency of recurrence episodes observed along prolonged clinical follow-up.

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Sudden Deafness and Lyme Disease

Abstract: No distinctive clinical characteristic was found between seropositive and seronegative subjects. The hearing outcome of treated Borrelia-seropositive patients was similar to that of the seronegative group.

Cited by 42 publications

References 7 publications

Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome

Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome

Cochlear and Vestibular Functional Study in Patients with Sudden Deafness and Lyme Disease

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

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